|PROSITE documentation PDOC50145
Zinc finger TRAF-type profile
TRAF proteins were isolated first by their ability to interact with TNF
receptor . They are involved in different cytoplasmic signal transduction
pathways. TRAF proteins are composed of 3 structural domains: a RING finger
(see <PDOC00449>) in the N terminal part of the protein, TRAF zinc fingers in
the middle part and the TRAF domain in the C terminal part. TRAF zinc fingers
contain 8 possible ligands for one or two zinc atoms. This domain is found
only in TRAF and TRAF-related proteins and its function is not yet known.
The profile we developed covers the whole domain.
January 2002 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|ZF_TRAF, PS50145; Zinc finger TRAF-type profile (MATRIX)
|Sequences known to belong to this class detected by the profile:
|Other sequence(s) detected in Swiss-Prot:
|Matching PDB structures:
2EOD 2YRE 2YUC 3HCS [ALL]
||Rothe M., Wong S.C., Henzel W.J., Goeddel D.V.
||A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
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