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The following proteins playing a role in anterograde transport from the
endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the
Golgi to the ER share sequence similarity:
Mammalian RINT1 (Rad50-interacting protein 1), which was originally
discovered as a checkpoint protein that interacts with Rad50 only during
late S and G2/M phases. RINT1 also functions in membrane trafficking from
the endoplasmic reticulum (ER) to the Golgi complex in interphase cells
Yeast TIP20, which has been reported to be involved in the retrograde
transport from the Golgi to the ER .
Arabidopsis thaliana MAIGO2 (MAG2), functions in the transport of storage
protein precursors between the ER and Golgi complex in plants .
They share a similar domain organization with an N-terminal leucine heptad
repeat rich coiled coil and an ~500-residue C-terminal RINT1/TIP20 domain,
which might be a protein-protein interaction module necessary for the
formation of functional complexes.
The profile we developed covers the entire RINT1/TIP20 domain.
May 2008 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Xiao J., Liu C.-C., Chen P.-L., Lee W.-H.
RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control.
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