To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS50145

General information about the entry

Entry name [info] ZF_TRAF
Accession [info] PS50145
Entry type [info] MATRIX
Date [info] 01-JAN-2002 CREATED; 10-MAY-2017 DATA UPDATE; 22-NOV-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC50145
Associated ProRule [info] PRU00207

Name and characterization of the entry

Description [info] Zinc finger TRAF-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=58;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=53;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.2380000; R2=0.0103698; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4021.1279297; R2=4.4351535; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=797; H_SCORE=7556; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=604; H_SCORE=6700; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=0; E1=0; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='S'; M=  6, -9,-15,-11,-11,-17, -2,-18,-10, -6,-16,-10, -5,-16,-11,-10, 12,  8,  2,-29,-17,-11;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='Y'; M=-13,-10,-27, -7, 10, -7,-25,  9, -8, -7,  4,  0,-12,-18,  8, -6,-13,-11,-15,-13, 11,  7;
/M: SY='K'; M=-11,  9,-29, 10, 10,-21, -4, -1,-27, 11,-24,-16,  8,-14,  2,  2, -4,-10,-24,-19, -4,  5;
/I:         I=-8; MI=0; MD=-15; IM=0; DM=-15;
/M: SY='T'; M= -7,  1,-19,  3,  0,-19,-21,-11, -6, -6, -9, -3, -5,-15,  0, -9,  1,  8,  1,-30,-12,  0;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P'; M= -8,-14,-35, -7,  1,-29,-17, -8,-21, -9,-29,-17,-12, 61, -2,-15, -3, -7,-27,-31,-24, -4;
/M: SY='R'; M=-14,-15, -8,-20,-10,  6,-24,-10,-14,  2, -9,  1,-10,-22, -3,  7,-13,-10,-11,-15,  0, -6;
/M: SY='F'; M= -9, -9,-21,-10,  2,  4,-23,-13, -1,-12,  2, -3, -7,-20,-12,-11, -9, -6,  1,-23, -6, -4;
/M: SY='P'; M= -4,-15,-26, -9,  1,-21,-20,-18, -9,-10,-18,-12,-15, 31, -9,-16, -1, -3, -6,-31,-22, -6;
/M: SY='V'; M= -5,-30,-17,-32,-27,  3,-32,-27, 31,-25, 25, 15,-28,-28,-25,-22,-18, -5, 33,-25, -5,-27;
/M: SY='P'; M= -4, -6,-25, -3, -4,-13,-16,-13,-17,-10,-20,-16, -7, 22,-10,-15,  3,  5,-16,-24,-10, -9;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P'; M= -9, -2,-29,  7,  9,-25,-17,-13,-19, -7,-20,-17, -8, 29, -5,-14, -2, -6,-19,-32,-22,  0;
/I:         I=-6; MI=-29; MD=-20; IM=-29;
/M: SY='N'; M=-11, 16,-20,  7,  2,-19, -8, 18,-19,  4,-21,-10, 27,-15, 10, 11,  2, -5,-23,-26, -9,  5; D=-6;
/I:         I=-8; MI=0; IM=0; DM=-20;
/M: SY='K'; M=-10,  3,-30,  6,  3,-32,  8, -7,-33, 13,-27,-14,  3,-14,  7, 12, -4,-13,-26,-23,-17,  4;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G'; M=  0, -7,-26, -6, -8,-28, 28,-16,-31, -6,-30,-19,  0, -1, -9,-10,  7, -7,-24,-26,-25, -9;
/M: SY='V'; M=  7,-14,-17,-15, -5,-14,-20,-18,  1,  0, -5,  1,-15,-17, -9, -7, -5, -4, 12,-25,-13, -7;
/I:         I=-8; MI=-5; MD=-15; IM=-5; DM=-15;
/M: SY='K'; M= -9, -1,-25, -4,  3,-23,-20,-11,-25, 31,-23,-10,  0,-11,  5, 25, -2,  6,-15,-23,-10,  3;
/M: SY='I'; M= -7,-29,-20,-33,-26,  3,-31,-23, 32,-24, 25, 23,-26,-26,-20,-21,-20, -7, 28,-23, -3,-24;
/M: SY='M'; M=  2,-15,-22,-15, -3,-12,-17,-13, -3,-13,  3,  4,-15,  2, -6,-15, -6, -4, -6,-26,-13, -5;
/M: SY='R'; M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='E'; M= -9,  0,-28,  4, 21,-27,-11, -5,-30, 20,-25,-15,  1,-10, 10, 20,  0, -7,-23,-26,-16, 14;
/M: SY='D'; M=-11, 18,-24, 27, 13,-25,-15, -7,-24, -1,-15,-17,  5,-12,  0, -7,  1, -1,-18,-33,-15,  6;
/M: SY='L'; M=-12,-30,-21,-33,-23, 21,-31,-21, 20,-30, 39, 16,-27,-29,-24,-21,-27,-10, 11,-15,  5,-23;
