Entry: PS00110

Forthcoming changes to the profile format
General information about the entry

Entry name [info] PYRUVATE_KINASE
Accession [info] PS00110
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); JUL-1999 (DATA UPDATE); SEP-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00101

Name and characterization of the entry

Description [info] Pyruvate kinase active site signature.
Pattern [info]
[LIVAC]-x-[LIVM](2)-[SAPCV]-K-[LIV]-E-[NKRST]-x-[DEQHS]-[GSTA]-[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_10 which contains 546'790 sequence entries.


Total number of hits 84 in 84 different sequences
Number of true positive hits 79 in 79 different sequences
Number of 'unknown' hits
Number of false positive hits 5 in 5 different sequences
Number of false negative sequences 22
Number of 'partial' sequences 4
Precision (true positives / (true positives + false positives)) 94.05 %
Recall (true positives / (true positives + false negatives)) 78.22 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Site [info] magnesium at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
79 sequences

KPYA_RICCO  (Q43117), KPYA_TOBAC  (Q40545), KPYC_ARATH  (O65595), 
KPYC_SOLTU  (P22200), KPYC_SOYBN  (Q42806), KPYC_TOBAC  (Q42954), 
KPYG_RICCO  (P55964), KPYG_TOBAC  (Q40546), KPYK1_AGRVI (P70789), 
KPYK1_CANGA (Q6FIS9), KPYK1_ECO57 (P0AD62), KPYK1_ECOLI (P0AD61), 
KPYK1_SALTI (Q8Z6K2), KPYK1_SALTY (P77983), KPYK1_SYNY3 (Q55863), 
KPYK1_TRYBB (P30615), KPYK1_YEAST (P00549), KPYK2_AGRVI (Q44473), 
KPYK2_CANGA (Q6FV12), KPYK2_ECOLI (P21599), KPYK2_SALTY (Q8ZNW0), 
KPYK2_SYNY3 (P73534), KPYK2_TRYBB (P30616), KPYK2_YEAST (P52489), 
KPYK_AGABI  (O94122), KPYK_ASHGO  (Q759A9), KPYK_ASPNG  (Q12669), 
KPYK_BACLI  (P51181), KPYK_BACSU  (P80885), KPYK_BORBU  (O51323), 
KPYK_BUCAI  (P57404), KPYK_BUCAP  (Q8K9M3), KPYK_BUCBP  (Q89AI8), 
KPYK_CANAL  (P46614), KPYK_CLOPE  (Q46289), KPYK_COREF  (Q8FP04), 
KPYK_CORGL  (Q46078), KPYK_DEBHA  (Q6BS75), KPYK_DICDI  (Q54RF5), 
KPYK_DROME  (O62619), KPYK_EIMTE  (O44006), KPYK_EMENI  (P22360), 
KPYK_GEOSE  (Q02499), KPYK_HAEIN  (P43924), KPYK_HYPJE  (P31865), 
KPYK_KLULA  (Q875M9), KPYK_LACK1  (Q875S4), KPYK_LACLA  (Q07637), 
KPYK_LEIME  (Q27686), KPYK_METEA  (O05118), KPYK_METJA  (Q57572), 
KPYK_MYCGE  (P47458), KPYK_MYCIT  (P94939), KPYK_MYCPN  (P78031), 
KPYK_MYCTO  (P9WKE4), KPYK_MYCTU  (P9WKE5), KPYK_NAUCC  (Q875Z9), 
KPYK_NEUCR  (Q7RVA8), KPYK_SCHPO  (Q10208), KPYK_SPOPS  (P51182), 
KPYK_STAS1  (Q49YC7), KPYK_THELN  (Q56301), KPYK_TRYBO  (Q27788), 
KPYK_YARLI  (P30614), KPYM_CHICK  (P00548), KPYM_FELCA  (P11979), 
KPYM_HUMAN  (P14618), KPYM_MOUSE  (P52480), KPYM_PONAB  (Q5NVN0), 
KPYM_RABIT  (P11974), KPYM_RAT    (P11980), KPYM_XENLA  (Q92122), 
KPYR_CANFA  (Q29536), KPYR_HUMAN  (P30613), KPYR_MOUSE  (P53657), 
KPYR_RAT    (P12928), PKP1_ARATH  (Q9LIK0), PKP2_ARATH  (Q9FLW9), 
PKP3_ARATH  (Q93Z53)
» More

UniProtKB/Swiss-Prot
False negative sequences
22 sequences

KPYK_AERPE  (Q9YEU2), KPYK_CHLMU  (Q9PK61), KPYK_CHLPN  (Q9Z984), 
KPYK_CHLT2  (B0B7Q0), KPYK_CHLTR  (P0CE21), KPYK_CLOAB  (O08309), 
KPYK_LACDE  (P34038), KPYK_PYRAE  (Q8ZYE0), KPYK_STAA3  (Q2FG40), 
KPYK_STAA8  (Q2FXM9), KPYK_STAAB  (Q2YTE3), KPYK_STAAC  (Q5HF76), 
KPYK_STAAM  (Q99TG5), KPYK_STAAN  (Q7A559), KPYK_STAAR  (Q6GG09), 
KPYK_STAAS  (Q6G8M9), KPYK_STAAW  (Q7A0N4), KPYK_STAEQ  (Q5HNK7), 
KPYK_STAES  (Q8CS69), KPYK_STAHJ  (Q4L739), KPYK_THEAC  (P32044), 
KPYK_THEMA  (Q9WY51)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
4 sequences

KPYK1_PHOLE (O30853), KPYK_CLOPA  (P81344), KPYK_LEIBR  (Q04668), 
KPYK_SPICI  (P19680)
» More

UniProtKB/Swiss-Prot
False positive sequences
5 sequences

AROB_BRUA2  (Q2YR43), AROB_BRUAB  (Q57AM9), DNAB_HAEIN  (P45256), 
F206_DROME  (Q9VFR1), MQO_CAMJE   (P56954)
» More

PDB
[Detailed view]
59 PDB

1A3W; 1A3X; 1A49; 1A5U; 1AQF; 1E0T; 1E0U; 1F3W; 1F3X; 1PKL; 1PKM; 1PKN; 1PKY; 1T5A; 1ZJH; 2E28; 2G50; 2VGB; 2VGF; 2VGG; 2VGI; 3BJF; 3BJT; 3E0V; 3E0W; 3G2G; 3GQY; 3GR4; 3H6O; 3HQN; 3HQO; 3HQP; 3HQQ; 3IS4; 3KTX; 3ME3; 3N25; 3PP7; 3QV6; 3QV7; 3QV8; 3SRD; 3SRF; 3SRH; 3SRK; 3U2Z; 4B2D; 4FXF; 4FXJ; 4G1N; 4HYV; 4HYW; 4IMA; 4IP7; 4JPG; 4KCT; 4KCU; 4KCV; 4KCW
» More

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission