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PROSITE documentation PDOC50158

Zinc finger CCHC-type profile


The 18 residues CCHC zinc finger is mainly found in the nucleocapsid protein of retrovirus. It is required for viral genome packaging and for early infection process [1,2]. It is also found in eukaryotic proteins involved in RNA binding or single-stranded DNA binding.

Some proteins known to contain a CCHC zinc finger are listed below.

  • Retroviral GAG protein. Nucleocapside protein.
  • Human CNBP protein. CNBP is involved in sterol-mediated repression. It has also been shown to bind the 5' untranslated region of ribosomal proteins mRNA (a region known to be important in translational regulation).
  • Yeast BYR3; the CNBP homolog.
  • Caenorhabditis elegans protein glh-1; a probable ATP-binding RNA helicase.
  • Leishmania major hexamer-binding protein (HEXP). It binds the 5' untranslated region of the GP63 gene.
  • Tobbacco transposon TNT1 PolX protein. Retrovirus-related pol polyprotein.

The profile we developed covers the whole domain.

Last update:

January 2002 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

ZF_CCHC, PS50158; Zinc finger CCHC-type profile  (MATRIX)


1AuthorsKatz R.A., Jentoft J.E.
TitleWhat is the role of the cys-his motif in retroviral nucleocapsid (NC) proteins?
SourceBioEssays 11:176-181(1989).
PubMed ID2695083

2AuthorsUrbaneja M.A., Kane B.P., Johnson D.G., Gorelick R.J., Henderson L.E., Casas-Finet J.R.
TitleBinding properties of the human immunodeficiency virus type 1 nucleocapsid protein p7 to a model RNA: elucidation of the structural determinants for function.
SourceJ. Mol. Biol. 287:59-75(1999).
PubMed ID10074407

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