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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00972


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PURL: https://purl.expasy.org/prosite/signature/PS00972

Direct ScanProsite submission
General information about the entry

Entry name [info] USP_1
Accession [info] PS00972
Entry type [info] PATTERN
Date [info] 01-JUN-1994 CREATED;
01-DEC-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00750
Associated ProRule [info] PRU10092

Name and characterization of the entry

Description [info] Ubiquitin specific protease (USP) domain signature 1.
Pattern [info] 
G-[LIVMFY]-x(1,3)-[AGCY]-[NASMQG]-x-C-[FYWC]-[LIVMFCA]-[NSTAD]-[SACV]-x-
[LIVMSF]-[QF].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 298 in 298 different sequences
Number of true positive hits 298 in 298 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 29
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 91.13 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 298 sequences 

CREB_ASPCL  (A1CIL1), CREB_ASPFC  (B0Y4P5), CREB_ASPFN  (B8NSV5), 

CREB_ASPFU  (Q4WQI1), CREB_ASPNC  (A2Q9N1), CREB_ASPOR  (Q2UUG8), 
CREB_ASPTN  (Q0CT11), CREB_EMENI  (Q96V54), CREB_NEOFI  (A1CW53), 
CYLD_BOVIN  (Q1RMU2), CYLD_HUMAN  (Q9NQC7), CYLD_MOUSE  (Q80TQ2), 
CYLD_PONAB  (Q5RED8), CYLD_RAT(Q66H62), FAF_DROME   (P55824), 
FLA_ORYSJ   (Q2R4I5), NOT_DROME   (Q9VVR1), PUF_DROME   (Q9VC56), 
U17L5_HUMAN (A8MUK1), U17L6_HUMAN (Q6QN14), U17L8_HUMAN (P0C7I0), 
U17LA_HUMAN (C9JJH3), U17LB_HUMAN (C9JVI0), U17LC_MOUSE (G5E8I7), 
U17LD_HUMAN (C9JLJ4), U17LF_HUMAN (C9J2P7), U17LH_HUMAN (D6RBQ6), 
U17LI_HUMAN (D6R9N7), U17LJ_HUMAN (D6RCP7), U17LK_HUMAN (D6RJB6), 
U17LL_HUMAN (D6R901), U17LM_HUMAN (D6RA61), U17LN_HUMAN (D6RBM5), 
U17LO_HUMAN (Q0WX57), U17PA_MOUSE (Q61068), U17PB_MOUSE (E9Q9U0), 
U17PD_MOUSE (G5E8G2), U17PE_MOUSE (Q7M764), UB10A_XENLA (Q2NL57), 
UB10B_XENLA (Q7ZXR7), UB12A_XENLA (Q52KZ6), UB12B_XENLA (Q5M981), 
UB22A_XENLA (Q6GNI6), UB22B_XENLA (Q6DCJ1), UBP10_ARATH (Q9ZSB5), 
UBP10_BOVIN (A5PJS6), UBP10_CHICK (Q5ZJN4), UBP10_HUMAN (Q14694), 
UBP10_MOUSE (P52479), UBP10_RAT   (Q3KR59), UBP10_XENTR (Q6DIJ4), 
UBP11_ARATH (Q9MAQ3), UBP11_HUMAN (P51784), UBP11_MOUSE (Q99K46), 
UBP11_RAT   (Q5D006), UBP11_YEAST (P36026), UBP12_ARATH (Q9FPT1), 
UBP12_BOVIN (A5D9H7), UBP12_DANRE (A4FUN7), UBP12_HUMAN (O75317), 
UBP12_MOUSE (Q9D9M2), UBP12_RAT   (D0RB01), UBP12_SALSA (C0HB46), 
UBP12_SCHPO (O60079), UBP12_YEAST (P39538), UBP13_ARATH (Q84WU2), 
UBP13_BOVIN (E1BMF7), UBP13_CHICK (E1BY77), UBP13_HUMAN (Q92995), 
