To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS. To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017. From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...] View this page in https
The 18 residues CCHC zinc finger is mainly found in the nucleocapsid protein
of retrovirus. It is required for viral genome packaging and for early
infection process [1,2]. It is also found in eukaryotic proteins involved in
RNA binding or single-stranded DNA binding.
Some proteins known to contain a CCHC zinc finger are listed below.
Retroviral GAG protein. Nucleocapside protein.
Human CNBP protein. CNBP is involved in sterol-mediated repression. It has
also been shown to bind the 5' untranslated region of ribosomal proteins
mRNA (a region known to be important in translational regulation).
Yeast BYR3; the CNBP homolog.
Caenorhabditis elegans protein glh-1; a probable ATP-binding RNA helicase.
Leishmania major hexamer-binding protein (HEXP). It binds the 5'
untranslated region of the GP63 gene.
Tobbacco transposon TNT1 PolX protein. Retrovirus-related pol polyprotein.
The profile we developed covers the whole domain.
January 2002 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Katz R.A., Jentoft J.E.
What is the role of the cys-his motif in retroviral nucleocapsid (NC) proteins?
PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
or see: prosite_license.html.