|PROSITE documentation PDOC50865|
The MYND-type zinc finger was called after the three best characterized members of the family (MYeloid translocation protein 8 (MTG8/ETO), Nervy protein and Deaf-1) . In MTG8 and Bop proteins this domain is important for the recruitment of a repressive complexe containing histone deacetylase (HDAC) activity [2,3]. In M2-type chronic leukemia where AML1 is fused to MTG8, AML1, normaly a transcriptional activator, is converted into a transcriptional repressor. The MYND domain of MTG8 is essential for this conversion and seems to function by recruiting the nuclear co-repressor N-CoR/mSin3A and HDACs complexes to DNA sites specified by AML1 .
The MYND-type zinc finger contains 8 amino acids that can coordinate 2 zinc atoms.
Some proteins containing a MYND-type zinc finger are listed below:
The profile and the pattern we developed cover the whole domain.Last update:
January 2003 / First entry.
PROSITE methods (with tools and information) covered by this documentation:
|1||Authors||Gross C.T., McGinnis W.|
|Title||DEAF-1, a novel protein that binds an essential region in a Deformed response element.|
|Source||EMBO J. 15:1961-1970(1996).|
|2||Authors||Gelmetti V., Zhang J., Fanelli M., Minucci S., Pelicci P.G., Lazar M.A.|
|Title||Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.|
|Source||Mol. Cell. Biol. 18:7185-7191(1998).|
|3||Authors||Gottlieb P.D., Pierce S.A., Sims R.J., Yamagishi H., Weihe E.K., Harriss J.V., Maika S.D., Kuziel W.A., King H.L., Olson E.N., Nakagawa O., Srivastava D.|
|Title||Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis.|
|Source||Nat. Genet. 31:25-32(2002).|
|4||Authors||Scarr R.B., Sharp P.A.|
|Title||PDCD2 is a negative regulator of HCF-1 (C1).|