UBP13_MOUSE (Q5BKP2), UBP13_YEAST (P38187), UBP14_ARATH (Q8L6Y1), 
UBP14_BOVIN (Q0IIF7), UBP14_CAEEL (Q17361), UBP14_HUMAN (P54578), 
UBP14_MOUSE (Q9JMA1), UBP14_PANTR (P60051), UBP14_RABIT (P40826), 
UBP14_SCHPO (Q11119), UBP14_YEAST (P38237), UBP15_ARATH (Q9FPS9), 
UBP15_BOVIN (Q2HJE4), UBP15_HUMAN (Q9Y4E8), UBP15_MOUSE (Q8R5H1), 
UBP15_ORYSJ (Q0E2F9), UBP15_RAT   (Q9R085), UBP15_XENTR (F6Z5C0), 
UBP15_YEAST (P50101), UBP16_ARATH (Q9SB51), UBP16_BOVIN (Q08DA3), 
UBP16_DANRE (A8HAL1), UBP16_EMENI (P0CAQ1), UBP16_HUMAN (Q9Y5T5), 
UBP16_MACFA (Q4R6X7), UBP16_MOUSE (Q99LG0), UBP16_RAT   (Q2KJ09), 
UBP16_SCHPO (O74442), UBP16_XENLA (Q6PAW2), UBP16_XENTR (Q0VA64), 
UBP16_YEAST (Q02863), UBP17_ARATH (Q9FKP5), UBP18_ARATH (Q67XW5), 
UBP18_HUMAN (Q9UMW8), UBP18_MOUSE (Q9WTV6), UBP18_PONAB (Q5RE63), 
UBP19_ARATH (Q9SJA1), UBP19_HUMAN (O94966), UBP19_MOUSE (Q3UJD6), 
UBP19_RAT   (Q6J1Y9), UBP1_ARATH  (Q9FPT5), UBP1_BOVIN  (Q29RP1), 
UBP1_HUMAN  (O94782), UBP1_MOUSE  (Q8BJQ2), UBP1_RAT(Q569C3), 
UBP1_SCHPO  (Q9USM5), UBP1_YEAST  (P25037), UBP20_ARATH (Q9FPS7), 
UBP20_BOVIN (A7Z056), UBP20_DANRE (A5PN09), UBP20_HUMAN (Q9Y2K6), 
UBP20_MOUSE (Q8C6M1), UBP20_PONAB (Q5R5Z6), UBP20_XENLA (B1WBD7), 
UBP20_XENTR (A0JM59), UBP21_ARATH (Q9FIQ1), UBP21_BOVIN (Q2KJ72), 
UBP21_HUMAN (Q9UK80), UBP21_MOUSE (Q9QZL6), UBP21_RAT   (B2GUX4), 
UBP22_ARATH (Q9LEW0), UBP22_BOVIN (P0C8Z3), UBP22_DANRE (A6H8I0), 
UBP22_HUMAN (Q9UPT9), UBP22_MOUSE (Q5DU02), UBP23_ARATH (Q9FPS4), 
UBP24_ARATH (Q9FPS3), UBP24_HUMAN (Q9UPU5), UBP24_MOUSE (B1AY13), 
UBP25_ARATH (Q9FPS2), UBP25_HUMAN (Q9UHP3), UBP25_MOUSE (P57080), 
UBP26_ARATH (Q9SCJ9), UBP26_HUMAN (Q9BXU7), UBP26_MOUSE (Q99MX1), 
UBP26_ORYSI (A2XDG4), UBP26_ORYSJ (A3AF13), UBP27_ARATH (Q9FPS0), 
UBP27_HUMAN (A6NNY8), UBP27_MOUSE (Q8CEG8), UBP28_CHICK (Q5ZID5), 
UBP28_HUMAN (Q96RU2), UBP28_MOUSE (Q5I043), UBP28_RAT   (D3ZJ96), 
UBP29_HUMAN (Q9HBJ7), UBP29_MOUSE (Q9ES63), UBP2_ARATH  (Q8W4N3), 
UBP2_BOVIN  (Q2KHV7), UBP2_CHICK  (O57429), UBP2_DROME  (Q8IQ27), 
UBP2_HUMAN  (O75604), UBP2_KLULA  (O42726), UBP2_MOUSE  (O88623), 
UBP2_RAT(Q5U349), UBP2_SCHPO  (Q9P3U0), UBP2_YEAST  (Q01476), 
UBP30_DANRE (A2BGT0), UBP30_HUMAN (Q70CQ3), UBP30_MOUSE (Q3UN04), 
UBP30_RAT   (D3ZPG5), UBP30_XENTR (A4QNN3), UBP31_HUMAN (Q70CQ4), 
UBP32_DROME (M9PD06), UBP32_HUMAN (Q8NFA0), UBP32_MOUSE (F8VPZ3), 
UBP33_BOVIN (A6QNM7), UBP33_DANRE (A5PMR2), UBP33_HUMAN (Q8TEY7), 
UBP33_MOUSE (Q8R5K2), UBP33_PONAB (Q5REG5), UBP33_XENTR (Q28CN3), 
UBP34_HUMAN (Q70CQ2), UBP34_MOUSE (Q6ZQ93), UBP35_HUMAN (Q9P2H5), 
