|PROSITE documentation PDOC50158
Zinc finger CCHC-type profile
The 18 residues CCHC zinc finger is mainly found in the nucleocapsid protein
of retrovirus. It is required for viral genome packaging and for early
infection process [1,2]. It is also found in eukaryotic proteins involved in
RNA binding or single-stranded DNA binding.
Some proteins known to contain a CCHC zinc finger are listed below.
- Retroviral GAG protein. Nucleocapside protein.
- Human CNBP protein. CNBP is involved in sterol-mediated repression. It has
also been shown to bind the 5' untranslated region of ribosomal proteins
mRNA (a region known to be important in translational regulation).
- Yeast BYR3; the CNBP homolog.
- Caenorhabditis elegans protein glh-1; a probable ATP-binding RNA helicase.
- Leishmania major hexamer-binding protein (HEXP). It binds the 5'
untranslated region of the GP63 gene.
- Tobbacco transposon TNT1 PolX protein. Retrovirus-related pol polyprotein.
The profile we developed covers the whole domain.
January 2002 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|ZF_CCHC, PS50158; Zinc finger CCHC-type profile (MATRIX)
|Sequences in UniProtKB/Swiss-Prot known to belong to this class detected by PS50158:
||404 true positives with 64 false negatives.
|Other sequence(s) in UniProtKB/Swiss-Prot detected by PS50158:
||1 false positive.
|Matching PDB structures:
1A6B 1AAF 1DSQ 1ESK ... [ALL]
||Katz R.A., Jentoft J.E.
||What is the role of the cys-his motif in retroviral nucleocapsid (NC) proteins?
||Urbaneja M.A., Kane B.P., Johnson D.G., Gorelick R.J., Henderson L.E., Casas-Finet J.R.
||Binding properties of the human immunodeficiency virus type 1 nucleocapsid protein p7 to a model RNA: elucidation of the structural determinants for function.
||J. Mol. Biol. 287:59-75(1999).
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