Entry: PS50800

Forthcoming changes to the profile format
General information about the entry

Entry name [info] SAP
Accession [info] PS50800
Entry type [info] MATRIX
Date [info] FEB-2003 (CREATED); OCT-2013 (DATA UPDATE); MAR-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC50800
Associated ProRule [info] PRU00186

Name and characterization of the entry

Description [info] SAP motif profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=35;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=32;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1756; R2=0.01997568; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1182.63636; R2=12.60744; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=316; N_SCORE=8.5; H_SCORE=4549; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=216; N_SCORE=6.5; H_SCORE=3906; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105; M0=-8;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='L'; M=-11,-18,-24,-20, -8,  5,-27,-11,  6, -8, 10,  8,-18,-22,-11, -9,-17, -9,  3,-13,  8,-10;
/M: SY='T'; M=  9, -6,-17,-11, -1,-16,-10,-14, -8, -9, -9, -3, -5,-11, -4,-13,  7, 11, -4,-26,-14, -3;
/M: SY='S'; M= -4,-10,-24, -8, -2,-19, -4, -7,-14,-10,-13, -9, -5, -1, -6,-12,  3, -4,-14,-29,-15, -5;
/M: SY='L'; M= -8,-25,-19,-28,-21,  9,-25,-13, 16,-21, 25, 23,-23,-26,-15,-16,-18, -6, 12,-18,  4,-18;
/M: SY='T'; M= -4, -5, -7,-10, -6,-17,-17,-14,-17,  3,-18,-11, -1,-15, -3,  8, 10, 15, -8,-30,-13, -6;
/M: SY='V'; M= -2,-14,-18,-15,-12, -8,-24,-15,  9,-12,  0,  4,-16,-21, -9,-14, -6,  0, 15,-23, -3,-11;
/M: SY='S'; M=  4, -2,-16, -3,  2,-20, -9, -4,-20, -5,-23,-16,  4, -5,  0, -3, 21, 14,-13,-33,-15,  0;
/M: SY='E'; M= -3,  5,-25,  9, 23,-22,-17, -6,-21,  4,-16,-13, -2, -9, 10, -4, -1, -8,-17,-25,-14, 17;
/M: SY='L'; M=-10,-30,-22,-32,-22,  8,-32,-22, 27,-30, 43, 20,-28,-28,-20,-22,-28,-10, 14,-20,  0,-22;
/M: SY='R'; M=-14, -4,-30, -4,  8,-28,-20,  0,-27, 30,-23, -7,  0,-14, 24, 42, -7,-10,-23,-20,-10, 14;
/M: SY='D'; M= -8, 12,-24, 17,  2,-26, -8, -8,-19, -4,-19,-11,  4,-13,  0, -8,  4, -2,-13,-31,-16,  1;
/M: SY='M'; M= -1,-15,-22,-19, -8, -4,-23,-16,  2, -4,  5,  6,-13,-17, -9, -8,-11, -5,  0,-19, -5, -9;
/M: SY='C'; M= -5,-25, 24,-29,-22, -2,-27,-23,  2,-28, 23,  5,-25,-31,-22,-23,-20, -9,  3,-29,-11,-22;
