PROSITE documentation PDOC52031GG-type lectin domain profile
The GG domain, with two well-conserved glycine residues, is present in eukaryotic FAM3 superfamily (FAM3A, FAM3B, FAM3C and FAM3D), POMGnT1 (protein O-linked mannose β-1,2-N-acetylglucosaminyltransferase), TEM2 proteins as well as phage gp35 proteins. The presence of a GG domain in Bacteriophage gp35 hinge connector of long tail fiber might reflect the horizontal gene transfer from organisms [1,2]. The GG domain is a lectin with carbohydrate-binding activity [3,4].
The GG-type lectin domain exhibits a β-β-α three-layer architecture with two antiparallel β sheets and one layer of short helices (see <PDB:2YOP>. The core of the fold is mainly hydrophobic [2,3,4].
The profile we developed covers the entire GG-type lectin domain.
Last update:July 2023 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Guo J. Cheng H. Zhao S. Yu L. |
| Title | GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases. | |
| Source | FEBS. Lett. 580:581-584(2006). | |
| PubMed ID | 16406369 | |
| DOI | 10.1016/j.febslet.2005.12.076 |
| 2 | Authors | Johansson P. Bernstroem J. Gorman T. Oester L. Baeckstroem S. Schweikart F. Xu B. Xue Y. Schiavone L.H. |
| Title | FAM3B PANDER and FAM3C ILEI represent a distinct class of signaling molecules with a non-cytokine-like fold. | |
| Source | Structure 21:306-313(2013). | |
| PubMed ID | 23333428 | |
| DOI | 10.1016/j.str.2012.12.009 |
| 3 | Authors | Kuwabara N. Manya H. Yamada T. Tateno H. Kanagawa M. Kobayashi K. Akasaka-Manya K. Hirose Y. Mizuno M. Ikeguchi M. Toda T. Hirabayashi J. Senda T. Endo T. Kato R. |
| Title | Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of alpha-dystroglycan. | |
| Source | Proc. Natl. Acad. Sci. U. S. A. 113:9280-9285(2016). | |
| PubMed ID | 27493216 | |
| DOI | 10.1073/pnas.1525545113 |
| 4 | Authors | Niu M. McGrath M. Sammon D. Gardner S. Morgan R.M. Di Maio A. Liu Y. Bubeck D. Hohenester E. |
| Title | Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity. | |
| Source | Wellcome. Open. Res. 8:76-76(2023). | |
| PubMed ID | 37234743 | |
| DOI | 10.12688/wellcomeopenres.18937.2 |
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