/M: SY='P'; M=  0,-12,-27,-12, -2,-24,-17,-12,-12, -3,-18, -9, -8, 16,  5, -1,  0, -5,-14,-25,-17, -1;
/M: SY='D'; M=  2, 19,-23, 24,  7,-32, -3, -7,-27, -3,-22,-18,  6,-11,  4,-10,  4, -4,-20,-30,-19,  6;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='L'; M=  2,-27,-16,-30,-23,  1,-27,-24, 22,-24, 24, 12,-26,-26,-22,-21,-16, -5, 24,-23, -6,-23;
/M: SY='E'; M= -7,  2,-25,  3, 20,-26,-18, -5,-24, 16,-22,-13,  1, -8, 15, 12,  5,  3,-20,-27,-14, 17;
/I:         I=-6; MI=-32; MD=-32; IM=-32;
/M: SY='D'; M= -7, 12,-17, 13,  4,-18, -7, 12,-20,  4,-20,-11, 13,-10,  3,  1,  4, -3,-16,-24, -7,  3; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='D'; M=  5, 13,-21, 18, 18,-27,-10, -8,-25, -2,-21,-19,  4, -7,  2,-10, 10,  2,-17,-32,-19, 10;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P'; M= -7,-10,-10,-10, -8,-23,-11,-16,-19, -2,-23,-14, -6, 10,-10, -5, -3, -6,-14,-31,-22,-10;
/M: SY='K'; M=-10,  7,-25,  0,  0,-16,-17, -2,-20, 20,-23,-11, 12,-15,  2, 11, -2,  1,-18,-19,  1,  0;
/M: SY='R'; M=  3,-11,  5,-16, -9,-19,-16,-13,-22,  4,-16,-12, -6,-20, -5, 18, -1,  0,-10,-27,-16, -9;
/M: SY='R'; M=-12, -9,-27, -8,  6,-14,-21, -7,-19,  5,-12, -8, -6, -2,  6, 16, -5, -1,-17,-22,-10,  4;
/M: SY='V'; M=  4,-19,-17,-22,-15,-10,-22,-19, 12,-15,  4,  4,-16,-20, -7,-15, -3, -2, 16,-26,-10,-12;
/M: SY='P'; M= -7,-14,-26,-13, -6,-15,-22,-19, -9, -7, -6, -7,-14, 21,-10,-11, -7,  6,-11,-26,-15,-10;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='S'; M= -1, -4,-23, -3,  8,-23,-13,-10,-23,  7,-24,-16, -1,  4,  3,  8,  9,  3,-17,-29,-18,  4;
/M: SY='F'; M=-20,-23,-24,-29,-23, 52,-29,  8, -4,-22,  3,  0,-16,-29,-25,-14,-19,-11, -7, 10, 42,-23;
/I:         I=-5; MI=-25; MD=-25; IM=-25;
/M: SY='H'; M= -9, -4,-16, -5, -1, -2,-13, 13,-14,  8,-11, -3, -1,-10,  0,  6, -7, -7,-11,-10,  4, -1; D=-5;
/I:         I=-5; MI=-25; MD=-25; IM=-25; DM=-25;
/M: SY='E'; M= -1,  4,-14,  5, 11,-14, -9, -4,-14,  4,-10, -9,  1, -5,  3,  5,  1,  0,-11,-16, -9,  7; D=-5;
/I:         I=-5; MI=-25; MD=-25; IM=-25; DM=-25;
/M: SY='Y'; M= -3, -8,-12, -9, -5, -4,-12, -3,  2, -6, -4,  0, -5,-11,  2, -6,  1,  0,  1, -9,  5, -3; D=-5;
/I:         I=-5; MI=-25; MD=-25; IM=-25; DM=-25;
/M: SY='G'; M=  0, -6,-17, -6,-11,-17, 40,-11,-23,-11,-17,-11,  0,-11,-11,-11,  0,-11,-17,-11,-17,-11; D=-5;
/I:         I=-5; MI=-25; IM=-25; DM=-25;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='K'; M= -4, -8,-22, -9, -6,-19, -8,-16,-16, 10,-15, -7, -6,-16, -6,  3, -2,  1, -6,-24,-13, -6;
/M: SY='H'; M= -9, -8, -3, -9,  1, -9,-21,  2,-18, -4,-16, -9, -6,-19, -6, -6, -2, -6,-10,-28, -7, -3;
/M: SY='E'; M=-12,  6,-27, 10, 22,-28,-19,  1,-22,  8,-17, -7,  1,-10, 22, 10, -1, -5,-22,-26,-13, 21;
/M: SY='F'; M= -8,-25,  3,-30,-28, 16,-16,-22,  3,-23,  2,  5,-21,-29,-28,-20,-13, -8, 12,-19, -3,-26;
/M: SY='P'; M= -5, -9,-25, -5,  6,-22,-19,-15,-14, -1,-20,-13, -9, 18, -4, -8,  2,  3,-10,-30,-19,  0;
/M: SY='R'; M=-10, -5,-25,-11,-11, -9,  1, -7,-18,  1,-15, -2,  2,-19, -6,  4, -6, -6,-15,-17, -5, -9;
/M: SY='E'; M= -9,  2,-26,  6, 17,-21,-21, -7,-10, -6, -6, -7, -3,-11,  8, -9, -3, -6,-13,-29,-13, 12;
/M: SY='A'; M= 13,  1,-19, -4,  6,-24,-11,-10,-18,  6,-18,-11,  2,-10,  6, -2,  6,  3,-13,-24,-16,  6;
/M: SY='L'; M=-11,-24,-25,-29,-19,  4,-30,-12, 22,-21, 24, 21,-22,-24, -8,-17,-22,-10,  9,-13, 10,-16;
/M: SY='Q'; M= -5,  0,-28,  0, 19,-35,-12,  2,-23, 11,-21, -6, -1, -9, 37,  7,  0,-10,-26,-21,-14, 28;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_11 which contains 556'196 sequence entries.


