To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Entry: PS50035

General information about the entry

Entry name [info] PLD
Accession [info] PS50035
Entry type [info] MATRIX
Date [info] 01-APR-2002 CREATED; 10-MAY-2017 DATA UPDATE; 22-NOV-2017 INFO UPDATE.
PROSITE Doc. [info] PDOC50035
Associated ProRule [info] PRU00153

Name and characterization of the entry

Description [info] Phospholipase D phosphodiesterase active site profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=28;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=26;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-1.4560000; R2=0.0316000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=975.8386230; R2=0.5719298; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=316; H_SCORE=1157; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=252; H_SCORE=1120; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MM=1; MI=-105; MD=-105; IM=-105; DM=-105; M0=-10;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='Y'; M= -8, -8,-23, -8,-10, -4, -9, -9,-10, -9, -8, -6, -7,-17,-10, -9, -5, -3, -8,-16,  2,-11;
/M:         M= -8,  0,-24, -1, -5, -9, -9, -7,-14, -6, -9, -6,  0,-16, -6, -4, -5, -5,-13,-22, -7, -6;
/M:         M= -8,-10,-28,-11,-12, -9, -2,-10,-16, -6,-13, -9, -6,-16,-10, -2, -9,-11,-14, -6, -2,-12;
/M: SY='V'; M= -3,-19,-21,-22,-15, -3,-22,-17,  3, -7,  1,  1,-15,-20,-12, -3, -9, -2,  6,-14, -2,-15;
/M: SY='H'; M=-12, -1,-23, -8, -7, -7,-19,  9, -1,-11,  1,  6,  5,-22, -2, -8,-10, -8, -8,-24,  1, -6;
/M: SY='H'; M=-19,  5,-29,  3,  0,-20,-17, 89,-29, -9,-21, -3, 16,-20,  9,  0, -7,-17,-30,-31, 15,  0;
/M: SY='S'; M=  0,  2,-19, -1,  1,-18,-12, -3,-17, -4,-15,-10,  3,-12,  2, -2,  6,  5,-13,-28,-12,  1;
/M: SY='K'; M=-10,  0,-30,  0, 10,-30,-20,-10,-30, 49,-30,-10,  0,-10, 10, 32,-10,-10,-20,-20,-10, 10;
/M: SY='L'; M= -7,-23,-21,-28,-22, 10,-20,-18, 13,-23, 15,  9,-18,-24,-20,-19,-14, -4,  9,-15,  4,-22;
/M: SY='M'; M= -7,-26,-20,-31,-24, 15,-27,-15, 17,-21, 18, 19,-24,-26,-19,-18,-19, -8, 14, -8,  9,-21;
/M: SY='I'; M= -4,-28,-21,-32,-27, -1,-29,-27, 30,-24, 15, 13,-23,-24,-22,-23,-15, -5, 29,-19, -5,-26;
/M: SY='V'; M= -4,-25,-17,-29,-24,  7,-29,-25, 23,-22,  9,  8,-20,-23,-23,-21, -8,  1, 27,-22, -3,-25;
/M: SY='D'; M=-18, 45,-29, 64, 23,-39,-11,  0,-39,  1,-29,-29, 18, -9,  2, -9,  1, -9,-29,-39,-20, 13;
/M: SY='D'; M=-10, 23,-27, 28,  8,-31,  3, -1,-31, -1,-27,-21, 17,-14,  2, -4,  3, -8,-27,-33,-19,  4;
/M: SY='E'; M= -3,  0,-23,  1, 11,-20,-16, -6,-20,  8,-17,-11, -1,-11,  3,  5,  0, -1,-14,-25,-12,  6;
/I:         I=-6; MI=0; MD=-21; IM=0; DM=-21;
/M: SY='Y'; M= -7,-14,-19,-18,-13,  4,-22, -4,  5,-13,  3,  2,-12,-19, -9,-11, -8,  0,  3, -7, 11,-13; D=-4;
/I:         DM=-21;
/M: SY='A'; M= 15,-16,-12,-21,-17, -8,-12,-21,  3,-16, -2, -2,-13,-18,-16,-18,  4,  4, 12,-25,-12,-17;
/M: SY='Y'; M=-15,-21,-23,-25,-19, 21,-29,  6,  4,-20,  7,  4,-16,-26,-16,-15,-17,-10, -2, -2, 27,-19;
/M: SY='I'; M= -6,-27,-20,-31,-26,  2,-32,-25, 31,-24, 18, 13,-23,-25,-22,-22,-15, -3, 29,-22, -1,-26;
/M: SY='G'; M=  2, -8,-24,-10,-16,-25, 46,-18,-31,-17,-26,-16,  0,-17,-15,-17,  7, -6,-22,-24,-25,-16;
/M: SY='S'; M=  5, -3,-17, -6, -9,-21, 17,-15,-24,-12,-26,-17,  5,-12, -9,-12, 20, 10,-14,-31,-21, -9;
/M: SY='A'; M= 16,-12,-12,-19,-13, -7,-11,-13, -5,-13, -5, -4, -8,-17,-12,-15,  2, -1,  0,-22,-10,-13;
/M: SY='N'; M=-11, 40,-22, 29,  4,-24, -2,  7,-24,  0,-30,-22, 50,-18,  0, -2,  9, -1,-29,-40,-20,  2;
/M: SY='L'; M=-12,-30,-26,-34,-25, 17,-27,-19, 14,-25, 21, 13,-26,-27,-21,-20,-26,-13,  5, 12, 12,-22;
/M: SY='B'; M= -6, 14, -9, 14, -2,-20, -6, -8,-22, -9,-20,-16, 10,-17, -7,-12,  4, -1,-17,-31,-15, -5;
/M: SY='D'; M=-10, -1,-29,  2, -1,-16, -3, -9,-23, -5,-20,-13, -3, -2, -6,-10, -6, -9,-22,-13,-10, -4;
/M: SY='R'; M= -3, -1,-23, -1,  1,-22, -3,-10,-23,  5,-20,-14,  1,-13, -2, 10,  2, -1,-15,-26,-17, -2;
/M: SY='H'; M= -5, -4,-22, -6, -7, -8,-12, 13,-17, -5,-16,-10,  2,-19, -2,  1,  3, -1,-15,-15, 10, -7;
/I:         E1=0;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2017_11 which contains 556'196 sequence entries.


