PROSITE documentation PDOC00787Glycosyl hydrolases family 39 putative active site
Description
It has been shown [1,E1] that the following glycosyl hydrolases can be classified into a single family on the basis of sequence similarities:
- Mammalian lysosomal α-L-iduronidase (EC 3.2.1.76).
- Caldocellum saccharolyticum and Thermoanaerobacter saccharolyticum β- xylosidase (EC 3.2.1.37) (gene xynB).
The best conserved regions in these enzymes is located in the N-terminal section. It contains a glutamic acid residue which, on the basis of similarities with other families of glycosyl hydrolases [2], probably acts as the proton donor in the catalytic mechanism. We use this region as a signature pattern.
Expert(s) to contact by email: Last update:May 2004 / Text revised.
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References
| 1 | Authors | Henrissat B. Bairoch A. |
| Title | New families in the classification of glycosyl hydrolases based on amino acid sequence similarities. | |
| Source | Biochem. J. 293:781-788(1993). | |
| PubMed ID | 8352747 |
| 2 | Authors | Henrissat B. Callebaut I. Fabrega S. Lehn P. Mornon J.-P. Davies G. |
| Title | Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 92:7090-7094(1995). | |
| PubMed ID | 7624375 |
| E1 | Title | https://www.uniprot.org/docs/glycosid |
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