UBP36_DROAN (B3M3M6), UBP36_DROER (B3NC86), UBP36_DROGR (B4IXE0), 
UBP36_DROME (Q9VRP5), UBP36_DROMO (B4KXJ5), UBP36_DROPS (Q2LZB1), 
UBP36_DROSE (B4HUI5), UBP36_DROSI (B4QIS3), UBP36_DROVI (B4LG38), 
UBP36_DROWI (B4MLR8), UBP36_DROYA (B4PIW8), UBP36_HUMAN (Q9P275), 
UBP36_MOUSE (B1AQJ2), UBP37_BOVIN (F1N5V1), UBP37_CANLF (E2RK09), 
UBP37_CHICK (E1C213), UBP37_DANRE (E7F6T8), UBP37_HUMAN (Q86T82), 
UBP37_MOUSE (Q8C0R0), UBP37_PIG   (F1SRY5), UBP38_HUMAN (Q8NB14), 
UBP38_MOUSE (Q8BW70), UBP3_ARATH  (O24454), UBP3_HUMAN  (Q9Y6I4), 
UBP3_MOUSE  (Q91W36), UBP3_SCHPO  (O94269), UBP3_YEAST  (Q01477), 
UBP40_HUMAN (Q9NVE5), UBP40_MOUSE (Q8BWR4), UBP42_BOVIN (E1B9W9), 
UBP42_HUMAN (Q9H9J4), UBP42_MOUSE (B2RQC2), UBP42_RAT   (D3ZU96), 
UBP43_HUMAN (Q70EL4), UBP43_MOUSE (Q8BUM9), UBP44_AILME (D2HBJ8), 
UBP44_DANRE (Q7ZUM8), UBP44_HUMAN (Q9H0E7), UBP44_MOUSE (Q8C2S0), 
UBP44_XENTR (Q0V9G5), UBP45_DANRE (E9QG68), UBP45_HUMAN (Q70EL2), 
UBP45_MOUSE (Q8K387), UBP46_CAEEL (P34547), UBP46_DANRE (A5WWB0), 
UBP46_HUMAN (P62068), UBP46_MOUSE (P62069), UBP46_PONAB (Q5RBQ4), 
UBP46_RAT   (F1M625), UBP47_CHICK (E1C1R4), UBP47_HUMAN (Q96K76), 
UBP47_MOUSE (Q8BY87), UBP47_XENLA (Q5U252), UBP47_XENTR (A1A5G2), 
UBP48_CAEEL (G5ECC7), UBP49_HUMAN (Q70CQ1), UBP49_MOUSE (Q6P9L4), 
UBP4_ARATH  (Q8LAM0), UBP4_BOVIN  (A6QR55), UBP4_CANGA  (Q6FQF0), 
UBP4_EREGS  (Q754R5), UBP4_HUMAN  (Q13107), UBP4_KLULA  (Q9HFS7), 
UBP4_MOUSE  (P35123), UBP4_PONAB  (Q5RCD3), UBP4_RAT(B2GUZ1), 
UBP4_SCHPO  (O60139), UBP4_VANPO  (A7TGY3), UBP4_YEAS1  (B3LGK1), 
UBP4_YEAS7  (A6ZY34), UBP4_YEAST  (P32571), UBP50_HUMAN (Q70EL3), 
UBP50_MACFA (Q4R6D3), UBP50_MOUSE (Q6P8X6), UBP51_HUMAN (Q70EK9), 
UBP51_MOUSE (B1AY15), UBP5_ARATH  (O22207), UBP5_HUMAN  (P45974), 
UBP5_MOUSE  (P56399), UBP5_YEAST  (P39944), UBP64_DROME (Q9W4C3), 
UBP6_ARATH  (Q949Y0), UBP6_HUMAN  (P35125), UBP6_SCHPO  (Q92353), 
UBP6_YEAST  (P43593), UBP71_SCHPO (Q9UTT1), UBP72_SCHPO (Q09879), 
UBP7_ARATH  (Q84WC6), UBP7_CAEBR  (Q60MK8), UBP7_CAEEL  (Q7JKC3), 
UBP7_CHICK  (Q6U7I1), UBP7_DROME  (Q9VYQ8), UBP7_HUMAN  (Q93009), 
UBP7_MOUSE  (Q6A4J8), UBP7_RAT(Q4VSI4), UBP7_SCHPO  (Q9P7S5), 
UBP7_YEAST  (P40453), UBP8_ARATH  (Q9C585), UBP8_HUMAN  (P40818), 
UBP8_MOUSE  (Q80U87), UBP8_SCHPO  (Q09738), UBP8_YEAST  (P50102), 
UBP9_ARATH  (Q93Y01), UBP9_YEAST  (P39967), UBPA_DICDI  (P54201), 
UBPE_DROME  (Q24574), UBPL1_MIMIV (Q5UQR3), UBPY_CAEEL  (Q09931), 
UL17C_HUMAN (C9JPN9), UP44A_XENLA (Q6NTR6), UP44B_XENLA (Q5XGZ2), 
USP9X_HUMAN (Q93008), USP9X_MOUSE (P70398), USP9Y_HUMAN (O00507), 
USP9Y_MOUSE (F8VPU6)
» more