Total number of hits 411 in 227 different sequences
Number of true positive hits 409 in 225 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 10
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.51 %
Recall (true positives / (true positives + false negatives)) 97.61 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Feature key [info] DOMAIN
Feature description [info] PLD phosphodiesterase
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
225 sequences

CLS1_BACAN  (Q81V75    ), CLS1_BACCR  (Q81I00    ), CLS1_BACSU  (P45860    ), 
CLS1_STAAC  (Q5HGA3    ), CLS1_STAAR  (Q6GH88    ), CLS1_STAEQ  (Q5HPM5    ), 
CLS1_STAES  (Q8CPD8    ), CLS2_BACAN  (Q81TR2    ), CLS2_BACCR  (Q81GK4    ), 
CLS2_STAAC  (Q5HEB2    ), CLS2_STAAR  (Q6GEY7    ), CLS2_STAEQ  (Q5HMD3    ), 
CLS2_STAES  (Q8CNK3    ), CLSA_BACSU  (P71040    ), CLSA_BUCA5  (B8D966    ), 
CLSA_BUCAI  (P57361    ), CLSA_BUCAP  (Q8K9P9    ), CLSA_BUCAT  (B8D7H0    ), 
CLSA_BUCBP  (Q89AL5    ), CLSA_CITK8  (A8AG50    ), CLSA_CROS8  (A7MNA4    ), 
CLSA_ECO24  (A7ZL20    ), CLSA_ECO27  (B7UQD9    ), CLSA_ECO45  (B7ML01    ), 
CLSA_ECO55  (B7LHJ4    ), CLSA_ECO57  (Q8XCC6    ), CLSA_ECO5E  (B5YYF4    ), 
CLSA_ECO7I  (B7NVL8    ), CLSA_ECO81  (B7MU36    ), CLSA_ECO8A  (B7LY04    ), 
CLSA_ECOBW  (C4ZTU1    ), CLSA_ECODH  (B1XAT9    ), CLSA_ECOHS  (A7ZZI5    ), 
CLSA_ECOK1  (A1AAH3    ), CLSA_ECOL5  (Q0TIC2    ), CLSA_ECOL6  (P0A6H9    ), 
CLSA_ECOLC  (B1ITK7    ), CLSA_ECOLI  (P0A6H8    ), CLSA_ECOLU  (B7N460    ), 
CLSA_ECOSE  (B6I9W2    ), CLSA_ECOSM  (B1LH51    ), CLSA_ECOUT  (Q1RCI7    ), 
CLSA_EDWI9  (C5BDA3    ), CLSA_ENT38  (A4WB84    ), CLSA_ERWT9  (B2VKV4    ), 
CLSA_ESCF3  (B7LS29    ), CLSA_KLEP3  (B5XQA9    ), CLSA_KLEP7  (A6TAJ7    ), 
CLSA_PECAS  (Q6D4S2    ), CLSA_PECCP  (C6DGY3    ), CLSA_PROMH  (B4EWI7    ), 
CLSA_PSEA8  (B7V5T6    ), CLSA_PSEAB  (Q02DW8    ), CLSA_PSEAE  (Q9HTH0    ), 
CLSA_PSEE4  (Q1I2L0    ), CLSA_PSEF5  (Q4K3D9    ), CLSA_PSEFS  (C3K1C4    ), 
CLSA_PSEP1  (A5WB80    ), CLSA_PSEPG  (B0KR91    ), CLSA_PSEPK  (Q88C19    ), 
CLSA_PSEPU  (P31048    ), CLSA_PSEPW  (B1JFN5    ), CLSA_PSESM  (Q87TY7    ), 
CLSA_PSEU2  (Q4ZL66    ), CLSA_SALA4  (B5F4L0    ), CLSA_SALAR  (A9MPD5    ), 
CLSA_SALCH  (Q57NS0    ), CLSA_SALDC  (B5FU52    ), CLSA_SALEP  (B5R3N1    ), 
