PROSITE documentation PDOC00096

Purine/pyrimidine phosphoribosyl transferases signature




Description

Phosphoribosyltransferases (PRT) are enzymes that catalyze the synthesis of β-n-5'-monophosphates from phosphoribosylpyrophosphate (PRPP) and an enzyme specific amine. A number of PRT's are involved in the biosynthesis of purine, pyrimidine, and pyridine nucleotides, or in the salvage of purines and pyrimidines. These enzymes are:

  • Adenine phosphoribosyltransferase (EC 2.4.2.7) (APRT), which is involved in purine salvage.
  • Hypoxanthine-guanine or hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) (HGPRT or HPRT), which are involved in purine salvage.
  • Orotate phosphoribosyltransferase (EC 2.4.2.10) (OPRT), which is involved in pyrimidine biosynthesis.
  • Amido phosphoribosyltransferase (EC 2.4.2.14), which is involved in purine biosynthesis.
  • Xanthine-guanine phosphoribosyltransferase (EC 2.4.2.22) (XGPRT), which is involved in purine salvage.

In the sequence of all these enzymes there is a small conserved region which may be involved in the enzymatic activity and/or be part of the PRPP binding site [1].

Note:

In position 11 of the pattern most of these enzymes have Gly.

Last update:

November 1997 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

PUR_PYR_PR_TRANSFER, PS00103; Purine/pyrimidine phosphoribosyl transferases signature  (PATTERN)


Reference

1AuthorsHershey H.V., Taylor M.W.
TitleNucleotide sequence and deduced amino acid sequence of Escherichia coli adenine phosphoribosyltransferase and comparison with other analogous enzymes.
SourceGene 43:287-293(1986).
PubMed ID3527873



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