Entry: PS00141

Forthcoming changes to the profile format
General information about the entry

Entry name [info] ASP_PROTEASE
Accession [info] PS00141
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); DEC-2004 (DATA UPDATE); OCT-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00128
Associated ProRule [info] PRU10094

Name and characterization of the entry

Description [info] Eukaryotic and viral aspartyl proteases active site.
Pattern [info]
[LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-[STAPDENQ]-{GQ}-
[LIVMFSTNC]-{EGK}-[LIVMFGTA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_11 which contains 547'085 sequence entries.


Total number of hits 646 in 490 different sequences
Number of true positive hits 537 in 381 different sequences
Number of 'unknown' hits
Number of false positive hits 109 in 109 different sequences
Number of false negative sequences 24
Number of 'partial' sequences 45
Precision (true positives / (true positives + false positives)) 83.13 %
Recall (true positives / (true positives + false negatives)) 95.72 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 2
Site [info] active_site at position 4
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
381 sequences

APA1_ARATH  (O65390), APA2_ARATH  (Q8VYL3), APA3_ARATH  (Q9XEC4), 
APRV1_HUMAN (Q53RT3), APRV1_MOUSE (Q09PK2), ASP1_ORYSI  (A2ZC67), 
ASP1_ORYSJ  (Q0IU52), ASP3_CAEEL  (P55956), ASP6_CAEEL  (O01530), 
ASPG1_ARATH (Q9LS40), ASPG2_ARATH (Q9LHE3), ASPL1_ARATH (Q9LX20), 
ASPP_AEDAE  (Q03168), ASPR1_ARATH (Q3EBM5), ASPR1_ORYSJ (Q42456), 
ASPR1_PHARH (O60020), ASPRX_ORYSJ (P42211), ASPR_CUCPE  (O04057), 
ASPR_HORVU  (P42210), AXP1_YARLI  (Q92389), BACE1_BOVIN (Q2HJ40), 
BACE1_CAVPO (Q1KLR6), BACE1_HUMAN (P56817), BACE1_MOUSE (P56818), 
BACE1_RAT   (P56819), BACE2_HUMAN (Q9Y5Z0), BACE2_MOUSE (Q9JL18), 
BACE2_RAT   (Q6IE75), BAR1_YEAST  (P12630), CAR10_CANAL (Q5A651), 
CARDA_CYNCA (Q9XFX3), CARDB_CYNCA (Q9XFX4), CARDF_CYNCA (P85137), 
CARDG_CYNCA (P85138), CARDH_CYNCA (P85139), CARP1_CANAL (P0CY27), 
CARP1_CANAW (C4YSF6), CARP1_CANAX (P0CY26), CARP1_CANPA (P32951), 
CARP1_RHINI (P10602), CARP2_CANAL (P0DJ06), CARP2_CANAW (C4YMJ3), 
CARP2_CANAX (P0CS83), CARP2_CANPA (P32950), CARP2_RHINI (P43231), 
CARP3_CANAL (P0CY29), CARP3_CANAW (C4YNQ5), CARP3_CANAX (P0CY28), 
CARP3_RHINI (Q03699), CARP4_CANAL (Q5A8N2), CARP4_CANAW (P43093), 
CARP4_RHINI (Q03700), CARP5_CANAL (P43094), CARP5_RHINI (P43232), 
