Entry: PS50865

General information about the entry

Entry name [info] ZF_MYND_2
Accession [info] PS50865
Entry type [info] MATRIX
Date [info] JAN-2003 (CREATED); OCT-2013 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC50865
Associated ProRule [info] PRU00134

Name and characterization of the entry

Description [info] Zinc finger MYND-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=38;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=35;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.2840000; R2=0.0086421; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1416.4591064; R2=3.9469154; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=835; H_SCORE=4712; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=604; H_SCORE=3800; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='C'; M=-10,-11, 99,-22,-25,-20,-25,-24,-28,-25,-22,-20, -8,-37,-25,-25, -7, -8,-13,-48,-28,-25;
/M: SY='Y'; M= -5, -9,-24,-12,-11, -4,-17,  0,-13, -8,-10, -8, -7,-20, -9, -4, -7, -3,-11,  4,  7,-11;
/M: SY='N'; M= -8,  0,-23, -6, -7,-10,-11, -5, -9, -7,-13, -9,  7,-20, -5, -8, -1, -2,-10,-15, -2, -6;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G'; M= -5, -5,-26, -7,-12,-12, 30,-15,-26,-17,-17,-14,  2,-20,-16,-16, -2,-13,-22,-21,-18,-14;
/M: SY='R'; M= -7,  1, -8, -4,  1,-22,-16, -8,-25, 15,-23,-14,  6,-16,  1, 18,  0,  0,-17,-29,-15,  0;
/M: SY='W'; M= -8,-10,-28, -8,  5,-11,-12,-13,-21, -2,-18,-15, -9,-15, -2, -3, -2, -5,-19,  9, -5,  2;
/M: SY='A'; M= 17, -4,-11, -8,  4,-23,-10,-12,-17, -1,-16,-10, -3, -7,  1, -9,  4, -4,-12,-26,-19,  2;
/I:         I=-4; MD=-21;
/M: SY='T'; M=  1, -3,-18, -5, -2,-14, -9,-11, -8, -9, -7, -3, -2, -7, -5,-11,  2,  4, -7,-25,-13, -4; D=-4;
/I:         I=-4; MD=-21;
/M: SY='Y'; M= -6, -3,-18, -2,  2, -4,-13,  1,-14,  2,-13, -8, -3, -6, -2, -2, -2, -4,-12,-12,  3,  0; D=-4;
/I:         I=-4; MI=0; MD=-21; IM=0; DM=-21;
/M: SY='K'; M=  3, -4,-14, -6,  0,-13, -9,  0, -9,  7, -7,  1, -4, -8,  4,  2, -4, -5, -7,-12, -5,  2; D=-4;
/I:         I=-4; DM=-21;
/M: SY='K'; M= -8, -3,-24, -4,  5,-21,-20,  0,-22, 18,-17, -8, -1,-13,  4, 18, -3,  2,-15,-24, -8,  3;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         I=-6; MD=-29;
/M: SY='S'; M=  3, -4,-16, -5, -1,-17,  1,-10,-19, -4,-18,-13,  2,-12, -2,  1, 16,  6,-11,-28,-16, -2; D=-6;
/I:         I=-6; MI=-29; MD=-29; IM=-29; DM=-29;