/M: SY='R'; M= -6, -2,-26,  0, 10,-26, -5, -6,-28, 16,-26,-14,  2,-12,  9, 18,  4, -5,-21,-26,-16,  9;
/M: SY='E'; M=  2, -4,-22, -4,  9,-15,-15, -1,-17,  3,-17,-10, -3,-12,  5, -2,  3, -4,-13,-22, -6,  7;
/M: SY='R'; M= -9,-14,-22,-17, -9, -1,-22, -9, -2, -5,  5,  4,-11,-23, -8,  6,-13, -7,  0,-19, -1,-10;
/M: SY='G'; M=  2, -8,-27, -8,-17,-28, 59,-18,-37,-18,-30,-20,  2,-18,-17,-18,  7,-13,-27,-23,-28,-17;
/M: SY='L'; M=-11,-25,-21,-26,-16,  8,-28,-16, 11,-19, 30, 13,-24,-27,-13, -7,-23, -9,  6,-18,  0,-15;
/M: SY='S'; M= -1, -1,-23,  0,  1,-24, -9, -9,-23, -1,-26,-18,  3, 10, -1,  4, 11,  2,-18,-32,-20, -2;
/M: SY='T'; M=  1, -7, -4,-13,-10,-13,-19,-10,-11, -7,-10, -7, -5,-16, -9, -8,  7, 19, -2,-30,-10,-10;
/M: SY='N'; M= -5, 11,-21,  7,  1,-23, -3,  9,-23, -6,-26,-16, 18, -7,  2, -6, 13,  4,-22,-34,-15,  0;
/M: SY='G'; M=  1, -9,-28, -9,-18,-29, 65,-19,-38,-19,-30,-20,  1,-19,-18,-19,  3,-17,-28,-22,-29,-18;
/M: SY='R'; M= -8, -6,-25, -8, -5,-19,-11, -6,-18,  2,-18,-10, -1,  0, -4,  5, -1,  0,-14,-27,-14, -6;
/M: SY='K'; M=-12, -1,-30,  0, 12,-28,-20, -8,-30, 44,-28,-11,  0,-11, 11, 34, -9,-10,-21,-21,-11, 11;
/M: SY='Q'; M=  1, -7,-25, -9,  2,-26,-16,  5,-18,  6,-17, -5, -5, -6, 16,  8, -3, -8,-16,-23,-10,  7;
/M: SY='E'; M=-12,  0,-25,  3, 12,-14,-21,  3,-12, -3, -6, -7, -2,-16,  0, -1, -8, -8,-11,-25, -5,  5;
/M: SY='L'; M= -9,-29,-20,-31,-22,  7,-30,-20, 23,-27, 42, 23,-28,-28,-19,-20,-27, -9, 15,-21, -1,-21;
/M: SY='I'; M= -8,-20,-11,-24,-13, -8,-30,-19, 15,-19, 11,  8,-18,-22, -7,-17,-13, -5, 10,-25, -7,-12;
/M: SY='D'; M=-11, 11,-25, 15,  8,-26,-19, -8,-19,  6,-18,-12,  2,-12,  4,  2, -1,  1,-13,-29,-13,  5;
/M: SY='R'; M=-12,-13,-15,-15, -6,-17,-21, -8,-20, 16,-12, -7, -7,-22,  0, 40,-10, -9,-11,-23,-11, -6;
/M: SY='L'; M= -6,-16,-14,-19,-16, -4,-26, -2,  7,-21, 12,  6,-15,-24,-13,-19,-16,-10,  2,-21,  4,-17;
/M: SY='R'; M= -2, -5,-21,-10, -6,-14,-17,-11,-10,  6, -5, -4,  0,-19, -5,  9, -6, -2, -6,-24,-11, -6;
/M: SY='E'; M=-10,  8,-27, 10, 16,-29, -8, 12,-29, 10,-25,-13,  9,-11, 13,  4,  1, -9,-26,-28,-12, 14;
/M: SY='Y'; M= -4,-20,-26,-23,-18,  5,-15,  3, -7,-18,  0, -2,-17,-24,-14,-15,-16,-13, -7, 11, 16,-17;
/M: SY='L'; M= -8,-16,-21,-18, -6, -1,-27,-17,  7,-12, 10,  7,-16,-18,-11,-12,-11,  1,  7,-23, -5, -9;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_04 which contains 544'996 sequence entries.