CARP6_CANAL (Q5AC08), CARP6_CANAX (P43095), CARP7_CANAL (Q59VH7), 
CARP7_CANAX (P43096), CARP8_CANAL (Q5AEM6), CARP8_CANAX (O42778), 
CARP9_CANAL (Q59SU1), CARP9_CANAX (O42779), CARPV_CANAX (P10977), 
CARP_ARTBC  (D4B385), CARP_ARTOC  (C5FS55), CARP_ASPFU  (O42630), 
CARP_CANTR  (Q00663), CARP_CRYPA  (P11838), CARP_IRPLA  (P17576), 
CARP_NEUCR  (Q01294), CARP_PODAS  (O13340), CARP_RHICH  (P06026), 
CARP_RHIMI  (P00799), CARP_RHIPU  (P09177), CARP_SACFI  (P22929), 
CARP_SYNRA  (P81214), CARP_TRIVH  (D4DEN7), CARP_YEAST  (P07267), 
CATD_BOVIN  (P80209), CATD_CANFA  (Q4LAL9), CATD_CHICK  (Q05744), 
CATD_CHIHA  (O93428), CATD_CLUHA  (Q9DEX3), CATD_DICDI  (O76856), 
CATD_HUMAN  (P07339), CATD_MOUSE  (P18242), CATD_PIG    (P00795), 
CATD_RAT    (P24268), CATD_SHEEP  (Q9MZS8), CATEA_XENLA (Q805F3), 
CATEB_XENLA (Q805F2), CATE_CAVPO  (P25796), CATE_HUMAN  (P14091), 
CATE_LITCT  (Q800A0), CATE_MOUSE  (P70269), CATE_RABIT  (P43159), 
CATE_RAT    (P16228), CDR1_ARATH  (Q6XBF8), CHYM_BOVIN  (P00794), 
CHYM_CALJA  (Q9N2D2), CHYM_SHEEP  (P18276), CTSD_ARTBC  (D4AZK1), 
CTSD_ARTOC  (C5FEK4), CTSD_TRIVH  (D4D8U6), CYPR1_CYNCA (P40782), 
GAG_AVIMA   (P26315), GAG_IPMA    (P11365), GAG_RSVP    (P03322), 
GAG_RSVSA   (P0C776), GAG_RSVSB   (O92954), MKC7_YEAST  (P53379), 
NAPSA_HUMAN (O96009), NAPSA_MOUSE (O09043), NEP1_NEPGR  (Q766C3), 
NEP2_NEPGR  (Q766C2), OPSB_ASPFU  (Q4WDN4), OPSB_ASPOR  (Q8NKB6), 
PAG1_BOVIN  (Q29432), PAG1_PIG    (Q29078), PAG1_SHEEP  (Q28755), 
PAG2_BOVIN  (Q28057), PAG2_PIG    (Q29079), PAG4_SHEEP  (P83495), 
PAG6_SHEEP  (P83493), PAG_HORSE   (Q28389), PCS1L_ARATH (Q9LZL3), 
PENP_PENJA  (P00798), PEP2B_GADMO (P56272), PEPA1_MACFU (P03954), 
PEPA1_RABIT (P28712), PEPA2_MACFU (P27677), PEPA2_RABIT (P27821), 
PEPA3_HUMAN (P0DJD8), PEPA3_RABIT (P27822), PEPA4_HUMAN (P0DJD7), 
PEPA4_MACFU (P27678), PEPA4_RABIT (P28713), PEPA5_HUMAN (P0DJD9), 
PEPAF_RABIT (P27823), PEPA_ARTBC  (D4ANC3), PEPA_ARTGP  (E5R1B9), 
PEPA_ARTOC  (C5FBS2), PEPA_ASPAW  (P17946), PEPA_ASPCL  (A1CBR4), 
PEPA_ASPFC  (B0Y1V8), PEPA_ASPFN  (B8NLY9), PEPA_ASPFU  (P41748), 
PEPA_ASPNC  (A2R3L3), PEPA_ASPNG  (P55325), PEPA_ASPOR  (Q06902), 
PEPA_ASPPH  (Q12567), PEPA_BOVIN  (P00792), PEPA_CALJA  (Q9N2D4), 
PEPA_CANFA  (Q9GMY6), PEPA_CHICK  (P00793), PEPA_COCP7  (C5PEI9), 
PEPA_EMENI  (O93885), PEPA_LEPMJ  (E5A7T3), PEPA_MACMU  (P11489), 
PEPA_NEOFI  (A1DDK1), PEPA_PENCW  (B6HL60), PEPA_PENJA  (P78735), 
