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PROSITE entry PS00094


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General information about the entry

Entry name [info] C5_MTASE_1
Accession [info] PS00094
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00089
Associated ProRule [info] PRU10018

Name and characterization of the entry

Description [info] C-5 cytosine-specific DNA methylases active site.
Pattern [info]
[DENKS]-x-[FLIV]-x(2)-[GSTC]-x-P-C-x-{V}-[FYWLIM]-S.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 99 in 99 different sequences
Number of true positive hits 88 in 88 different sequences
Number of 'unknown' hits 0
Number of false positive hits 11 in 11 different sequences
Number of false negative sequences 15
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 88.89 %
Recall (true positives / (true positives + false negatives)) 85.44 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
88 sequences

CMT1_MAIZE  (Q9AXT8), CMT1_ORYSJ  (A0A0P0VUY4), CMT2_MAIZE  (Q9ARI6), 
CMT2_ORYSJ  (Q5KQL9), CMT3_ARATH  (Q94F88), CMT3_MAIZE  (Q8LPU5), 
CMT3_ORYSJ  (C0SQ89), DAM_BPP1(Q71TL0), DCM_ECO57   (P0AEE0), 
DCM_ECOLI   (P0AED9), DNM1A_ORYSJ (Q7Y1I7), DNM1B_ORYSJ (B1Q3J6), 
DNM3A_CHICK (Q4W5Z4), DNM3A_HUMAN (Q9Y6K1), DNM3A_MOUSE (O88508), 
DNM3A_RAT   (Q1LZ53), DNM3B_HUMAN (Q9UBC3), DNM3B_MOUSE (O88509), 
DNM3C_MOUSE (P0DOY1), DNMT1_ARATH (P34881), DNMT1_BOVIN (Q24K09), 
DNMT1_CHICK (Q92072), DNMT1_HUMAN (P26358), DNMT1_MOUSE (P13864), 
DNMT1_PARLI (Q27746), DNMT1_RAT   (Q9Z330), DNMT2_ARATH (Q9M0S8), 
DNMT3_ARATH (Q9T0I1), DNMT4_ARATH (O23273), DNMT_FRG3G  (Q67472), 
MT872_AERPE (Q9YDP3), MTA1_CELCE  (P31974), MTA1_THAGE  (P94147), 
MTAA_PICP2  (P34882), MTAP_ARTPN  (D4ZX35), MTB1_BACP9  (P0DW08), 
MTB1_BREBE  (P34905), MTB1_BREEP  (P10283), MTB1_HERAU  (P25262), 
MTB1_LYSSH  (P13906), MTB1_NEIGO  (Q59603), MTB5_NEIGO  (Q59605), 
MTB6_BACSF  (P43420), MTBA_ANEAE  (P19888), MTBB_BPSPB  (P09389), 
MTBF_BACIU  (P17044), MTBP_BACSU  (P68585), MTBP_BPPHT  (P68586), 
MTBR_BACIU  (P06530), MTBR_BPRH1  (P09915), MTBS_BPSPR  (P00476), 
MTC1_HERAU  (P25263), MTC1_PBCVI  (P36216), MTC2_HERAU  (P25264), 
MTD1_DESNO  (P05302), MTD1_HERAU  (P24600), MTD2_HERAU  (P25265), 
MTD5_DACSA  (P50185), MTE1_HERAU  (P25266), MTE2_ECOLX  (P05101), 
MTE8_ECOLX  (P50196), MTF1_FUSNU  (P34906), MTF7_NEIGO  (Q59606), 
MTG1_AVIVO  (P25282), MTG1_HERAU  (P25267), MTG2_AVIVO  (P25283), 
MTH1_HAEPH  (P05102), MTH2_HAEAE  (O30868), MTH2_HAEPA  (P15446), 
MTH3_HAEAE  (P20589), MTH5_HAEIN  (P45000), MTHA_HAEPH  (P50192), 
MTM1_MORSP  (P11408), MTM4_NEIGO  (P31033), MTN1_LENAE  (P50188), 
MTN4_NEILA  (P50182), MTNX_NEILA  (P24581), MTP1_PSYTA  (O33481), 
MTP2_NEIGO  (P08455), MTS1_SALIN  (P09795), MTS2_SHISO  (P34879), 
MTS3_STAAU  (P16668), MTS9_STAAU  (P23737), MTSA_LACLC  (P34877), 
MTSB_LACLC  (P34878), MTSI_SPISQ  (P15840), MTX2_XANOR  (P52311), 
YDIP_BACSU  (O34680)
» more

UniProtKB/Swiss-Prot
False negative sequences
15 sequences

DRM1L_ARATH (Q9LXE5), DRM2_ARATH  (Q9M548), MT36_OCEIH  (Q8EL95), 
MT51_METJA  (Q57983), MTA1_ACEPA  (O52702), MTD1_NEIMC  (Q9RLM4), 
MTHT_METTF  (P29567), MTM7_METJA  (Q58600), MTS1_STRAH  (O31073), 
PMT1M_SCHPO (P40999), TRDMT_BOVIN (Q7YS61), TRDMT_HUMAN (O14717), 
TRDMT_MOUSE (O55055), TRDMT_RAT   (Q4G073), YDIO_BACSU  (O34939)
» more

UniProtKB/Swiss-Prot
False positive sequences
11 sequences

AF111_ALTAL (Q50LG1), CCN5_HUMAN  (O76076), GATA_NEOSM  (Q2GEE7), 
MEND_PHOLL  (Q7N2K3), OOPDA_ARATH (Q94AM1), RTPR_LACAC  (Q5FMX8), 
RTPR_LACH4  (A8YW74), RTPR_LEVBA  (Q03PB4), SYA_METBU   (Q12U25), 
Y94X_SYNY3  (P77971), YME2_CANAL  (Q5A061)
» more

PDB
[Detailed view]
93 PDB

10MH; 1DCT; 1FJX; 1HMY; 1M0E; 1MHT; 1SKM; 1SVU; 2C7O; 2C7P; 2C7Q; 2C7R; 2HMY; 2HR1; 2I9K; 2QRV; 2UYC; 2UYH; 2UZ4; 2Z6Q; 2Z6U; 2ZCJ; 3AV4; 3AV5; 3AV6; 3EEO; 3MHT; 3PT6; 3PT9; 3PTA; 3SWR; 4DA4; 4FSX; 4FT2; 4FT4; 4MHT; 4U7P; 4U7T; 4WXX; 4YOC; 5CIY; 5GUT; 5GUV; 5LOD; 5MHT; 5WY1; 5YX2; 6BRR; 6F57; 6KDA; 6KDB; 6KDL; 6KDP; 6KDT; 6MHT; 6PA7; 6U8P; 6U8V; 6U8W; 6U8X; 6U90; 6U91; 6W89; 6W8B; 6W8D; 6W8J; 6W8V; 6W8W; 6X9I; 6X9J; 6X9K; 7MHT; 7SFC; 7SFD; 7SFE; 7SFF; 7SFG; 7UBU; 7V0E; 7X9D; 7XI9; 7XIB; 8EIH; 8EII; 8EIJ; 8EIK; 8MHT; 8TCI; 8TDR; 8TE1; 8TE3; 8TE4; 9MHT
» more