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| Entry: PS50068 |
General information about the entry
| Entry name [info] | LDLRA_2 |
| Accession [info] | PS50068 |
| Entry type [info] | MATRIX |
| Date [info] | 01-NOV-1997 CREATED; 10-MAY-2017 DATA UPDATE; 05-JUL-2017 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00929 |
| Associated ProRule [info] | PRU00124 |
Name and characterization of the entry
| Description [info] | LDL-receptor class A (LDLRA) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=37; /DISJOINT: DEFINITION=PROTECT; N1=4; N2=35; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-1.4750000; R2=0.0125000; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1098.3571777; R2=3.3571429; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=798; H_SCORE=3777; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=638; H_SCORE=3240; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-30; E1=-30; MI=-105; MD=-105; IM=-105; DM=-105; MM=1; M0=-1; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='T'; M= -4, -2,-21, -4, 1,-17,-13, -9,-15, -2,-14, -9, -1, -9, 0, -2, 3, 5,-11,-27,-13, 0; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='S'; M= -4, -1,-25, 0, 2,-22, -8, -6,-20, -2,-20,-13, 0, 1, 1, -4, 3, -2,-17,-28,-16, 0; /I: II=-7; MI=-7; IM=-7; MD=-15; DM=-15; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='P'; M= -1, -5,-21, -3, 3,-22,-10,-12,-18, -4,-19,-13, -5, 11, -2, -8, 1, -3,-16,-27,-18, -1; D=-3; /I: DM=-17; /M: SY='N'; M= -7, 8,-23, 8, 1,-21, 0, -3,-24, -5,-20,-15, 9,-14, -3, -5, 4, -1,-19,-28,-13, -2; /I: DM=-17; /M: SY='E'; M= -9, 0,-27, 3, 19,-22,-15, 3,-22, 4,-17, -9, -1,-10, 16, 2, -2, -8,-22,-21, -9, 17; /M: SY='F'; M=-17,-27,-22,-34,-26, 58,-29,-12, 0,-24, 7, 1,-18,-28,-31,-16,-18,-10, 0, 7, 27,-26; /M: SY='Q'; M= -6, -3,-25, -4, 6,-24,-17, 0,-19, 9,-17, -6, -2,-10, 15, 13, -1, -3,-17,-24,-10, 9; /M: SY='C'; M=-10,-20,119,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-48,-30,-30; /M: SY='S'; M= -2, -1,-24, -1, 0,-22, -3, -7,-22, 0,-20,-13, 0, -6, -2, -1, 2, -4,-17,-26,-15, -2; /M: SY='N'; M= -5, 18,-20, 14, 1,-22, -2, -1,-22, -4,-24,-17, 22,-15, -2, -6, 10, 1,-20,-33,-17, -1; /I: II=-4; MI=-5; IM=-5; MD=-15; DM=-15; I=0,0,-20,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='G'; M= -5, -4,-26, -5, -8,-23, 25, -8,-28, -8,-22,-14, 2,-16, -8, -7, 0,-11,-23,-23,-18, -9; D=-2; /I: DM=-15; /M: SY='R'; M= -8, -5,-24, -6, 4,-19,-18, -2,-16, 8,-14, -6, -2,-14, 