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PROSITE documentation PDOC50145

Zinc finger TRAF-type profile




Description

TRAF proteins were isolated first by their ability to interact with TNF receptor [1]. They are involved in different cytoplasmic signal transduction pathways. TRAF proteins are composed of 3 structural domains: a RING finger (see <PDOC00449>) in the N terminal part of the protein, TRAF zinc fingers in the middle part and the TRAF domain in the C terminal part. TRAF zinc fingers contain 8 possible ligands for one or two zinc atoms. This domain is found only in TRAF and TRAF-related proteins and its function is not yet known.

The profile we developed covers the whole domain.

Last update:

January 2002 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

ZF_TRAF, PS50145; Zinc finger TRAF-type profile  (MATRIX)


Reference

1AuthorsRothe M., Wong S.C., Henzel W.J., Goeddel D.V.
TitleA novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
SourceCell 78:681-692(1994).
PubMed ID8069916



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