/M: SY='R'; M= -4, -9,-24,-10, -4,-15,  4, -9,-23,  4,-15, -9, -4,-16, -1, 14, -5,-10,-17,-17,-12, -4; D=-6;
/I:         I=-6; DM=-29;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='R'; M=-13, -2,-31, -5,  1,-21,-12,  1,-25, 16,-24,-10,  4,-17, 11, 19, -8,-12,-25, -4, -3,  5;
/M: SY='R'; M=-10,  1,-21, -4, -6, -8,-17, -6,-13,  3,-15, -7,  7,-19, -3, 10, -1,  1, -9,-25, -8, -4;
/M: SY='A'; M= 17,-11,-12,-16,-10,-12,-15,-21, -2,-12, -5, -5,-11,-15,-13,-16,  8, 15,  9,-27,-14,-11;
/M: SY='R'; M= -4,-12,-27,-13, -5,-17,-16,  0,-19,  9,-18, -7, -8,-13,  0, 14, -8,-10,-14, -4, -5, -4;
/M: SY='Y'; M=-20,-20,-30,-20,-20, 30,-30, 20,  0,-10,  0,  0,-20,-30,-10,-10,-20,-10,-10, 30, 80,-20;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='S'; M=  6,  1, -6,  1, -3,-22,  5,-12,-24,-12,-29,-21,  8,-13, -4,-12, 31, 12,-13,-38,-22, -3;
/M: SY='K'; M= -4, -6,-25, -7,  3,-24,-18,-10,-18, 17,-20, -9, -3, -7,  7, 15, -1, -3,-12,-24,-13,  4;
/M: SY='E'; M= -6,  2,-25,  6, 25,-13,-18, -7,-23,  6,-18,-15, -1, -8,  4, -1,  1, -3,-19,-24,-11, 15;
/M: SY='C'; M=-12,-16, 86,-23,-23,-20,-28, -1,-30,-26,-20,-16,-13,-36,-21,-23,-10,-12,-14,-46,-19,-23;
/M: SY='Q'; M=-10,  0,-30,  0, 20,-40,-20, 10,-20, 10,-20,  0,  0,-10, 60, 10,  0,-10,-30,-20,-10, 40;
/M: SY='R'; M= -5,-10,-23,-11, -3,-18,-20,  2,-12,  7,-11, -2, -7,-18,  6, 11, -6, -5, -7,-21, -4,  0;
/M: SY='K'; M=  0, -6,-22, -7,  0,-19,-13,-13,-13,  3, -8, -6, -5,-14,  0,  0, -2, -3, -9,-24,-12, -1;
/M: SY='D'; M= -1, 22,-24, 27, 10,-29,-10, 16,-29, -4,-22,-18, 11,-12,  1, -9,  1, -9,-22,-32,-12,  4;
/M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='E'; M=-10, -5,-27, -3,  4,-19,-15, -4,-17,  2,-10, -7, -4, -5,  2,  4, -7, -8,-17,-26,-12,  2;
/I:         I=-6; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='G'; M= -1, -5,-22, -7, -8,-15,  4,-12,-17, -7,-12,-10, -3,-18,-10,-10, -1, -3,-12,-20, -8, -9;
/M: SY='H'; M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='R'; M=-12, -3,-29, -3,  6,-27,-14,  4,-29, 28,-25, -9,  1,-14, 14, 30, -5,-10,-22,-22, -9,  8;
/M: SY='H'; M=-13, -3,-26, -3,  1,-17,-20,  9,-15,  4,-12, -2, -2,-12,  5,  8, -7, -7,-13,-24, -3,  1;
/M: SY='E'; M= -7, -8,-28, -9, 11,-10,-22,-14, -9, -7,-10,-10, -9,-13, -3,-12, -7, -5,-11,  1, -5,  4;
/M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_06 which contains 551'385 sequence entries.


