Entry: PS01121

General information about the entry
Entry name CASPASE_HIS
Accession number PS01121
Entry type PATTERN
Date NOV-1995 (CREATED); DEC-2004 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00864
Name and characterization of the entry
DescriptionCaspase family histidine active site.
Pattern H-x(2,4)-[SC]-x(2)-{A}-x-[LIVMF](2)-[ST]-H-G.
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 60 hits in 60 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 52 hits in 52 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 8 hits in 8 different sequences
  • Number of known missed hits: 4
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0
  • Precision (true hits / (true hits + false positives)): 86.67 %
  • Recall (true hits / (true hits + false negatives)): 92.86 %
Comments
  • Taxonomic range: Eukaryotes
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • `Interesting' site in the pattern: 9,active_site
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
CAS1A_XENLA (P55865), CAS1B_XENLA (P55867), CASP1_CANFA (Q9MZV7), 
CASP1_DROME (O02002), CASP1_FELCA (Q9MZV6), CASP1_HORSE (Q9TV13), 
CASP1_HUMAN (P29466), CASP1_MOUSE (P29452), CASP1_PIG   (Q9N2I1), 
CASP1_RAT   (P43527), CASP1_SPOFR (P89116), CASP2_CHICK (Q98943), 
CASP2_HUMAN (P42575), CASP2_MOUSE (P29594), CASP2_RAT   (P55215), 
CASP3_BOVIN (Q08DY9), CASP3_CANFA (Q8MKI5), CASP3_FELCA (Q8MJU1), 
CASP3_HUMAN (P42574), CASP3_MACFA (Q2PFV2), CASP3_MESAU (Q60431), 
CASP3_MOUSE (P70677), CASP3_PANTR (Q5IS54), CASP3_PIG   (Q95ND5), 
CASP3_RABIT (Q8MJC3), CASP3_RAT   (P55213), CASP3_SAIBB (Q5IS99), 
CASP3_XENLA (P55866), CASP4_BOVIN (Q5E9C1), CASP4_HUMAN (P49662), 
CASP4_MOUSE (P70343), CASP5_HUMAN (P51878), CASP6_BOVIN (Q3T0P5), 
CASP6_HUMAN (P55212), CASP6_MOUSE (O08738), CASP6_RAT   (O35397), 
CASP7_HUMAN (P55210), CASP7_MESAU (P55214), CASP7_MOUSE (P97864), 
CASP8_HUMAN (Q14790), CASP8_MOUSE (O89110), CASP9_HUMAN (P55211), 
CASP9_MOUSE (Q8C3Q9), CASPA_HUMAN (Q92851), CASPC_CANFA (Q075B4), 
CASPC_MACMU (Q153Z0), CASPC_MOUSE (O08736), CASPC_RAT   (Q920D5), 
CASPD_BOVIN (O75601), CED3_CAEEL  (P42573), CED3_CAERE  (P45436), 
ICE_DROME   (O01382)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
CASP8_DROME (Q8IRY7), CASPE_HUMAN (P31944), CASPE_MOUSE (O89094), 
ICENC_DROME (Q9XYF4)
False positive hits (sequences which do not belong to the set under consideration):
ACCC_ALLVD  (O52058), CESAA_ARATH (Q9SKJ5), FENR_STAS1  (Q49ZU9), 
PARP2_HUMAN (Q9UGN5), PARP2_MOUSE (O88554), RN133_MACFA (Q95K04), 
RPOD_BUCAP  (P32001), TDRD5_DANRE (Q1L981)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]
1BMQ; 1CP3; 1F1J; 1F9E; 1GFW; 1GQF; 1I3O; 1I4E; 1I4O; 1I51; 1IBC; 1ICE; 1JXQ; 1K86; 1K88; 1KMC; 1M72; 1MI9; 1MIA; 1NME; 1NMQ; 1NMS; 1NW9; 1PAU; 1PYO; 1QDU; 1QTN; 1QX3; 1RE1; 1RHJ; 1RHK; 1RHM; 1RHQ; 1RHR; 1RHU; 1RWK; 1RWM; 1RWN; 1RWO; 1RWP; 1RWV; 1RWW; 1RWX; 1SC1; 1SC3; 1SC4; 1SHJ; 1SHL; 2AR9; 2C1E; 2C2K; 2C2M; 2C2O; 2C2Z; 2CDR; 2CJX; 2CJY; 2CNK; 2CNL; 2CNN; 2CNO; 2DKO; 2FQQ; 2FUN; 2H48; 2H4W; 2H4Y; 2H51; 2H54; 2H5I; 2H5J; 2H65; 2HBQ; 2HBR; 2HBY; 2HBZ; 2J30; 2J31; 2J32; 2J33; 2K7Z; 2P2C; 2QL5; 2QL7; 2QL9; 2QLB; 2QLF; 2QLJ; 2WDP; 2XYG; 2XYH; 2XYP; 2XZD; 2XZT; 2Y0B; 2Y1L; 3D6F; 3D6H; 3D6M; 3DEH; 3DEI; 3DEJ; 3DEK; 3E4C; 3EDQ; 3EDR; 3GJQ; 3GJR; 3GJS; 3GJT; 3H0E; 3H11; 3H1P; 3IBC; 3IBF; 3ITN; 3K7E; 3KJF; 3KJN; 3KJQ; 3NKF; 3NR2; 3NS7; 3OD5; 3P45; 3P4U; 3PCX; 3PD0; 3PD1; 3QNW; 3R5J; 3R5K; 3R6G; 3R6L; 3R7B; 3R7N; 3R7S; 3RJM; 3S70; 3S8E; 3SIP; 3SIR; 3V3K; 3V6L; 3V6M; 4DCJ; 4DCO; 4DCP; 4EHA; 4EHD; 4EHF; 4EHH; 4EHK; 4EHL; 4EHN; 4EJF; 4FDL; 4FEA; 4FXO;

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