Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS01121

General information about the entry

Entry name [info] CASPASE_HIS
Accession [info] PS01121
Entry type [info] PATTERN
Date [info] 01-NOV-1995 CREATED; 01-DEC-2004 DATA UPDATE; 20-DEC-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC00864

Name and characterization of the entry

Description [info] Caspase family histidine active site.
Pattern [info]
H-x(2,4)-[SC]-x(2)-{A}-x-[LIVMF](2)-[ST]-H-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_12 which contains 556'388 sequence entries.


Total number of hits 64 in 64 different sequences
Number of true positive hits 55 in 55 different sequences
Number of 'unknown' hits 0
Number of false positive hits 9 in 9 different sequences
Number of false negative sequences 4
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 85.94 %
Recall (true positives / (true positives + false negatives)) 93.22 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
55 sequences

CAS1A_XENLA (P55865    ), CAS1B_XENLA (P55867    ), CASP1_CANLF (Q9MZV7    ), 
CASP1_DROME (O02002    ), CASP1_FELCA (Q9MZV6    ), CASP1_HORSE (Q9TV13    ), 
CASP1_HUMAN (P29466    ), CASP1_MOUSE (P29452    ), CASP1_PIG   (Q9N2I1    ), 
CASP1_RAT   (P43527    ), CASP1_SPOFR (P89116    ), CASP2_CHICK (Q98943    ), 
CASP2_HUMAN (P42575    ), CASP2_MOUSE (P29594    ), CASP2_RAT   (P55215    ), 
CASP3_BOVIN (Q08DY9    ), CASP3_CANLF (Q8MKI5    ), CASP3_FELCA (Q8MJU1    ), 
CASP3_HUMAN (P42574    ), CASP3_MACFA (Q2PFV2    ), CASP3_MESAU (Q60431    ), 
CASP3_MOUSE (P70677    ), CASP3_PANTR (Q5IS54    ), CASP3_PIG   (Q95ND5    ), 
CASP3_RABIT (Q8MJC3    ), CASP3_RAT   (P55213    ), CASP3_SAIBB (Q5IS99    ), 
CASP3_XENLA (P55866    ), CASP4_BOVIN (Q5E9C1    ), CASP4_HUMAN (P49662    ), 
CASP4_MOUSE (P70343    ), CASP5_HUMAN (P51878    ), CASP6_BOVIN (Q3T0P5    ), 
CASP6_HUMAN (P55212    ), CASP6_MOUSE (O08738    ), CASP6_RAT   (O35397    ), 
CASP7_HUMAN (P55210    ), CASP7_MESAU (P55214    ), CASP7_MOUSE (P97864    ), 
CASP8_HUMAN (Q14790    ), CASP8_MOUSE (O89110    ), CASP8_RAT   (Q9JHX4    ), 
CASP9_HUMAN (P55211    ), CASP9_MOUSE (Q8C3Q9    ), CASPA_HUMAN (Q92851    ), 
CASPC_CANLF (Q075B4    ), CASPC_MACMU (Q153Z0    ), CASPC_MOUSE (O08736    ), 
CASPC_RAT   (Q920D5    ), CASPD_BOVIN (O75601    ), CED3_CAEEL  (P42573    ), 
CED3_CAERE  (P45436    ), CSP1_CAEEL  (G5EBM1    ), CSP2_CAEEL  (Q9TZP5    ), 
DRICE_DROME (O01382    )
» more

UniProtKB/Swiss-Prot
False negative sequences
4 sequences

CASP8_DROME (Q8IRY7    ), CASPE_HUMAN (P31944    ), CASPE_MOUSE (O89094    ), 
DRONC_DROME (Q9XYF4    )
» more

UniProtKB/Swiss-Prot
False positive sequences
9 sequences

ACCC_ALLVD  (O52058    ), CESAA_ARATH (Q9SKJ5    ), FENR_STAS1  (Q49ZU9    ), 
PARP2_HUMAN (Q9UGN5    ), PARP2_MOUSE (O88554    ), RN133_MACFA (Q95K04    ), 
RPOD_BUCAP  (P32001    ), SUGPH_MYCTU (Q6MWZ7    ), TDRD5_DANRE (Q1L981    )
» more

PDB
[Detailed view]
221 PDB

1BMQ; 1CP3; 1F1J; 1F9E; 1GFW; 1GQF; 1I3O; 1I4E; 1I4O; 1I51; 1IBC; 1ICE; 1JXQ; 1K86; 1K88; 1KMC; 1M72; 1NME; 1NMQ; 1NMS; 1NW9; 1PAU; 1PYO; 1QDU; 1QTN; 1QX3; 1RE1; 1RHJ; 1RHK; 1RHM; 1RHQ; 1RHR; 1RHU; 1RWK; 1RWM; 1RWN; 1RWO; 1RWP; 1RWV; 1RWW; 1RWX; 1SC1; 1SC3; 1SC4; 1SHJ; 1SHL; 2AR9; 2C1E; 2C2K; 2C2M; 2C2O; 2C2Z; 2CDR; 2CJX; 2CJY; 2CNK; 2CNL; 2CNN; 2CNO; 2DKO; 2FQQ; 2FUN; 2H48; 2H4W; 2H4Y; 2H51; 2H54; 2H5I; 2H5J; 2H65; 2HBQ; 2HBR; 2HBY; 2HBZ; 2J30; 2J31; 2J32; 2J33; 2K7Z; 2P2C; 2QL5; 2QL7; 2QL9; 2QLB; 2QLF; 2QLJ; 2WDP; 2XYG; 2XYH; 2XYP; 2XZD; 2XZT; 2Y0B; 2Y1L; 3D6F; 3D6H; 3D6M; 3DEH; 3DEI; 3DEJ; 3DEK; 3E4C; 3EDQ; 3EDR; 3GJQ; 3GJR; 3GJS; 3GJT; 3H0E; 3H11; 3H1P; 3IBC; 3IBF; 3ITN; 3K7E; 3KJF; 3KJN; 3KJQ; 3NKF; 3NR2; 3NS7; 3OD5; 3P45; 3P4U; 3PCX; 3PD0; 3PD1; 3QNW; 3R5J; 3R5K; 3R6G; 3R6L; 3R7B; 3R7N; 3R7S; 3RJM; 3S70; 3S8E; 3SIP; 3SIR; 3V3K; 3V6L; 3V6M; 4DCJ; 4DCO; 4DCP; 4EHA; 4EHD; 4EHF; 4EHH; 4EHK; 4EHL; 4EHN; 4EJF; 4FDL; 4FEA; 4FXO; 4HQ0; 4HQR; 4HVA; 4JB8; 4JJ7; 4JJ8; 4JJE; 4JQY; 4JQZ; 4JR0; 4JR1; 4JR2; 4LSZ; 4M9R; 4N5D; 4N6G; 4N7J; 4N7M; 4NBK; 4NBL; 4NBN; 4PRY; 4PRZ; 4PS0; 4PS1; 4QTX; 4QTY; 4QU0; 4QU5; 4QU8; 4QU9; 4QUA; 4QUB; 4QUD; 4QUE; 4QUG; 4QUH; 4QUI; 4QUJ; 4QUL; 4ZVO; 4ZVP; 4ZVQ; 4ZVR; 4ZVS; 4ZVT; 4ZVU; 5I9B; 5I9T; 5IAB; 5IAE; 5IAG; 5IAJ; 5IAK; 5IAN; 5IAR; 5IAS; 5IBC; 5IBP; 5IBR; 5IC4; 5IC6; 5K20; 5V6U
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission