PROSITE documentation PDOC00740

NAD-dependent glycerol-3-phosphate dehydrogenase signature




Description

NAD-dependent glycerol-3-phosphate dehydrogenase (EC 1.1.1.8) (GPD) catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate. It is a eukaryotic cytosolic homodimeric protein of about 40 Kd. As a signature pattern we selected a glycine-rich region that is probably [1] involved in NAD-binding.

Last update:

April 2006 / Pattern revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

NAD_G3PDH, PS00957; NAD-dependent glycerol-3-phosphate dehydrogenase signature  (PATTERN)


Reference

1AuthorsOtto J., Argos P., Rossmann M.G.
TitlePrediction of secondary structural elements in glycerol-3-phosphate dehydrogenase by comparison with other dehydrogenases.
SourceEur. J. Biochem. 109:325-330(1980).
PubMed ID6773774



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