PEPA_PENRO  (Q01972), PEPA_PHANO  (Q69IF8), PEPA_PIG    (P00791), 
PEPA_RHIFE  (Q9GMY7), PEPA_SORUN  (Q9GMY8), PEPA_SUNMU  (P81497), 
PEPA_TALSN  (B8MF81), PEPA_TRIVH  (D4D7C5), PEPB_CANFA  (Q8SQ41), 
PEPB_PENJA  (Q9HEZ3), PEPC_CALJA  (Q9N2D3), PEPC_CAVPO  (Q64411), 
PEPC_HUMAN  (P20142), PEPC_MACFU  (P03955), PEPC_MONDO  (Q689Z7), 
PEPC_MOUSE  (Q9D7R7), PEPC_RABIT  (Q9GMY2), PEPC_RAT    (P04073), 
PEPC_RHIFE  (Q9GMY3), PEPC_SORUN  (Q9GMY4), PEPC_SUNMU  (P81498), 
PEPE_CHICK  (P16476), PLM1_PLAF7  (Q7KQM4), PLM1_PLAFA  (P39898), 
PLM2_PLAFA  (P46925), POK9_HUMAN  (P63128), POL2_DROME  (P20825), 
POL3_DROME  (P04323), POL4_DROME  (P10394), POL_BAEVM   (P10272), 
POL_BIV29   (P19560), POL_CAEVC   (P33459), POL_COYMV   (P19199), 
POL_EIAV9   (P11204), POL_EIAVC   (P32542), POL_EIAVY   (P03371), 
POL_FIVPE   (P16088), POL_FIVSD   (P19028), POL_FIVT2   (P31822), 
POL_FLV     (P10273), POL_GALV    (P21414), POL_HTL1A   (P03362), 
POL_HTL1C   (P14078), POL_HTL1L   (P0C211), POL_HTL32   (Q0R5R2), 
POL_HTL3P   (Q4U0X6), POL_HTLV2   (P03363), POL_HV190   (O93215), 
POL_HV192   (O12158), POL_HV193   (O89290), POL_HV196   (Q9QBY3), 
POL_HV197   (Q9QBZ9), POL_HV19N   (O41798), POL_HV1A2   (P03369), 
POL_HV1AN   (Q77373), POL_HV1B1   (P03366), POL_HV1B5   (P04587), 
POL_HV1B9   (Q73368), POL_HV1BR   (P03367), POL_HV1C4   (P05960), 
POL_HV1EL   (P04589), POL_HV1ET   (Q75002), POL_HV1H2   (P04585), 
POL_HV1J3   (P12498), POL_HV1JR   (P20875), POL_HV1LW   (P0C6F2), 
POL_HV1M2   (Q9QBZ1), POL_HV1MA   (P04588), POL_HV1MN   (P05961), 
POL_HV1MP   (Q9QBZ5), POL_HV1MV   (Q79666), POL_HV1N5   (P12497), 
POL_HV1ND   (P18802), POL_HV1OY   (P20892), POL_HV1RH   (P05959), 
POL_HV1S2   (Q9WC54), POL_HV1S9   (Q9WC63), POL_HV1SE   (O89940), 
POL_HV1U4   (P24740), POL_HV1V9   (Q9Q720), POL_HV1VI   (Q9QSR3), 
POL_HV1Y2   (P35963), POL_HV1YB   (Q9IDV9), POL_HV1YF   (O91080), 
POL_HV1Z2   (P12499), POL_HV2BE   (P18096), POL_HV2CA   (P24107), 
POL_HV2D1   (P17757), POL_HV2D2   (P15833), POL_HV2EH   (Q89928), 
POL_HV2G1   (P18042), POL_HV2KR   (Q74120), POL_HV2RO   (P04584), 
POL_HV2SB   (P12451), POL_HV2ST   (P20876), POL_HV2UC   (Q76634), 
POL_JEMBR   (Q82851), POL_MLVAV   (P03356), POL_MLVF5   (P26810), 
POL_MLVFF   (P26809), POL_MLVFP   (P26808), POL_MLVMS   (P03355), 
POL_MLVRD   (P11227), POL_MMTVC   (P11283), POL_OMVVS   (P16901), 
POL_RSVP    (P03354), POL_RSVSA   (Q04095), POL_RSVSB   (O92956), 
POL_RTBVP   (P27502), POL_SIVCZ   (P17283), POL_SIVEK   (Q1A249), 