Total number of hits 97 in 97 different sequences
Number of true positive hits 96 in 96 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 10
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.97 %
Recall (true positives / (true positives + false negatives)) 90.57 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] N_Hulo
Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Feature key [info] ZN_FING
Feature description [info] MYND-type
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
96 sequences

ANKY1_HUMAN (Q9P2S6    ), ANKY2_BOVIN (Q0VCS9    ), ANKY2_CHICK (Q5ZMD2    ), 
ANKY2_HUMAN (Q8IV38    ), ANKY2_MOUSE (Q3TPE9    ), ANMY1_MOUSE (Q8C0W1    ), 
ASHR1_ARATH (Q7XJS0    ), DAF25_CAEEL (Q9N3Q8    ), DEAF1_DROME (Q24180    ), 
DEAF1_HUMAN (O75398    ), DEAF1_MOUSE (Q9Z1T5    ), DEAF1_PANTR (O77562    ), 
DEAF1_RAT   (O88450    ), EGL9_CAEEL  (G5EBV0    ), EGLN1_HUMAN (Q9GZT9    ), 
EGLN1_MOUSE (Q91YE3    ), FB342_ARATH (Q9FK27    ), GACZ_DICDI  (Q55DW9    ), 
MSS51_HUMAN (Q4VC12    ), MSS51_MOUSE (Q9D5Z5    ), MSS51_RAT   (D3ZKV9    ), 
MTG16_CHICK (Q5F3B1    ), MTG16_HUMAN (O75081    ), MTG16_MOUSE (O54972    ), 
MTG8R_HUMAN (O43439    ), MTG8R_MOUSE (O70374    ), MTG8R_XENLA (Q9IAB2    ), 
MTG8_HUMAN  (Q06455    ), MTG8_MOUSE  (Q61909    ), MUB1_ASPCL  (A1CBG9    ), 
MUB1_ASPFC  (B0Y1D1    ), MUB1_ASPFN  (B8NKS1    ), MUB1_ASPFU  (Q4WVI6    ), 
MUB1_ASPNC  (A2RA63    ), MUB1_ASPOR  (Q2U685    ), MUB1_ASPTN  (Q0CW83    ), 
MUB1_EMENI  (O42631    ), MUB1_NEOFI  (A1DDX0    ), MUB1_SCHPO  (P87311    ), 
MUB1_YEAST  (Q03162    ), PDCD2_BOVIN (Q2YDC9    ), PDCD2_HUMAN (Q16342    ), 
PDCD2_MOUSE (P46718    ), PDCD2_RAT   (P47816    ), PKCB1_HUMAN (Q9ULU4    ), 
SET14_CAEEL (Q09415    ), SET6_SCHPO  (O94256    ), SMY2A_DANRE (Q5BJI7    ), 
SMY2A_XENLA (Q7ZXV5    ), SMY2B_DANRE (Q5RGL7    ), SMY2B_XENLA (Q6GN68    ), 
SMYD1_HUMAN (Q8NB12    ), SMYD1_MOUSE (P97443    ), SMYD2_BOVIN (Q0P585    ), 
SMYD2_CHICK (E1C5V0    ), SMYD2_HUMAN (Q9NRG4    ), SMYD2_MOUSE (Q8R5A0    ), 
SMYD2_PIG   (C3RZA1    ), SMYD2_RAT   (Q7M6Z3    ), SMYD3_HUMAN (Q9H7B4    ), 
SMYD3_MOUSE (Q9CWR2    ), SMYD4_CHICK (Q5F3V0    ), SMYD4_HUMAN (Q8IYR2    ), 
SMYD4_MOUSE (Q8BTK5    ), SMYD4_PONAB (Q5R5X9    ), TDRD1_DANRE (Q58EK5    ), 
TDRD1_HUMAN (Q9BXT4    ), TDRD1_MOUSE (Q99MV1    ), TDRD1_ORYLA (A9CPT4    ), 
UBP15_ARATH (Q9FPS9    ), UBP16_ARATH (Q9SB51    ), UBP17_ARATH (Q9FKP5    ), 
UBP18_ARATH (Q67XW5    ), UBP19_ARATH (Q9SJA1    ), UBP19_HUMAN (O94966    ), 
UBP19_MOUSE (Q3UJD6    ), UBP19_RAT   (Q6J1Y9    ), Y2140_DICDI (Q54DL6    ), 
Y2454_DICDI (Q54D67    ), Y4059_DICDI (Q54Q80    ), Y7331_DICDI (Q54ZX8    ), 
YR331_MIMIV (Q5UQS2    ), ZMY10_DANRE (F1QN74    ), ZMY10_DROME (Q9VU41    ), 
ZMY10_HUMAN (O75800    ), ZMY10_MOUSE (Q99ML0    ), ZMY10_RAT   (Q6AXZ5    ), 
ZMY10_XENLA (Q5FWU8    ), ZMY11_HUMAN (Q15326    ), ZMY11_MOUSE (Q8R5C8    ), 
ZMY12_HUMAN (Q9H0C1    ), ZMY15_HUMAN (Q9H091    ), ZMY15_MOUSE (Q8C0R7    ), 
ZMY19_HUMAN (Q96E35    ), ZMY19_MOUSE (Q9CQG3    ), ZMY19_RAT   (Q7TSV3    )
» more

UniProtKB/Swiss-Prot
False negative sequences
10 sequences

ATXR2_ARATH (Q5PP37    ), BIG_ARATH   (Q9SRU2    ), BIG_ORYSJ   (B9G2A8    ), 
SMYD5_CHICK (Q5ZIZ2    ), SMYD5_HUMAN (Q6GMV2    ), SMYD5_MOUSE (Q3TYX3    ), 
SMYD5_XENLA (Q6GPQ4    ), Y3589_DICDI (Q557F7    ), Y3591_DICDI (Q557F6    ), 
Y8495_DICDI (Q54IV4    )
» more

UniProtKB/Swiss-Prot
False positive sequences
1 sequence

FB76_ARATH  (Q9FYF9    )

		
PDB
[Detailed view]
36 PDB

2D8Q; 2DAN; 2DJ8; 2JW6; 2OD1; 2ODD; 3MEK; 3N71; 3OXF; 3OXG; 3OXL; 3PDN; 3QWP; 3QWV; 3QWW; 3RIB; 3RU0; 3S7B; 3S7D; 3S7F; 3S7J; 3TG4; 3TG5; 4A24; 4O6F; 4WUY; 4YND; 5ARF; 5ARG; 5CCL; 5CCM; 5EX0; 5EX3; 5HDA; 5HI7; 5HQ8
» more

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