UniProtKB/Swiss-Prot
False negative sequences		 29 sequences 

U17L1_HUMAN (Q7RTZ2), U17L2_HUMAN (Q6R6M4), U17L3_HUMAN (A6NCW0), 

U17L4_HUMAN (A6NCW7), U17L7_HUMAN (P0C7H9), UBP10_SCHPO (Q9USR2), 
UBP10_YEAST (P53874), UBP11_SCHPO (Q9UUD6), UBP13_DANRE (F1QFS9), 
UBP13_XENTR (F6V6I0), UBP30_DROME (Q9W462), UBP39_HUMAN (Q53GS9), 
UBP39_MOUSE (Q3TIX9), UBP39_PONAB (Q5R761), UBP48_CHICK (Q5ZM45), 
UBP48_HUMAN (Q86UV5), UBP48_MOUSE (Q3V0C5), UBP48_RAT   (Q76LT8), 
UBP54_HUMAN (Q70EL1), UBP54_MOUSE (Q8BL06), UBP54_RAT   (Q6IE24), 
UBP5_PONAB  (Q5R407), UBP9_SCHPO  (Q9P7V9), UBPB_DICDI  (O96612), 
UBPH_CAEEL  (Q8WT44), UBPL2_MIMIV (Q5UPW7), USPL1_DANRE (Q6DRC5), 
USPL1_HUMAN (Q5W0Q7), USPL1_MOUSE (Q3ULM6)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