POL_SIVG1   (Q02836), POL_SIVGB   (P22382), POL_SIVM1   (P05896), 
POL_SIVMB   (Q1A267), POL_SIVMK   (P05897), POL_SIVS4   (P12502), 
POL_SIVSP   (P19505), POL_SIVTN   (Q8AII1), POL_SIVV1   (P27973), 
POL_SIVVG   (P27980), POL_SIVVT   (P05895), POL_VILV    (P03370), 
POL_VILV1   (P23426), POL_VILV2   (P23427), POL_VILVK   (P35956), 
POL_XMRV3   (Q2F7J3), POL_XMRV4   (Q2F7J0), POL_XMRV6   (A1Z651), 
PRO_HTL1A   (P10274), PRO_HTL1C   (P14074), PRO_HTL1L   (P0C210), 
PRO_HTL32   (Q0R5R3), PRO_HTL3P   (Q09SZ9), PRO_HTLV2   (P03353), 
PRO_MMTVC   (Q9IZT2), RENI1_MOUSE (P06281), RENI2_MOUSE (P00796), 
RENI_CALJA  (Q9TSZ1), RENI_CANFA  (Q6DYE7), RENI_HUMAN  (P00797), 
RENI_MACFA  (Q6DLS0), RENI_MACMU  (Q6DLW5), RENI_PANTR  (P60016), 
RENI_RAT    (P08424), RENI_SHEEP  (P52115), SXA1_SCHPO  (P32834), 
TF211_SCHPO (Q9UR07), TF212_SCHPO (P0CT41), TF21_SCHPO  (P0CT34), 
TF22_SCHPO  (P0CT35), TF23_SCHPO  (P0CT36), TF24_SCHPO  (P0CT37), 
TF25_SCHPO  (P0CT38), TF26_SCHPO  (P0CT39), TF27_SCHPO  (P0CT42), 
TF28_SCHPO  (P0CT43), TF29_SCHPO  (P0CT40), TY1AB_YEASX (Q07163), 
VP113_HUMAN (P63121), VPK10_HUMAN (P10265), VPK18_HUMAN (P63123), 
VPK19_HUMAN (P63120), VPK21_HUMAN (P63119), VPK24_HUMAN (P63129), 
VPK25_HUMAN (P63125), VPK6_HUMAN  (Q9Y6I0), VPK7_HUMAN  (P63131), 
VPK8_HUMAN  (P63122), VPK9_HUMAN  (P63127), VPRT_BLVJ   (P10270), 
VPRT_JSRV   (P31625), VPRT_MMTVB  (P10271), VPRT_MPMV   (P07570), 
VPRT_SMRVH  (P21407), VPRT_SRV1   (P04024), VPRT_SRV2   (P51518), 
Y1220_ASPFU (Q4WFS2), Y4018_ARTBC (D4AIC4), Y5382_TRIVH (D4DE18), 
Y5950_ASPFU (Q4WZS3), Y6366_TRIVH (D4DGR1), Y6955_ARTOC (C5FW52), 
Y7403_ARTBC (D4AT39), Y7979_ARTOC (C5FZ57), YB11B_YEAST (Q12490), 
YB12B_YEAST (Q12193), YD11B_YEAST (Q03855), YD12B_YEAST (Q99231), 
YD13B_YEAST (Q07793), YD14B_YEAST (P0C2I2), YD15B_YEAST (P0C2I3), 
YE11B_YEAST (Q03612), YE12B_YEAST (Q03619), YG11B_YEAST (Q12141), 
YG12B_YEAST (Q12269), YG13B_YEAST (Q12316), YH11B_YEAST (O13535), 
YJ11B_YEAST (P47098), YJ12B_YEAST (P47100), YL11B_YEAST (Q12088), 
YL12B_YEAST (P0C2I5), YL13B_YEAST (P0C2I6), YL14B_YEAST (P0C2I7), 
YM11B_YEAST (Q04711), YM12B_YEAST (Q03434), YM13B_YEAST (Q04214), 
YM14B_YEAST (Q04670), YN11B_YEAST (Q12112), YN12B_YEAST (Q99337), 
YO11B_YEAST (Q12273), YO12B_YEAST (Q92393), YP11B_YEAST (Q12414), 
YP12B_YEAST (P0C2I9), YP13B_YEAST (P0C2J0), YP14B_YEAST (P0C2J1), 
YPS1_YEAST  (P32329), YPS3_YEAST  (Q12303), YPS6_YEAST  (P40583)
» More