8, 13, -1, -2,-13,-24, -8, 5; /M: SY='C'; M=-10,-20,118,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-29,-10,-10,-10,-49,-29,-30; /M: SY='I'; M= -8,-29,-25,-36,-28, 2,-36,-27, 40,-27, 20, 17,-22,-23,-21,-26,-19, -8, 29,-20, 0,-28; /M: SY='P'; M= -3, -4,-28, -1, 2,-24,-13, -9,-19, -5,-23,-15, -4, 27, -3,-10, 2, -3,-21,-29,-19, -3; D=-4; /I: II=-7; MI=-15; IM=-15; MD=-15; DM=-15; I=0,0,-20,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='R'; M= -5, -8,-24,-10, -2,-15,-14, -9,-11, -1, -9, -3, -5,-11, -1, 1, -5, -6,-10,-21,-10, -3; /M: SY='S'; M= -3, 0,-21, 0, 2,-17, -9, -3,-18, -3,-16,-11, 2,-14, 0, -2, 6, 0,-14,-25,-10, 1; /M: SY='W'; M=-11,-17,-30,-19,-10, 0,-20,-12,-13, -3, -8, -7,-15,-22, -5, -2,-17,-13,-15, 25, 8, -7; /M: SY='V'; M= -8,-19,-22,-21,-14, -6,-24,-14, 2, -4, 2, 3,-16,-22, -9, 3,-13, -6, 7,-16, -5,-12; /M: SY='C'; M=-10,-20,115,-29,-29,-20,-30,-29,-29,-29,-20,-19,-20,-39,-28,-29,-10,-10,-10,-49,-29,-29; /M: SY='D'; M=-17, 46,-27, 56, 14,-34, -8, 2,-34, 0,-29,-27, 29,-13, 0, -8, 2, -7,-29,-40,-20, 7; /M: SY='G'; M= -3, -5,-28, -6,-13,-25, 42,-11,-33,-13,-25,-16, 3,-19,-12,-11, -1,-15,-26,-22,-22,-13; /M: SY='D'; M= -8, 1,-24, 3, 2,-15,-18, -3,-12, -2,-12, -8, -2,-16, -1, -4, -4, -5, -8,-25, -6, 0; /I: II=-7; MI=-15; IM=-15; MD=-15; DM=-15; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='B'; M= -7, 8,-23, 7, 1,-18,-14, -6,-17, -3,-18,-13, 8, -5, -3, -5, -1, -4,-15,-27,-13, -2; /M: SY='D'; M=-18, 44,-29, 59, 18,-37, -9, 2,-37, 0,-28,-27, 21,-11, 1, -8, 0, -9,-29,-39,-19, 10; /M: SY='C'; M=-10,-20,119,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-48,-30,-30; /M: SY='G'; M= -3, -6,-26, -4, -1,-22, 3, -9,-21, -5,-18,-12, -4, -2, -4, -6, 0, -7,-18,-25,-16, -4; /M: SY='D'; M=-16, 39,-28, 52, 13,-33, -6, 0,-35, -2,-28,-26, 20,-11, -1, -9, 1, -8,-28,-36,-17, 6; /M: SY='G'; M= -3, -4,-26, -6,-11,-24, 33,-10,-30,-11,-24,-15, 4,-18,-10,-11, 0,-13,-25,-19,-19,-11; /M: SY='S'; M= 5, 2,-15, 2, 5,-20, -4, -8,-20, -7,-24,-16, 7,-11, 1, -9, 25, 11,-13,-35,-17, 3; /M: SY='D'; M=-18, 42,-29, 60, 18,-36,-10, 0,-37, -1,-27,-27, 16,-11, -1,-10, -1, -9,-27,-36,-18, 8; /M: SY='E'; M=-10, 11,-29, 20, 53,-29,-18, -1,-29, 8,-20,-20, 1, -2, 17, -1, 1, -9,-28,-30,-19, 35; /I: II=-7; MI=-15; IM=-15; MD=-15; DM=-15; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='E'; M= -1, -3,-22, -3, 6,-19,-16, -6,-14, 2,-11, -7, -3,-11, 3, 0, -2, -4,-12,-25,-11, 4; D=-3; /I: DM=-13; /M: SY='N'; M= -8, 8,-23, 6, -1,-20, -2, -2,-19, -5,-17,-12, 10,-15, -2, -5, 0, -6,-18,-28,-12, -3; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='S'; M= -1, -3,-22, -3, 0,-21, -4, -9,-19, -5,-19,-13, -1, -2, -4, -6, 4, -1,-14,-28,-18, -3; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 847 in 160 different sequences |
| Number of true positive hits | 847 in 160 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 8 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 99.06 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | K_Hofmann |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 36 |
| Feature key [info] | DOMAIN |
| Feature description [info] | LDL-receptor class A |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
160 sequences
AEGP_HUMAN (Q6UXC1 ), AEGP_MOUSE (A2AJA7 ), AEGP_RAT (Q63191 ), CD320_BOVIN (A6QNY1 ), CD320_HUMAN (Q9NPF0 ), CD320_MOUSE (Q9Z1P5 ), CD320_RAT (Q5HZW5 ), CFAI_HUMAN (P05156 ), CFAI_MOUSE (Q61129 ), CFAI_PONAB (Q5R5A4 ), CFAI_RAT (Q9WUW3 ), CO6_BOVIN (Q29RU4 ), CO6_HUMAN (P13671 ), CO6_PANTR (P61134 ), CO6_PONPY (P61135 ), CO6_RAT (Q811M5 ), CO7_BOVIN (Q29RQ1 ), CO7_HUMAN (P10643 ), CO7_PIG (Q9TUQ3 ), CO7_PONAB (Q5RAD0 ), CO8A_HUMAN (P07357 ), CO8A_MOUSE (Q8K182 ), CO8A_RABIT (P98136 ), CO8B_HUMAN (P07358 ), CO8B_MOUSE (Q8BH35 ), CO8B_ONCMY (Q90X85 ), CO8B_PAROL (Q9PVW7 ), CO8B_RABIT (P98137 ), CO8B_RAT (P55314 ), CO9_BOVIN (Q3MHN2 ), CO9_HORSE (P48770 ), CO9_HUMAN (P02748 ), CO9_MOUSE (P06683 ), CO9_ONCMY (P06682 ), CO9_RABIT (P48747 ), CO9_RAT (Q62930 ), CO9_TAKRU (P79755 ), CORIN_HUMAN (Q9Y5Q5 ), CORIN_MOUSE (Q9Z319 ), CORIN_RAT (Q80YN4 ), CPROH_CONVC (A0A0F7YYX3), CTX_SEPES (B2DCR8 ), ENTK_BOVIN (P98072 ), ENTK_HUMAN (P98073 ), ENTK_MOUSE (P97435 ), ENTK_PIG (P98074 ), GLBL_LAMSP (P16222 ), GLBL_TYLHE (P18207 ), GLBM_TYLHE (P18208 ), GR101_LYMST (P46023 ), IDD_HUMAN (P98153 ), IDD_MOUSE (P98154 ), LDLR1_XENLA (Q99087 ), LDLR2_XENLA (Q99088 ), LDLR_BOVIN (P01131 ), LDLR_CRIGR (P35950 ), LDLR_HUMAN (P01130 ), LDLR_MOUSE (P35951 ), LDLR_PIG (Q28832 ), LDLR_RABIT (P20063 ), LDLR_RAT (P35952 ), LRAD1_HUMAN (Q5T700 ), LRAD2_HUMAN (Q5SZI1 ), LRAD3_HUMAN (Q86YD5 ), LRAD3_MOUSE (A2AR95 ), LRAD3_XENTR (A4IHY6 ), LRAD4_HUMAN (O15165 ), LRAD4_MOUSE (Q8BWJ4 ), LRP10_HUMAN (Q7Z4F1 ), LRP10_MOUSE (Q7TQH7 ), LRP11_HUMAN (Q86VZ4 ), LRP11_MOUSE (Q8CB67 ), LRP12_HUMAN (Q9Y561 ), LRP12_MACFA (Q9BE74 ), LRP12_MOUSE (Q8BUJ9 ), LRP12_PONAB (Q5R662 ), LRP1B_HUMAN (Q9NZR2 ), LRP1B_MOUSE (Q9JI18 ), LRP1_CHICK (P98157 ), LRP1_HUMAN (Q07954 ), LRP1_MOUSE (Q91ZX7 ), LRP2_HUMAN (P98164 ), LRP2_MOUSE (A2ARV4 ), LRP2_RAT (P98158 ), LRP3_HUMAN (O75074 ), LRP3_RAT (O88204 ), LRP4_HUMAN (O75096 ), LRP4_MOUSE (Q8VI56 ), LRP4_RAT (Q9QYP1 ), LRP5_HUMAN (O75197 ), LRP5_MOUSE (Q91VN0 ), LRP6_HUMAN (O75581 ), LRP6_MOUSE (O88572 ), LRP8_CHICK (Q98931 ), LRP8_HUMAN (Q14114 ), LRP8_MOUSE (Q924X6 ), LRP_CAEEL (Q04833 ), MALR1_HUMAN (Q5VYJ5 ), MALR1_MOUSE (A2AJX4 ), MFRP_HUMAN (Q9BY79 ), MFRP_MOUSE (Q8K480 ), MIG13_CAEEL (G5EF33 ), MLRP1_ACRMI (B3EWZ5 ), MLRP2_ACRMI (B3EWZ6 ), MODSP_DROME (Q9VER6 ), MUA3_CAEEL (P34576 ), NETO1_HUMAN (Q8TDF5 ), NETO1_MOUSE (Q8R4I7 ), NETO2_HUMAN (Q8NC67 ), NETO2_MOUSE (Q8BNJ6 ), NETO2_RAT (C6K2K4 ), NUDEL_DROME (P98159 ), PGBM_HUMAN (P98160 ), PGBM_MOUSE (Q05793 ), PROH4_APIME (P85831 ), PROH4_CAMFO (E2AX35 ), RSVR_COTJA (P98162 ), RXFP1_HUMAN (Q9HBX9 ), RXFP1_MOUSE (Q6R6I7 ), RXFP1_PONAB (Q5R5V8 ), RXFP1_RAT (Q6R6I6 ), RXFP2_CANLF (Q5XM32 ), RXFP2_HUMAN (Q8WXD0 ), RXFP2_MOUSE (Q91ZZ5 ), SCD2_CAEEL (O76411 ), SORL_CHICK (Q98930 ), SORL_HUMAN (Q92673 ), SORL_MOUSE (O88307 ), SORL_RABIT (Q95209 ), SPIT1_HUMAN (O43278 ), SPIT1_MOUSE (Q9R097 ), SSPO_BOVIN (P98167 ), SSPO_CHICK (Q2PC93 ), SSPO_HUMAN (A2VEC9 ), SSPO_MOUSE (Q8CG65 ), SSPO_RAT (Q700K0 ), ST14_BOVIN (Q0IIH7 ), ST14_HUMAN (Q9Y5Y6 ), ST14_MOUSE (P56677 ), TMPS2_HUMAN (O15393 ), TMPS2_MOUSE (Q9JIQ8 ), TMPS3_HUMAN (P57727 ), TMPS3_MOUSE (Q8K1T0 ), TMPS6_HUMAN (Q8IU80 ), TMPS6_MOUSE (Q9DBI0 ), TMPS7_HUMAN (Q7RTY8 ), TMPS7_MOUSE (Q8BIK6 ), TMPS7_RAT (P86091 ), TMPS9_HUMAN (Q7Z410 ), TMPS9_MOUSE (P69525 ), TMPS9_RAT (P69526 ), UNC52_CAEEL (Q06561 ), VGR_SOLIN (Q6X0I2 ), VLDLR_CHICK (P98165 ), VLDLR_HUMAN (P98155 ), VLDLR_MOUSE (P98156 ), VLDLR_RABIT (P35953 ), VLDLR_RAT (P98166 ), YL54_CAEEL (P34434 ), YL_DROME (P98163 )» more
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| UniProtKB/Swiss-Prot False negative sequences |
8 sequences
ALK_HUMAN (Q9UM73 ), ALK_MOUSE (P97793 ), PKD1_HUMAN (P98161 ), PKD1_MOUSE (O08852 ), TMPS4_HUMAN (Q9NRS4 ), TMPS4_MOUSE (Q8VCA5 ), TMPSD_HUMAN (Q9BYE2 ), TMPSD_MOUSE (Q5U405 )» more |
| PDB [Detailed view] |
38 PDB
1AJJ; 1CR8; 1D2J; 1D2L; 1F5Y; 1F8Z; 1J8E; 1JRF; 1K7B; 1LDL; 1LDR; 1N7D; 1V9U; 1XFE; 2FCW; 2FYJ; 2FYL; 2I1P; 2JM4; 2KNX; 2KNY; 2KRI; 2LGP; 2M0P; 2M7P; 2M96; 2XRC; 3A7Q; 3DPR; 3M0C; 3OJY; 3P5C; 3T5O; 4A5W; 4E0S; 4ZRP; 4ZRQ; 5FMW » more |
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