CLSA_SALG2  (B5R6L2    ), CLSA_SALHS  (B4TJM2    ), CLSA_SALNS  (B4SUC9    ), 
CLSA_SALPA  (Q5PCS9    ), CLSA_SALPB  (A9MWP9    ), CLSA_SALPC  (C0Q393    ), 
CLSA_SALPK  (B5BIA8    ), CLSA_SALSV  (B4TX53    ), CLSA_SALTI  (P63799    ), 
CLSA_SALTY  (P63798    ), CLSA_SERP5  (A8GFA0    ), CLSA_SHIB3  (B2TZZ4    ), 
CLSA_SHIBS  (Q31ZU1    ), CLSA_SHIDS  (Q32GV1    ), CLSA_SHIFL  (Q83RM8    ), 
CLSA_SHISS  (Q3Z0W3    ), CLSA_SODGM  (Q2NT72    ), CLSA_WIGBR  (Q8D2I8    ), 
CLSA_YERE8  (A1JQ40    ), CLSA_YERP3  (A7FI50    ), CLSA_YERPA  (Q1C7R0    ), 
CLSA_YERPB  (B2K3U5    ), CLSA_YERPE  (Q8ZEI2    ), CLSA_YERPG  (A9R8K8    ), 
CLSA_YERPN  (Q1CJ46    ), CLSA_YERPP  (A4TJ85    ), CLSA_YERPS  (Q66AL9    ), 
CLSA_YERPY  (B1JKT9    ), CLSB_BACSU  (P45865    ), CLSB_ECO57  (P0AA85    ), 
CLSB_ECOL6  (Q8FJN9    ), CLSB_ECOLI  (P0AA84    ), CLSB_SALTI  (Q8Z883    ), 
CLSB_SALTY  (Q8ZQP4    ), CLSB_SHIFL  (P59715    ), CLSC_ECOLI  (P75919    ), 
CLS_BACHD   (Q9K8Z4    ), CLS_BACPE   (O66043    ), CLS_CLOP1   (Q0TQG9    ), 
CLS_CLOPE   (P0C2E2    ), CLS_CLOPS   (Q0ST20    ), CLS_GEOKA   (Q5L1S5    ), 
CLS_GEOSW   (C5D794    ), CLS_GEOTN   (A4IL76    ), CLS_LISIN   (Q927Z0    ), 
CLS_LISMC   (C1KYS0    ), CLS_LISMF   (Q71WS5    ), CLS_LISMH   (B8DBK8    ), 
CLS_LISMO   (Q8Y4E3    ), CLS_LISW6   (A0ALI7    ), CLS_OCEIH   (Q8EM16    ), 
CLS_STAAM   (P63800    ), CLS_STAAN   (P63801    ), CLS_STAAS   (Q6G7M2    ), 
CLS_STAAW   (P63802    ), F13_FOWPN   (P36316    ), F13_MCV1    (P26579    ), 
F13_MCV2    (P25392    ), F13_VACCA   (O57179    ), F13_VACCC   (P20638    ), 
F13_VACCI   (P26653    ), F13_VACCP   (P29885    ), F13_VACCW   (P04021    ), 
F13_VAR67   (P33815    ), K4_VACCC    (P20537    ), K4_VACCW    (P18377    ), 
PGPS1_BOVIN (Q2KJ28    ), PGPS1_CHICK (Q5ZHN9    ), PGPS1_CRIGR (Q9Z2Z7    ), 
PGPS1_DICDI (Q7KWX2    ), PGPS1_HUMAN (Q32NB8    ), PGPS1_MOUSE (Q8BHF7    ), 
PGPS1_PONAB (Q5R8K7    ), PGPS1_SACPS (P79001    ), PGPS1_YEAST (P25578    ), 
PLD1_CRIGR  (O08684    ), PLD1_HUMAN  (Q13393    ), PLD1_MOUSE  (Q9Z280    ), 
PLD1_RAT    (P70496    ), PLD1_SCHPO  (Q09706    ), PLD2_BOVIN  (Q0V8L6    ), 
PLD2_HUMAN  (O14939    ), PLD2_MOUSE  (P97813    ), PLD2_RAT    (P70498    ), 
PLD3_BOVIN  (Q2KJJ8    ), PLD3_HUMAN  (Q8IV08    ), PLD3_MACFA  (Q4R583    ), 
PLD3_MOUSE  (O35405    ), PLD3_PONAB  (Q5R4Y7    ), PLD3_RAT    (Q5FVH2    ), 
