Entry: PS01121

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General information about the entry

Entry name [info] CASPASE_HIS
Accession [info] PS01121
Entry type [info] PATTERN
Date [info] NOV-1995 (CREATED); DEC-2004 (DATA UPDATE); SEP-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00864

Name and characterization of the entry

Description [info] Caspase family histidine active site.
Pattern [info]
H-x(2,4)-[SC]-x(2)-{A}-x-[LIVMF](2)-[ST]-H-G.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_10 which contains 546'790 sequence entries.


Total number of hits 60 in 60 different sequences
Number of true positive hits 52 in 52 different sequences
Number of 'unknown' hits
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 4
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 86.67 %
Recall (true positives / (true positives + false negatives)) 92.86 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
52 sequences

CAS1A_XENLA (P55865), CAS1B_XENLA (P55867), CASP1_CANFA (Q9MZV7), 
CASP1_DROME (O02002), CASP1_FELCA (Q9MZV6), CASP1_HORSE (Q9TV13), 
CASP1_HUMAN (P29466), CASP1_MOUSE (P29452), CASP1_PIG   (Q9N2I1), 
CASP1_RAT   (P43527), CASP1_SPOFR (P89116), CASP2_CHICK (Q98943), 
CASP2_HUMAN (P42575), CASP2_MOUSE (P29594), CASP2_RAT   (P55215), 
CASP3_BOVIN (Q08DY9), CASP3_CANFA (Q8MKI5), CASP3_FELCA (Q8MJU1), 
CASP3_HUMAN (P42574), CASP3_MACFA (Q2PFV2), CASP3_MESAU (Q60431), 
CASP3_MOUSE (P70677), CASP3_PANTR (Q5IS54), CASP3_PIG   (Q95ND5), 
CASP3_RABIT (Q8MJC3), CASP3_RAT   (P55213), CASP3_SAIBB (Q5IS99), 
CASP3_XENLA (P55866), CASP4_BOVIN (Q5E9C1), CASP4_HUMAN (P49662), 
CASP4_MOUSE (P70343), CASP5_HUMAN (P51878), CASP6_BOVIN (Q3T0P5), 
CASP6_HUMAN (P55212), CASP6_MOUSE (O08738), CASP6_RAT   (O35397), 
CASP7_HUMAN (P55210), CASP7_MESAU (P55214), CASP7_MOUSE (P97864), 
CASP8_HUMAN (Q14790), CASP8_MOUSE (O89110), CASP9_HUMAN (P55211), 
CASP9_MOUSE (Q8C3Q9), CASPA_HUMAN (Q92851), CASPC_CANFA (Q075B4), 
CASPC_MACMU (Q153Z0), CASPC_MOUSE (O08736), CASPC_RAT   (Q920D5), 
CASPD_BOVIN (O75601), CED3_CAEEL  (P42573), CED3_CAERE  (P45436), 
ICE_DROME   (O01382)
» More

UniProtKB/Swiss-Prot
False negative sequences
4 sequences

CASP8_DROME (Q8IRY7), CASPE_HUMAN (P31944), CASPE_MOUSE (O89094), 
ICENC_DROME (Q9XYF4)
» More

UniProtKB/Swiss-Prot
False positive sequences
8 sequences

ACCC_ALLVD  (O52058), CESAA_ARATH (Q9SKJ5), FENR_STAS1  (Q49ZU9), 
PARP2_HUMAN (Q9UGN5), PARP2_MOUSE (O88554), RN133_MACFA (Q95K04), 
RPOD_BUCAP  (P32001), TDRD5_DANRE (Q1L981)
» More

PDB
[Detailed view]
178 PDB

1BMQ; 1CP3; 1F1J; 1F9E; 1GFW; 1GQF; 1I3O; 1I4E; 1I4O; 1I51; 1IBC; 1ICE; 1JXQ; 1K86; 1K88; 1KMC; 1M72; 1NME; 1NMQ; 1NMS; 1NW9; 1PAU; 1PYO; 1QDU; 1QTN; 1QX3; 1RE1; 1RHJ; 1RHK; 1RHM; 1RHQ; 1RHR; 1RHU; 1RWK; 1RWM; 1RWN; 1RWO; 1RWP; 1RWV; 1RWW; 1RWX; 1SC1; 1SC3; 1SC4; 1SHJ; 1SHL; 2AR9; 2C1E; 2C2K; 2C2M; 2C2O; 2C2Z; 2CDR; 2CJX; 2CJY; 2CNK; 2CNL; 2CNN; 2CNO; 2DKO; 2FQQ; 2FUN; 2H48; 2H4W; 2H4Y; 2H51; 2H54; 2H5I; 2H5J; 2H65; 2HBQ; 2HBR; 2HBY; 2HBZ; 2J30; 2J31; 2J32; 2J33; 2K7Z; 2P2C; 2QL5; 2QL7; 2QL9; 2QLB; 2QLF; 2QLJ; 2WDP; 2XYG; 2XYH; 2XYP; 2XZD; 2XZT; 2Y0B; 2Y1L; 3D6F; 3D6H; 3D6M; 3DEH; 3DEI; 3DEJ; 3DEK; 3E4C; 3EDQ; 3EDR; 3GJQ; 3GJR; 3GJS; 3GJT; 3H0E; 3H11; 3H1P; 3IBC; 3IBF; 3ITN; 3K7E; 3KJF; 3KJN; 3KJQ; 3NKF; 3NR2; 3NS7; 3OD5; 3P45; 3P4U; 3PCX; 3PD0; 3PD1; 3QNW; 3R5J; 3R5K; 3R6G; 3R6L; 3R7B; 3R7N; 3R7S; 3RJM; 3S70; 3S8E; 3SIP; 3SIR; 3V3K; 3V6L; 3V6M; 4DCJ; 4DCO; 4DCP; 4EHA; 4EHD; 4EHF; 4EHH; 4EHK; 4EHL; 4EHN; 4EJF; 4FDL; 4FEA; 4FXO; 4HQ0; 4HQR; 4HVA; 4JB8; 4JJ7; 4JJ8; 4JJE; 4JQY; 4JQZ; 4JR0; 4JR1; 4JR2; 4LSZ; 4M9R; 4N5D; 4N6G; 4N7J; 4N7M; 4NBK; 4NBL; 4NBN
» More

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