PROSITE documentation PDOC51073RPEL repeat profile
RPEL repeat (RPxxxEL) containing proteins are found in a wide range of metazoan organisms. RPEL repeats have been shown to be required for unpolymerized actin binding and proteins containing RPEL repeats are able to modify cell shape and/or are important in the regulation of gene expression by the actin cytoskeleton. RPEL repeats can be found in association with the SAP motif (see <PDOC50800>), which could be involved in DNA binding [1,2].
Some proteins known to contain RPEL repeats are listed below:
- Mammalian myocardin, heart-specific serum response factor (SRF) co- activator.
- Vertebrate myocardin-related transcription factor A (MRTF-A or MAL), a signal-regulated SRF co-activator.
- Vertebrate myocardin-related transcription factor B (MRTF-B).
- Mammalian phosphatase and actin regulator 1 to 3.
The profile we developed covers the entire RPEL repeat.
Last update:January 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Miralles F. Posern G. Zaromytidou A.-I. Treisman R. |
| Title | Actin dynamics control SRF activity by regulation of its coactivator MAL. | |
| Source | Cell 113:329-342(2003). | |
| PubMed ID | 12732141 |
| 2 | Authors | Favot L. Gillingwater M. Scott C. Kemp P.R. |
| Title | Overexpression of a family of RPEL proteins modifies cell shape. | |
| Source | FEBS Lett. 579:100-104(2005). | |
| PubMed ID | 15620697 | |
| DOI | 10.1016/j.febslet.2004.11.054 |
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