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PROSITE documentation PDOC00993

NAD:arginine ADP-ribosyltransferase signature

Description:

Mono(ADP-ribosyl)transferase (EC 2.4.2.31) catalyzes the transfer of the ADP-ribose moiety of nicotinamide adenine dinucleotide (NAD) to an acceptor amino acid in proteins. In vertebrates there is a family of such enzymes that transfer an NAD group to arginine [1].

At least five distinct forms of this enzyme has been found so far, some are attached to the membrane by a GPI anchor while others seem to be secreted. They are proteins of about 250 to 300 amino acid residues. As a signature pattern, we selected a conserved region in the central section of these enzymes.

Last update:

December 2004 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

ART, PS01291; NAD:arginine ADP-ribosyltransferases signature  (PATTERN)
Consensus pattern: [FY]-x-[FY]-K-x(2)-H-[FY]-x-L-[STI]-x-A
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01291
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01291
• Scan Swiss-Prot/TrEMBL entries against PS01291
• view ligand binding statistics
Matching PDB structures: 1GXY 1GXZ 1GY0 1OG1 ... [ALL]

Reference:

1 AuthorsOkazaki I.J., Kim H.-J., Moss J.
TitleCloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase.
SourceJ. Biol. Chem. 271:22052-22057(1996).
PubMed ID8703012

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