|PROSITE documentation PDOC50145
Zinc finger TRAF-type profile
TRAF proteins were isolated first by their ability to interact with TNF
receptor . They are involved in different cytoplasmic signal transduction
pathways. TRAF proteins are composed of 3 structural domains: a RING finger
(see <PDOC00449>) in the N terminal part of the protein, TRAF zinc fingers in
the middle part and the TRAF domain in the C terminal part. TRAF zinc fingers
contain 8 possible ligands for one or two zinc atoms. This domain is found
only in TRAF and TRAF-related proteins and its function is not yet known.
The profile we developed covers the whole domain.
January 2002 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|ZF_TRAF, PS50145; Zinc finger TRAF-type profile (MATRIX)
|Sequences in UniProtKB/Swiss-Prot known to belong to this class detected by PS50145:
||59 true positives with 8 false negatives.
|Other sequence(s) in UniProtKB/Swiss-Prot detected by PS50145:
|Matching PDB structures:
2EOD 2YRE 2YUC 3HCS [ALL]
||Rothe M., Wong S.C., Henzel W.J., Goeddel D.V.
||A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
View entry in original PROSITE document format
View entry in raw text format (no links)