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| PROSITE documentation PDOC00500 |
Ribosomal protein S6e signature
Description:
A number of eukaryotic and archaebacterial ribosomal proteins can be grouped
on the basis of sequence similarities. One of these families consists of:
- Mammalian S6 [1].
- Drosophila S6 [2].
- Plant S6 [3].
- Yeast S10 (YS4).
- Halobacterium marismortui HS13 [4].
- Methanococcus jannaschii MJ1260.
S6 is the major substrate of protein kinases in eukaryotic ribosomes [5]; it
may have an important role in controlling cell growth and proliferation
through the selective translation of particular classes of mRNA.
These proteins have 135 to 249 amino acids. As a signature pattern, we
selected a conserved stretch of 12 residues in the N-terminal part of these
proteins.
Expert(s) to contact by email:
Thomas G.
Last update:
December 2004 / Pattern and text revised.
Technical section:
PROSITE method (with tools and information) covered by this documentation:
| RIBOSOMAL_S6E, PS00578; Ribosomal protein S6e signature (PATTERN) |
| Consensus pattern: |
[LIVM]-[STAMR]-G-G-x-[DG]-x(2)-G-x-[PV]-M
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| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE. |
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References:
| 1 |
Authors | Franco R., Rosenfeld M.G. |
| Title | Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6. |
| Source | J. Biol. Chem. 265:4321-4325(1990). |
| PubMed ID | 2106518 |
| 2 |
Authors | Watson K.L., Konrad K.D., Woods D.F., Bryant P.J. |
| Title | Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. |
| Source | Proc. Natl. Acad. Sci. U.S.A. 89:11302-11306(1992). |
| PubMed ID | 1454811 |
| 3 |
Authors | Hansen G., Estruch J.J., Spena A. |
| Title | Tobacco cDNA encoding the ribosomal protein S6. |
| Source | Nucleic Acids Res. 20:5230-5230(1992). |
| PubMed ID | 1408841 |
| 4 |
Authors | Kimura M., Arndt E., Hatakeyama T., Hatakeyama T., Kimura J. |
| Title | Ribosomal proteins in halobacteria. |
| Source | Can. J. Microbiol. 35:195-199(1989). |
| PubMed ID | 2655851 |
| 5 |
Authors | Bandi H.R., Ferrari S., Krieg J., Meyer H.E., Thomas G. |
| Title | Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum. |
| Source | J. Biol. Chem. 268:4530-4533(1993). |
| PubMed ID | 8440735 |
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