To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
PROSITE documentation PDOC00552

Gram-negative pili assembly chaperone signature





Description

Most Gram-negative bacteria possess a supramolecular structure - the pili - on their surface, that mediates attachment to specific receptors. The assembly of the pili requires the help of specialized periplasmic chaperones [1,2,3]. These proteins are structurally and possibly evolutionary related to the immunoglobulin family. Known members of this family are listed below:

  • Escherichia coli papD for P pili.
  • Escherichia coli afaB for AFA-III adhesin.
  • Escherichia coli aggD for AAF/I fimbriae.
  • Escherichia coli cssC for CS6 antigen.
  • Escherichia coli F17-D for F17 pili.
  • Escherichia coli faeE for K88 pili.
  • Escherichia coli fanE for K99 pili.
  • Escherichia coli fimC for type 1 fimbriae.
  • Escherichia coli focC for F1C fimbriae.
  • Escherichia coli nfaE for NFA-I adhesin.
  • Escherichia coli sfaE for S pili.
  • Escherichia coli clpE for CS31A capsule-like antigen.
  • Escherichia coli ecpD for a yet unknown pilin.
  • Escherichia coli CS3-1 for CS3 pili.
  • Bordetella pertussis fhaD (or fimB) for filamentous hemagglutinin and fimbria.
  • Haemophilus influenzae hifB for type b pili.
  • Klebsiella pneumoniae mrkB for type 3 pili.
  • Proteus mirabilis pmfD for PMF fimbriae.
  • Salmonella enteritidis sefB for sef14 fimbriae.
  • Salmonella typhimurium lpfB for long polar fimbriae.
  • Yersinia enterocolitica myfB for myf fimbriae.
  • Yersinia pestis caf1M for F1 capsule antigen.
  • Yersinia pestis psaB for pH6 antigen.
  • Escherichia coli hypothetical protein ybgP.
  • Escherichia coli hypothetical protein ycbF.
  • Escherichia coli hypothetical protein yehC.
  • Escherichia coli hypothetical protein yfcS.
  • Escherichia coli hypothetical protein yhcA.
  • Escherichia coli hypothetical protein yqiH.
  • Escherichia coli hypothetical protein yraI.

Structurally, these proteins consist of two globular domains with a topology identical to an immunoglobulin fold. As a signature pattern, we selected a highly conserved region located in the C-terminal section of the first globular domain.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

PILI_CHAPERONE, PS00635; Gram-negative pili assembly chaperone signature  (PATTERN)


References

1AuthorsHung D.L., Knight S.D., Woods R.M., Pinkner J.S., Hultgren S.J.
TitleMolecular basis of two subfamilies of immunoglobulin-like chaperones.
SourceEMBO J. 15:3792-3805(1996).
PubMed ID8670884

2AuthorsJacob-Dubuisson F., Kuehn M.J., Hultgren S.J.
SourceTrends Microbiol. 1:50-55(1993).

3Authorsvan Rosmalen M., Saier M.H. Jr.
SourceRes. Microbiol. 144:507-527(1993).



PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to
Prosite License or see: prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)