To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS. To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017. From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...] View this page in https
Chitinases (EC 184.108.40.206)  are enzymes that catalyze the hydrolysis of the
β-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. From the view
point of sequence similarity chitinases belong to either family 18 or 19 in
the classification of glycosyl hydrolases [2,E1]. Chitinases of family 18
(also known as classes III or V) groups a variety of proteins:
a) Chitinases from:
- Prokaryotes such as Alteromonas, Bacillus, Serratia, Streptomyces, etc.
- Plants such as Arabidopsis, cucumber, bean, tobacco, etc.
- Fungi such as Aphanocladium, Rhizopus, Saccharomyces, etc.
- Nematode (Brugia malayi).
- Insects (Manduca sexta).
- Baculoviruses (Autographa Californica Nuclear Polyhedrosis virus).
b) Other proteins:
- Hevamine, a rubber tree protein with chitinase and lysozyme activities.
- Kluyveromyces lactis killer toxin alpha subunit, which acts as a chitinase.
- Flavobacterium and Streptomyces endo-beta-N-acetylglucosaminidases (EC 3.2.
- Mammalian di-N-acetylchitobiase which is involved in the degradation of
- Human cartilage glycoprotein Gp-39.
- Jack bean concanavalin B (conB), a protein that has lost its catalytic
Site directed mutagenesis experiments  and crystallographic data [4,5] have
shown that a conserved glutamate is involved in the catalytic mechanism and
probably acts as a proton donor. This glutamate is at the extremity of the
best conserved region in these proteins.
PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
or see: prosite_license.html.