Total number of hits 117 in 114 different sequences
Number of true positive hits 117 in 114 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 16
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 87.97 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 2
Feature key [info] DOMAIN
Feature description [info] SAP
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
114 sequences

049L_FRG3G  (Q6GZS7), ACINU_HUMAN (Q9UKV3), ACINU_MOUSE (Q9JIX8), 
AIM34_ASHGO (Q75CC0), AIM34_KLULA (Q6CUC1), AIM34_LACTC (C5DEP0), 
AIM34_YARLI (Q6CFD4), AIM34_YEAS1 (B3LLQ4), AIM34_YEAS2 (C7GLB5), 
AIM34_YEAS6 (B5VPC6), AIM34_YEAS7 (A6ZM65), AIM34_YEAS8 (C8ZEK9), 
AIM34_YEAST (Q03673), AIM34_ZYGRC (C5DTC6), ARP_ARATH   (P45951), 
CCAR1_HUMAN (Q8IX12), CCAR1_MOUSE (Q8CH18), CCAR1_XENLA (Q641G3), 
CCE1_SCHPO  (Q10423), DPPA2_HUMAN (Q7Z7J5), ERI1_CAEEL  (O44406), 
ERI1_HUMAN  (Q8IV48), ERI1_MOUSE  (Q7TMF2), ERI1_RAT    (Q5FVR4), 
ERI1_SCHPO  (Q08I43), HNRL1_HUMAN (Q9BUJ2), HNRL1_MOUSE (Q8VDM6), 
HNRL2_HUMAN (Q1KMD3), HNRL2_MOUSE (Q00PI9), HNRPU_HUMAN (Q00839), 
HNRPU_MOUSE (Q8VEK3), KU70_ARATH  (Q9FQ08), KU70_ASPOR  (Q2MHH4), 
KU70_ASPSO  (Q2MHH3), KU70_CHAGB  (Q2H0I3), KU70_COCIM  (Q1DU75), 
KU70_EMENI  (Q5AVC7), KU70_NEUCR  (Q7SA95), KU70_ORYSJ  (Q7F1M0), 
KU70_PHANO  (Q0U5F2), KU70_RHIAP  (Q26228), KU70_SCHPO  (O94395), 
MASTR_BOVIN (A7E346), MASTR_HUMAN (Q6ZN01), MASTR_MOUSE (Q0ZCJ7), 
MKL1_HUMAN  (Q969V6), MKL1_MOUSE  (Q8K4J6), MKL2_HUMAN  (Q9ULH7), 
MKL2_MOUSE  (P59759), MRTFA_XENLA (Q8AYC2), MRTFB_XENLA (Q8AYC1), 
MYCD_HUMAN  (Q8IZQ8), MYCD_MOUSE  (Q8VIM5), MYCD_PIG    (Q7YR76), 
MYCD_RAT    (Q8R5I7), PARP1_MAIZE (Q9ZSV1), PARP1_ORYSJ (Q7EYV7), 
PARP2_ARATH (Q11207), PARP2_MAIZE (O50017), PARP3_SOYBN (Q9SWB4), 
PIAS1_HUMAN (O75925), PIAS1_MOUSE (O88907), PIAS2_HUMAN (O75928), 
PIAS2_MOUSE (Q8C5D8), PIAS2_RAT   (Q6AZ28), PIAS3_HUMAN (Q9Y6X2), 
PIAS3_MOUSE (O54714), PIAS3_RAT   (O70260), PIAS4_HUMAN (Q8N2W9), 
PIAS4_MOUSE (Q9JM05), PLI1_SCHPO  (O94451), PRP2A_ORYSJ (Q5Z8Q9), 
RAD18_ASHGO (Q75EN0), RAD18_ASPFU (Q4WZJ6), RAD18_CANAL (Q5A4N5), 
RAD18_CANGA (Q6FPI4), RAD18_DEBHA (Q6BLM3), RAD18_EMENI (Q02398), 
RAD18_HUMAN (Q9NS91), RAD18_KLULA (Q6CTZ8), RAD18_MOUSE (Q9QXK2), 
RAD18_NEUCR (P33288), RAD18_SCHPO (O74747), RAD18_YARLI (Q6CHI1), 
RAD18_YEAST (P10862), SAFB1_HUMAN (Q15424), SAFB1_MOUSE (D3YXK2), 
SAFB1_PONAB (Q5R452), SAFB1_RAT   (O88453), SAFB2_HUMAN (Q14151), 
SAFB2_MOUSE (Q80YR5), SARNP_HUMAN (P82979), SARNP_MOUSE (Q9D1J3), 
SARNP_PONAB (Q5R4V4), SARNP_RAT   (Q498U4), SF3B2_HUMAN (Q13435), 
SIZ1_ARATH  (Q680Q4), SIZ1_ORYSJ  (Q6L4L4), SIZ1_YEAST  (Q04195), 
SIZ2_ORYSJ  (Q6ASW7), SIZ2_YEAST  (Q12216), SLTM_HUMAN  (Q9NWH9), 
SLTM_MOUSE  (Q8CH25), SLTM_XENLA  (Q498L2), THO1_YEAST  (P40040), 
XRCC6_CHICK (O93257), XRCC6_HUMAN (P12956), XRCC6_MOUSE (P23475), 
Y0785_DICDI (Q54UW0), Y0787_DICDI (Q54UV9), Y0809_DICDI (Q54UV8), 
Y1095_DICDI (Q54UG3), Y1301_DICDI (Q54UG2), YCW3_SCHPO  (O74871)
» More

UniProtKB/Swiss-Prot
False negative sequences
16 sequences

C3H62_ORYSJ (Q338N2), DEK_HUMAN   (P35659), DEK_MOUSE   (Q7TNV0), 
DEK_RAT     (Q6AXS3), DPPA2_MOUSE (Q9CWH0), KU70_DICDI  (Q54MA9), 
NEW25_SCHPO (G2TRT4), PARP3_MEDTR (Q1SGF1), RFFL_HUMAN  (Q8WZ73), 
RFFL_MOUSE  (Q6ZQM0), RFFL_RAT    (Q8CIN9), RNF34_BOVIN (Q5E9J6), 
RNF34_HUMAN (Q969K3), RNF34_MOUSE (Q99KR6), RNF34_PONAB (Q5NVC7), 
RNF34_RAT   (Q6AYH3)
» More

PDB
[Detailed view]
16 PDB

1H1J; 1JEQ; 1JJR; 1KCF; 1V66; 1ZBH; 1ZBU; 1ZRJ; 2DO1; 2DO5; 2KVU; 2KW9; 2RNN; 2RNO; 2WQG; 4L8R
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