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	PROSITE documentation PDOC51468

The inter-α-trypsin inhibitor (ITI) family is composed of protease inhibitors that are assembled from two precursor proteins: a light chain and different homologous heavy chains (ITIHs). Originally identified as plasma inhibitors, recent data indicate that ITI plays a role in extracellular matrix stabilization and in prevention of tumor metastasis [1].

Two domains are conserved in all known ITIHs, the vault protein inter-α-trypsin (VIT) domain and a von Willebrand type A (vWA) domain (see <PDOC50234>). The VIT domain is less widespread than the vWA domain and is not genetically mobile. Therefore, it can be regarded as the characteristic domain of the ITIH family. The VIT domain is approximately 135 amino acids long. Its N-terminal part contains a pattern of hydrophobic residues, interrupted by a conserved arginine. The C-terminus is best characterized by its conserved aromatic residues. In the central part, an acidic amino acid resides between two basic residues [1].

The profile we developed covers the entire VIT domain.

Last update:

October 2009 / First entry.

PROSITE method (with tools and information) covered by this documentation:

VIT, PS51468; VIT domain profile  (MATRIX)

• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 40
  • detected by PS51468: 40 (true positives)
  • undetected by PS51468: 0 (false negative or 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS51468:
  NONE.
• Domain architecture view of Swiss-Prot proteins matching PS51468
  
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS51468
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS51468
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS51468
• View ligand binding statistics of PS51468

1	Authors	Himmelfarb M., Klopocki E., Grube S., Staub E., Klaman I., Hinzmann B., Kristiansen G., Rosenthal A., Duerst M., Dahl E.
	Title	ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer.
	Source	Cancer Lett. 204:69-77(2004).
	PubMed ID	14744536

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