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PROSITE documentation PDOC00054

Ribosomal protein S12 signature

Description:

Ribosomal protein S12 is one of the proteins from the small ribosomal subunit. In Escherichia coli, S12 is known to be involved in the translation initiation step. It is a very basic protein of 120 to 150 amino-acid residues. S12 belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1], groups:

  • Eubacterial S12.
  • Archaebacterial S12.
  • Algal and plant chloroplast S12.
  • Cyanelle S12.
  • Protozoa and plant mitochondrial S12.
  • Yeast S28.
  • Drosophila mitochondrial protein tko (Technical KnockOut).
  • Mammalian S23.

As a signature pattern, we selected the best conserved regions in these proteins, located in the center of each sequence.

Last update:

November 1995 / Text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_S12, PS00055; Ribosomal protein S12 signature  (PATTERN)
Consensus pattern: [RK]-x-P-N-S-[AR]-x-R
Sequences known to belong to this class detected by the pattern: ALL, except for some mitochondrial S12 and Micrococcus luteus S12
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00055
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00055
• Scan Swiss-Prot/TrEMBL entries against PS00055
• view ligand binding statistics
Matching PDB structures: 1FJG 1GIX 1HNW 1HNX ... [ALL]

Reference:

1 AuthorsOtaka E., Hashimoto T., Mizuta K.
SourceProtein Seq. Data Anal. 5:285-300(1993).

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