PLD3_XENLA  (Q6PB03    ), PLD3_XENTR  (Q640B3    ), PLD4_HUMAN  (Q96BZ4    ), 
PLD4_MOUSE  (Q8BG07    ), PLD5_MOUSE  (Q3UNN8    ), PLD6_BOVIN  (E1BE10    ), 
PLD6_CANLF  (E2RD63    ), PLD6_CHLRE  (A8IW99    ), PLD6_HUMAN  (Q8N2A8    ), 
PLD6_MOUSE  (Q5SWZ9    ), PLD6_XENLA  (A1L1C2    ), PLD6_XENTR  (Q28DT3    ), 
PLDA1_ARATH (Q38882    ), PLDA1_BRAOC (O82549    ), PLDA1_CARPA (P86387    ), 
PLDA1_CYNCA (Q70EW5    ), PLDA1_MAIZE (Q43270    ), PLDA1_ORYSJ (Q43007    ), 
PLDA1_PIMBR (O04883    ), PLDA1_RICCO (Q41142    ), PLDA1_TOBAC (P93400    ), 
PLDA1_VIGUN (O04865    ), PLDA2_ARATH (Q9SSQ9    ), PLDA2_BRAOC (P55939    ), 
PLDA2_ORYSJ (P93844    ), PLDA3_ARATH (P58766    ), PLDA4_ARATH (Q9C888    ), 
PLDA_DICDI  (Q54UK0    ), PLDB1_ARATH (P93733    ), PLDB2_ARATH (O23078    ), 
PLDB_DICDI  (Q54WR4    ), PLDC_DICDI  (Q54Z25    ), PLDD1_ARATH (Q9C5Y0    ), 
PLDG1_ARATH (Q9T053    ), PLDG2_ARATH (Q9T051    ), PLDG3_ARATH (Q9T052    ), 
PLDL_CAEEL  (O17405    ), PLDY_DICDI  (Q54K50    ), PLDZ1_ARATH (Q9LRZ5    ), 
PLDZ2_ARATH (Q9M9W8    ), PLDZ_DICDI  (Q54SA1    ), PLD_PHYIN   (Q5BMR2    ), 
PLD_RICBR   (Q1RK58    ), PLD_RICCN   (Q92G53    ), PLD_RICFE   (Q4UJZ1    ), 
PLD_RICPR   (Q9ZCD8    ), PLD_RICTY   (Q68VT0    ), PLD_STRAT   (Q53728    ), 
PPK1_ECO57  (P0A7B2    ), PPK1_ECOL6  (Q8FF70    ), PPK1_ECOLI  (P0A7B1    ), 
PPK1_KLEPN  (Q07411    ), PPK1_SALTI  (Q8Z4R0    ), PPK1_SALTY  (O86090    ), 
PPK1_VIBCH  (Q9KU07    ), PPK1_VIBPA  (Q87S51    ), PPK1_VIBVU  (Q8DEW2    ), 
PPK1_VIBVY  (Q7MNJ0    ), PPK1_YERPE  (Q8ZCX2    ), PSS_ECOLI   (P23830    ), 
PSS_HAEIN   (P44704    ), SPO14_YEAST (P36126    ), Y190_HELPJ  (Q9ZMP2    ), 
Y190_HELPY  (P56117    ), Y988_STRMU  (P34001    ), YJHR_ECOLI  (P39369    )
» more

UniProtKB/Swiss-Prot
False negative sequences
10 sequences

PGPS1_SCHPO (Q9HDW1    ), PLD5_HUMAN  (Q8N7P1    ), PLD6_DANRE  (A3KNW0    ), 
PPK1_PSEPK  (Q88CG4    ), PPK1_PSESM  (Q87UP6    ), PPK1_STAEQ  (Q5HLE0    ), 
PPK1_STAES  (Q8CR71    ), PPK1_STAHJ  (Q4L8X9    ), PPK1_STAS1  (Q4A040    ), 
ZUC_DROME   (Q9VKD7    )
» more

UniProtKB/Swiss-Prot
False positive sequences
2 sequences

DYHA_CHLRE  (Q39610    ), TYDP1_CAEEL (Q9TXV7    )

		
PDB
[Detailed view]
7 PDB

1XDO; 1XDP; 2ZE4; 2ZE9; 3HSI; 4GGJ; 4GGK

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission