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PROSITE documentation PDOC00558

Bacterial ribonuclease P protein component signature


Ribonuclease P (EC (RNase P) [1,2,3] is a site specific endonuclease that generates mature tRNAs by cleaving-off the leader sequences at their 5'ends. In bacteria RNase P is known to be composed of two components: a large (about 400 base pairs) RNA (gene rnpB) and a small protein (119 to 133 amino acids) (gene rnpA). The RNA moiety of RNase P carries the catalytic activity; the function of the protein component is not yet clear although it may act as an electrostatic screen allowing the highly negatively charged RNA enzyme-substrate complex to fold into the catalytic conformation.

The sequence of rnpA is not highly conserved, however there is, in the central part of the protein, a conserved basic region. We have used this region as a signature pattern.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBONUCLEASE_P, PS00648; Bacterial ribonuclease P protein component signature  (PATTERN)


1AuthorsPace N.R., Smith D.
TitleRibonuclease P: function and variation.
SourceJ. Biol. Chem. 265:3587-3590(1990).
PubMed ID1689306

2AuthorsAltman S.
TitleRibonuclease P. Postscript.
SourceJ. Biol. Chem. 265:20053-20056(1990).
PubMed ID1700778

3AuthorsBrown J.W., Pace N.R.
TitleRibonuclease P RNA and protein subunits from bacteria.
SourceNucleic Acids Res. 20:1451-1456(1992).
PubMed ID1374553

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