|PROSITE documentation PDOC00096
Purine/pyrimidine phosphoribosyl transferases signature
Phosphoribosyltransferases (PRT) are enzymes that catalyze the synthesis of
β-n-5'-monophosphates from phosphoribosylpyrophosphate (PRPP) and an enzyme
specific amine. A number of PRT's are involved in the biosynthesis of purine,
pyrimidine, and pyridine nucleotides, or in the salvage of purines and
pyrimidines. These enzymes are:
- Adenine phosphoribosyltransferase (EC 184.108.40.206) (APRT), which is involved in
- Hypoxanthine-guanine or hypoxanthine phosphoribosyltransferase (EC 220.127.116.11)
(HGPRT or HPRT), which are involved in purine salvage.
- Orotate phosphoribosyltransferase (EC 18.104.22.168) (OPRT), which is involved
in pyrimidine biosynthesis.
- Amido phosphoribosyltransferase (EC 22.214.171.124), which is involved in purine
- Xanthine-guanine phosphoribosyltransferase (EC 126.96.36.199) (XGPRT), which is
involved in purine salvage.
In the sequence of all these enzymes there is a small conserved region which
may be involved in the enzymatic activity and/or be part of the PRPP binding
In position 11 of the pattern most of these enzymes have Gly.
November 1997 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|PUR_PYR_PR_TRANSFER, PS00103; Purine/pyrimidine phosphoribosyl transferases signature (PATTERN)
|Sequences known to belong to this class detected by the pattern:
||ALL, except for Bacillus subtilis xanthine phosphoribosyltransferase
|Other sequence(s) detected in Swiss-Prot:
||bacterial phosphoribosyl pyro- phosphate synthases and 7 other proteins.
|Matching PDB structures:
1A95 1A96 1A97 1AO0 ... [ALL]
||Hershey H.V., Taylor M.W.
||Nucleotide sequence and deduced amino acid sequence of Escherichia coli adenine phosphoribosyltransferase and comparison with other analogous enzymes.
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