Total number of hits 86 in 59 different sequences
Number of true positive hits 86 in 59 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 8
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 91.49 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Feature key [info] ZN_FING
Feature description [info] TRAF-type
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
59 sequences

CYHR1_DROME (Q9VZV5    ), CYHR1_HUMAN (Q6ZMK1    ), CYHR1_MOUSE (Q9QXA1    ), 
CYHR1_RAT   (Q5BK76    ), CYR1A_XENLA (Q6GNX1    ), CYR1B_XENLA (Q2TAD9    ), 
DG17_DICDI  (P11467    ), FBX30_HUMAN (Q8TB52    ), FBX30_MOUSE (Q8BJL1    ), 
FBX30_RAT   (Q5XI67    ), FBX40_HUMAN (Q9UH90    ), FBX40_MOUSE (P62932    ), 
PZRN3_HUMAN (Q9UPQ7    ), PZRN3_MOUSE (Q69ZS0    ), PZRN3_RAT   (P68907    ), 
RN151_BOVIN (Q2TBT8    ), RN151_HUMAN (Q2KHN1    ), RN151_MOUSE (Q9CQ29    ), 
TRAD1_MOUSE (Q3UDK1    ), TRAD1_RAT   (Q99MM4    ), TRAF2_HUMAN (Q12933    ), 
TRAF2_MOUSE (P39429    ), TRAF3_HUMAN (Q13114    ), TRAF3_MOUSE (Q60803    ), 
TRAF4_HUMAN (Q9BUZ4    ), TRAF4_MOUSE (Q61382    ), TRAF5_HUMAN (O00463    ), 
TRAF5_MOUSE (P70191    ), TRAF6_BOVIN (Q3ZCC3    ), TRAF6_CERAT (B6CJY4    ), 
TRAF6_DANRE (Q6IWL4    ), TRAF6_HUMAN (Q9Y4K3    ), TRAF6_MACMU (B6CJY5    ), 
TRAF6_MOUSE (P70196    ), TRAF6_PIG   (A7XUJ6    ), TRAF6_RAT   (B5DF45    ), 
TRAF6_XENTR (Q28DL4    ), TRAF7_HUMAN (Q6Q0C0    ), TRAF7_MOUSE (Q922B6    ), 
TRF6A_XENLA (Q3MV19    ), TRF6B_XENLA (Q6DJN2    ), XAF1_HUMAN  (Q6GPH4    ), 
Y0883_DICDI (Q54FG0    ), Y0931_DICDI (Q54FD5    ), Y0965_DICDI (Q54FC5    ), 
Y0971_DICDI (Q54FB9    ), Y2098_DICDI (Q55A66    ), Y2340_DICDI (Q86AY4    ), 
Y2348_DICDI (Q86KX6    ), Y2829_DICDI (Q86L54    ), Y3202_DICDI (Q54C11    ), 
Y3435_DICDI (Q557K2    ), Y3509_DICDI (Q557K0    ), Y7243_DICDI (Q86K46    ), 
Y7744_DICDI (Q55GA8    ), Y7754_DICDI (Q55GA0    ), Y7813_DICDI (Q54YP8    ), 
Y8444_DICDI (Q1ZXR0    ), Y8514_DICDI (Q54NN4    )
» more

UniProtKB/Swiss-Prot
False negative sequences
8 sequences

CYHR1_BOVIN (Q7YR89    ), CYHR1_DANRE (Q08CH8    ), TRAD1_BOVIN (Q58D05    ), 
TRAD1_HUMAN (O14545    ), TRAD1_MACFA (Q4R970    ), XAF1_BOVIN  (Q58DH1    ), 
XAF1_MOUSE  (Q5NBU8    ), Y9745_DICDI (Q54WD3    )
» more

PDB
[Detailed view]
4 PDB

2EOD; 2YRE; 2YUC; 3HCS

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission