It has been shown [1,2] that a number of cell-wall lytic enzymes (EC 188.8.131.52)
are evolutionary related and can be classified into a single family:
Lysozymes (lysin) from Streptococcus pneumoniae bacteriophages of the Cp
Lysozyme (endolysin) from Lactococcus delbrueckii phage mv1.
Autolytic lysozyme from Clostridium acetobutylicum.
Lysozyme M1 from Streptomyces globisporus.
N,O-diacetylmuramidase (lysozyme ch) from the fungus Chalaropsis.
Two residues, an aspartate and a glutamate, have been shown  to be
important for the catalytic activity of the Charalopsis enzyme. These residues
as well as some others in their vicinity are conserved in all proteins from
this family and can be used as a signature pattern.
PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
or see: prosite_license.html.