UniProtKB/Swiss-Prot
False negative sequences
24 sequences

ASP2_BLAGE  (P54958), ASPL2_ARATH (Q9S9K4), COPIA_DROME (P04146), 
GAG_IPHA    (P04023), OPSB_ARTBC  (D4AIS3), OPSB_ARTOC  (C5FRQ0), 
OPSB_TRIVH  (D4DFT3), POL_CAMVC   (P03555), POL_CAMVD   (P03556), 
POL_CAMVE   (Q02964), POL_CAMVN   (Q00962), POL_CAMVS   (P03554), 
POL_CERV    (P05400), POL_CSVMV   (Q89703), POL_FFV     (O93209), 
POL_FOAMV   (P14350), POL_HV2NZ   (P05962), POL_SFV1    (P23074), 
POL_SFV3L   (P27401), POL_WDSV    (O92815), VPK04_HUMAN (P63124), 
YA11B_YEAST (O13527), YPS1_SCHPO  (O59774), YPS7_YEAST  (Q06325)
» More

UniProtKB/Swiss-Prot
'Partial' sequences
45 sequences

CARDE_CYNCA (P85136), CHYM_FELCA  (P09873), NEP1_NEPDI  (P69476), 
NEP2_NEPDI  (P69477), PA39C_DAMDA (C0HJC9), PA50C_BISBO (P85321), 
PA50F_BISBO (P85324), PA50I_BISBO (P85327), PA55B_BISBO (P85320), 
PA55E_BISBO (P85323), PA55H_SHEEP (P83500), PA56B_DAMDA (C0HJC8), 
PA56D_DAMDA (C0HJD0), PA59G_SHEEP (P83499), PA60H_BISBO (P85326), 
PA61B_SHEEP (P83494), PA61C_BUBBU (P86374), PA62A_DAMDA (C0HJC7), 
PA63J_BUBBU (P86370), PA66E_SHEEP (P83497), PA67A_BISBO (P85319), 
PA71D_BISBO (P85322), PA71G_BISBO (P85325), PA73B_BUBBU (P86373), 
PAG55_CAPHI (P80935), PAG55_SHEEP (P83202), PAG57_SHEEP (P83203), 
PAG59_CAPHI (P80934), PAG59_SHEEP (P83444), PAG62_BUBBU (P86371), 
PAG62_CAPHI (P80933), PAG67_BOSIN (P83126), PAG70_BUBBU (P85049), 
PAG72_BISBI (P84916), PAG74_BISBI (P84917), PAG75_BUBBU (P85048), 
PAG76_BISBI (P84918), PEP1_THUOR  (P20139), PEP2_THUOR  (P20140), 
PEP3_THUOR  (P20141), PEPA_URSTH  (P13636), PEPC_PIG    (P30879), 
POL_HV1Z6   (P04586), POL_SIVV2   (P12500), POL_SIVV3   (P12501)
» More

