To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
PROSITE documentation PDOC00787

Glycosyl hydrolases family 39 putative active site





Description

It has been shown [1,E1] that the following glycosyl hydrolases can be classified into a single family on the basis of sequence similarities:

  • Mammalian lysosomal α-L-iduronidase (EC 3.2.1.76).
  • Caldocellum saccharolyticum and Thermoanaerobacter saccharolyticum β- xylosidase (EC 3.2.1.37) (gene xynB).

The best conserved regions in these enzymes is located in the N-terminal section. It contains a glutamic acid residue which, on the basis of similarities with other families of glycosyl hydrolases [2], probably acts as the proton donor in the catalytic mechanism. We use this region as a signature pattern.

Expert(s) to contact by email:

Henrissat B.

Last update:

May 2004 / Text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

GLYCOSYL_HYDROL_F39, PS01027; Glycosyl hydrolases family 39 active site  (PATTERN)


References

1AuthorsHenrissat B., Bairoch A.
TitleNew families in the classification of glycosyl hydrolases based on amino acid sequence similarities.
SourceBiochem. J. 293:781-788(1993).
PubMed ID8352747

2AuthorsHenrissat B., Callebaut I., Fabrega S., Lehn P., Mornon J.-P., Davies G.
TitleConserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.
SourceProc. Natl. Acad. Sci. U.S.A. 92:7090-7094(1995).
PubMed ID7624375

E1Sourcehttp://www.uniprot.org/docs/glycosid



PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to
Prosite License or see: prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)