ProRule PRU00895

General rule information [?]

Accession	PRU00895
Dates	15-MAR-2012 (Created) 11-JAN-2024 (Last updated, Version 28)
Data class	Domain;
Predictors	PROSITE; PS51562; RNA_CAP0_MT
Name	mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56)
Function	mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to G(5')pppR-RNA to form m(7)G(5')pppR-RNA and S-adenosyl-L-homocysteine.
Scope(s)	Eukaryota Viruses
Example(s)	Q8SR66 (MCES_ENCCU); P04298 (MCEL_VACCW);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name

+ RecName: EC=2.1.1.56;

Comments [?]

CATALYTIC ACTIVITY	Reaction=a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S- adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA- COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, ChEBI:CHEBI:167617; EC=2.1.1.56;
case <OC:Eukaryota>
SIMILARITY	Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
else case <OC:Viruses>
SIMILARITY	In the C-terminal section; belongs to the class I-like SAM- binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
end case

Keywords [?]

Gene Ontology [?]

GO:0003723; Molecular function:RNA binding

GO:0004482; Molecular function:mRNA 5'-cap (guanine-N7-)-methyltransferase activity

GO:0006370; Biological process:7-methylguanosine mRNA capping

GO:0032259; Biological process:methylation

GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51562

Key

From

Description

Tag

Condition

FTGroup

DOMAIN

from

/note="mRNA cap 0 methyltransferase #"

BINDING

/ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"

x-N

case <OC:Eukaryota>

BINDING