UniProtKB/Swiss-Prot
False positive sequences
109 sequences

A30BL_HUMAN (A7E2S9), ACL6A_HUMAN (O96019), ACL6A_MACFA (Q4R333), 
ACL6A_MOUSE (Q9Z2N8), ACL6B_BOVIN (A4FUX8), ACL6B_HUMAN (O94805), 
ACL6B_MOUSE (Q99MR0), ACL6B_RAT   (P86173), AN30A_HUMAN (Q9BXX3), 
ARP4_YARLI  (Q6C061), ATPE_IDILO  (Q5QZH3), ATZN_ECOLI  (P37617), 
BCSB_XANAC  (P58933), BLAC_BACLI  (P00808), CAC1A_APIME (C9D7C2), 
CDC13_YEAST (P32797), CIMA_STRCO  (O86511), CINC_CITBR  (Q8VQF4), 
CP_CSVMV    (Q66283), CTP5A_MOUSE (Q0V8T9), CYOE_KLEP7  (A6T5H1), 
CYOE_SALAR  (A9MM32), CYOE_SALCH  (Q57SC4), CYOE_SALPA  (Q5PFP5), 
CYOE_SALPB  (A9MWZ0), CYOE_SALTI  (Q8Z8V5), CYOE_SALTY  (Q8ZRC4), 
DBP3_CANAL  (Q5APT8), DDI1_CHAGB  (Q2H085), DDI1_NEUCR  (Q7S906), 
DOIS_BACCI  (Q9S5E2), DUSB_PECCA  (O52539), DUSB_PROVU  (O52533), 
EPIP_STAEP  (P30199), EXB12_ORYSJ (Q10G40), FTSQ_RHOM4  (D0MGK7), 
GATR_ECOLI  (P36930), GGGPS_ARCFU (O29844), GGGPS_UNCMA (Q0W6K5), 
GRB1L_HUMAN (Q9C091), GRB1L_MOUSE (B9EJV3), HXK3_HUMAN  (P52790), 
HXK3_MOUSE  (Q3TRM8), HXK3_RAT    (P27926), IF2_MYXXD   (Q1DAM6), 
ISP4_SCHPO  (P40900), K1109_HUMAN (Q2LD37), K1109_MOUSE (A2AAE1), 
KEX1_CRYGW  (E6R6G5), KTRB_BACSU  (O32081), LPXH_XANAC  (P58975), 
M28P1_PENMQ (B6Q656), M28P1_SCLS1 (A7F4S1), M28P1_TALSN (B8M853), 
MADCA_MOUSE (Q61826), MCP_SUHVS   (Q00705), MDTD_CITK8  (A8AEE4), 
MIAB_GEOBB  (B5EE49), MP_ACLSA    (P54892), MP_ACLSP    (P27739), 
MYO1_COPC7  (A8N2Y6), MYO1_CRYNB  (P0CP01), MYO1_CRYNJ  (P0CP00), 
NAGTA_MOUSE (Q8VCV9), NAGTC_MOUSE (Q3UN21), NRIP2_HUMAN (Q9BQI9), 
NRIP2_MOUSE (Q9JHR9), NROR_CLOAB  (Q9AL95), PMK_STRC1   (Q9KWG3), 
RAP1_YEAST  (P11938), RIPK4_HUMAN (P57078), RL20_BORBU  (O51206), 
RPOB_DECAR  (Q47JB0), RPOB_PARD8  (A6LE81), RPOB_THICR  (Q31IY9), 
RS15_CHESB  (Q11BC4), RS15_THIDA  (Q3SKX4), RSMB_PECAS  (Q6D000), 
RSMH_AGRVS  (B9JY62), RTL1_BOVIN  (Q52QI2), SDS23_ASPNC (A2RB71), 
SHOC2_NEMVE (A7SFP1), SMTA_ASTBI  (P56707), TCPQ_BOVIN  (Q3ZCI9), 
TCPQ_CHICK  (Q6EE31), TCPQ_HUMAN  (P50990), TCPQ_MACFA  (Q4R5J0), 
TCPQ_PONAB  (Q5RAP1), TGT_AROAE   (Q5P720), TPD52_MOUSE (Q62393), 
TPIS_NEIMA  (Q9JW31), TPIS_NEIMB  (Q9JXT8), TRYP_ASTAS  (P00765), 
V228_FOWPN  (Q9J507), WAAE_KLEPN  (Q9XC90), WPRA_BACSU  (P54423), 
Y1543_BACSK (Q5WHS7), Y2188_DICDI (Q54DL7), Y2496_BACA2 (A7Z780), 
Y2622_HALWD (Q18H12), Y4391_ARATH (Q9T020), Y7_SOCMV    (P15634), 
Y867_RICPR  (Q9ZC99), Y987_METTH  (O27068), YBGS_ECOLI  (P0AAV6), 
YBGS_SHIFL  (P0AAV7), YCBV_PSEDE  (P29938), YODS_BACSU  (O34317), 
YSZB_BACSU  (P21204)
» More


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