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PROSITE documentation PDOC50865

Zinc finger MYND-type signature and profile





Description

The MYND-type zinc finger was called after the three best characterized members of the family (MYeloid translocation protein 8 (MTG8/ETO), Nervy protein and Deaf-1) [1]. In MTG8 and Bop proteins this domain is important for the recruitment of a repressive complexe containing histone deacetylase (HDAC) activity [2,3]. In M2-type chronic leukemia where AML1 is fused to MTG8, AML1, normaly a transcriptional activator, is converted into a transcriptional repressor. The MYND domain of MTG8 is essential for this conversion and seems to function by recruiting the nuclear co-repressor N-CoR/mSin3A and HDACs complexes to DNA sites specified by AML1 [2].

The MYND-type zinc finger contains 8 amino acids that can coordinate 2 zinc atoms.

Some proteins containing a MYND-type zinc finger are listed below:

  • Mammalian MTG8/ETO protein. MTG8 is part of a high molecular weight complex that contains co-repressors and HDACs.
  • Drosophila Nervy protein, a homologue of MTG8.
  • Animal Deformed epidermal autoregulatory factor 1 (Deaf-1). It was first identified in drosophila as a sequence-specific DNA binding protein that was isolated as a putative cofactor of the Hox protein Deformed (Dfd).
  • Vertebrate Bop protein. In mouse it is expressed specifically in cardiac and muscle precursors before differentiation of these lineages.
  • Mammalian programmed cell death protein 2 (PDCD2/RP8). It interacts with N-CoR/mSin3A complexes and with Host cell factor 1 (HCF1), a component of the C1 complex [4].
  • Adenovirus 5 E1A-binding protein (BS69). It binds to the transactivation domain of the adenovirus type 5 E1A 32 kda protein (289R) and inhibits its transactivating activity.

The profile and the pattern we developed cover the whole domain.

Last update:

January 2003 / First entry.

Technical section

PROSITE methods (with tools and information) covered by this documentation:

ZF_MYND_2, PS50865; Zinc finger MYND-type profile  (MATRIX)

ZF_MYND_1, PS01360; Zinc finger MYND-type signature  (PATTERN)


References

1AuthorsGross C.T., McGinnis W.
TitleDEAF-1, a novel protein that binds an essential region in a Deformed response element.
SourceEMBO J. 15:1961-1970(1996).
PubMed ID8617243

2AuthorsGelmetti V., Zhang J., Fanelli M., Minucci S., Pelicci P.G., Lazar M.A.
TitleAberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.
SourceMol. Cell. Biol. 18:7185-7191(1998).
PubMed ID9819405

3AuthorsGottlieb P.D., Pierce S.A., Sims R.J., Yamagishi H., Weihe E.K., Harriss J.V., Maika S.D., Kuziel W.A., King H.L., Olson E.N., Nakagawa O., Srivastava D.
TitleBop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis.
SourceNat. Genet. 31:25-32(2002).
PubMed ID11923873
DOI10.1038/ng866

4AuthorsScarr R.B., Sharp P.A.
TitlePDCD2 is a negative regulator of HCF-1 (C1).
SourceOncogene 21:5245-5254(2002).
PubMed ID12149646
DOI10.1038/sj.onc.1205647



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Miscellaneous

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