PROSITE documentation PDOC00740

NAD-dependent glycerol-3-phosphate dehydrogenase signature

Description

NAD-dependent glycerol-3-phosphate dehydrogenase (EC 1.1.1.8) (GPD) catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate. It is a eukaryotic cytosolic homodimeric protein of about 40 Kd. As a signature pattern we selected a glycine-rich region that is probably [1] involved in NAD-binding.

Last update:

April 2006 / Pattern revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

NAD_G3PDH, PS00957; NAD-dependent glycerol-3-phosphate dehydrogenase signature  (PATTERN)
Consensus pattern: [GSA]-[ATIVS]-[LIVMYCAFST]-K-[DN]-[LIVMA]-[LIVMFYT]-[GA]-x-[GACKMSIFT]-x-G-[ALIVMF]-x(2)-[SGAQ]-[LIVMYERAKQFS]-x(0,1)-[TLIVMFYWAQ]-[ETGAS]-x(0,1)-[NDVS]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00957
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00957
• Scan Swiss-Prot/TrEMBL entries against PS00957
• view ligand binding statistics
Matching PDB structures: 1EVY 1EVZ 1JDJ 1M66 ... [ALL]

Reference

1 Authors Otto J., Argos P., Rossmann M.G.
Title Prediction of secondary structural elements in glycerol-3-phosphate dehydrogenase by comparison with other dehydrogenases.
Source Eur. J. Biochem. 109:325-330(1980).
PubMed ID 6773774

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