UBP11_CANLF (Q01988)


				
	

	

		PDB
[Detailed view]		
		
			149 PDB
			


			pdb_00001nb8; pdb_00001nbf; pdb_00001vjv; pdb_00002ayn; pdb_00002ayo; pdb_00002f1z; pdb_00002gfo; pdb_00002hd5; pdb_00002ibi; pdb_00002vhf; pdb_00002y5b; pdb_00002y6e; 
			
				pdb_00003i3t; pdb_00003ihp; pdb_00003m99; pdb_00003mhh; pdb_00003mhs; pdb_00003mtn; pdb_00003n3k; pdb_00003nhe; pdb_00003v6c; pdb_00003v6e; pdb_00004fip; pdb_00004fjc; 
				pdb_00004fk5; pdb_00004m5w; pdb_00004m5x; pdb_00004wa6; pdb_00005a5b; pdb_00005cht; pdb_00005chv; pdb_00005cvm; pdb_00005cvn; pdb_00005cvo; pdb_00005fwi; pdb_00005gjq; 
				pdb_00005j7t; pdb_00005jtj; pdb_00005jtv; pdb_00005k16; pdb_00005k1a; pdb_00005k1b; pdb_00005k1c; pdb_00005kyb; pdb_00005kyc; pdb_00005kyd; pdb_00005kye; pdb_00005kyf; 
				pdb_00005l8h; pdb_00005l8w; pdb_00005mpc; pdb_00005n9r; pdb_00005n9t; pdb_00005nge; pdb_00005ngf; pdb_00005o71; pdb_00005ohk; pdb_00005ohn; pdb_00005uqv; pdb_00005uqx; 
				pdb_00005vs6; pdb_00005vsb; pdb_00005vsk; pdb_00005wch; pdb_00005whc; pdb_00005xu8; pdb_00006cpm; pdb_00006crn; pdb_00006dgf; pdb_00006f5h; pdb_00006gh9; pdb_00006gha; 
				pdb_00006h4h; pdb_00006h4i; pdb_00006h4j; pdb_00006heh; pdb_00006hei; pdb_00006hej; pdb_00006hek; pdb_00006hel; pdb_00006iik; pdb_00006iil; pdb_00006iim; pdb_00006iin; 
				pdb_00006jlq; pdb_00006m1k; pdb_00006ml1; pdb_00006t9l; pdb_00006vn2; pdb_00006vn3; pdb_00006vn4; pdb_00006vn5; pdb_00006vn6; pdb_00007ay0; pdb_00007ay2; pdb_00007cm2; 
				pdb_00007qo4; pdb_00007qo5; pdb_00007r2g; pdb_00007tuo; pdb_00007w37; pdb_00007w38; pdb_00007w39; pdb_00007w3a; pdb_00007w3b; pdb_00007w3c; pdb_00007w3f; pdb_00007w3g; 
				pdb_00007w3h; pdb_00007w3i; pdb_00007w3j; pdb_00007w3k; pdb_00007w3m; pdb_00007w3r; pdb_00007w3u; pdb_00007xhh; pdb_00007xhk; pdb_00007yxx; pdb_00007yxy; pdb_00008bs3; 
				pdb_00008bs9; pdb_00008d0a; pdb_00008d1t; pdb_00008d4z; pdb_00008hje; pdb_00008p14; pdb_00008p19; pdb_00008p1p; pdb_00008p1q; pdb_00008wg5; pdb_00008xpn; pdb_00009dek; 
				pdb_00009del; pdb_00009dem; pdb_00009den; pdb_00009deo; pdb_00009dep; pdb_00009ebs; pdb_00009fio; pdb_00009fip; pdb_00009fiq; pdb_00009fir; pdb_00009fis; pdb_00009fit; 
				pdb_00009fiu; pdb_00009fiv; pdb_00009hnw; pdb_00009iju; pdb_00009iml
			
			

			» more