Entry: PS51234

Forthcoming changes to the profile format
General information about the entry

Entry name [info] TSP3
Accession [info] PS51234
Entry type [info] MATRIX
Date [info] MAR-2007 (CREATED); OCT-2013 (DATA UPDATE); JUL-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC51234
Associated ProRule [info] PRU00634

Name and characterization of the entry

Description [info] Thrombospondin type-3 (TSP3) repeat profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=36;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=36;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8454413; R2=0.0060809; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2082.04348; R2=11.63043; TEXT='HScore';
/CUT_OFF: LEVEL=0; SCORE=2164; N_SCORE=15.0; H_SCORE=25331; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=766; N_SCORE=6.5; H_SCORE=10979; MODE=1; TEXT='R?';
/DEFAULT: M0=-33; D=-120; I=-120; B1=-200; E1=-200; MI=-305; MD=-305; IM=-305; DM=-305;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-305; BD=-305;
/M: SY='E'; M= -20,  12,  13,  50, -41, -50, -41, -19,  36,  -5, -18, -20, -49,  11,  30, -25,   8, -38, -61, -21;
/M: SY='D'; M= -51, -64, 108, -17, -70, -47, -37, -66, -39, -67, -65,  22,  -6, -38, -47, -39, -40, -43, -85, -54;
/M: SY='T'; M=  12, -49,   4, -42,   4, -32,  -1, -41, -14, -47, -21, -19, -49, -42, -17,  42,  62,  10, -62, -13;
/M: SY='D'; M= -50, -63, 106,  -8, -70, -30, -36, -68, -38, -68, -65,  33,  -6, -38, -47, -38, -40, -66, -84, -55;
/M: SY='G'; M=  -8, -58, -43,  -1, -56,  58, -46, -33,  13,  -2, -38,  11, -53, -15,  28,   9, -32, -34, -60, -52;
/M: SY='D'; M= -50, -61, 103, -19, -69, -45, -34, -68, -37, -68, -64,  58, -52, -37, -45, -37, -38, -66, -85, -54;
/M: SY='G'; M= -35, -60, -12, -43, -65,  90, -52, -39, -12, -61, -56, -24, -52, -33, -12, -19, -39, -63, -58, -59;
/M: SY='W'; M= -37, -59, -54,   3,  -2, -62,  10,  19,   3,  -4,  -5, -51, -57,   2,  23, -40, -15,  44,  81,  -3;
/M: SY='G'; M= -38,-123, -97,-113,-133, 185,-108,-143,-103,-138,-116, -72,  55,-100, -76, -68,-101,-132,-116,-123;
/M: SY='D'; M= -51, -63, 109, -17, -71, -46, -36, -69, -38, -68, -66,  31, -51, -37, -46, -38, -40, -66, -86, -54;
/I:         I=-31; MI=0; MD=-78; IM=0; DM=-78;
/M: SY='A'; M=  66, -49, -41, -24, -51, -19, -43,   5, -21, -19, -22, -47, -52, -27, -30,  -2,  -9,  28, -62, -50;
/M: SY='C'; M= -90, 298,-129,-130,-110,-121,-129,-124,-121,-105,-106,-102,-151,-137,-134, -95, -90, -99,-170,-132;
/I:         I=-17; MD=-44;
/M: SY='D'; M= -37, -81,  67,  37, -85, -70, -58, -44, -17, -79, -76, -46, -66, -15, -59, -39, -35, -76, -92, -72; D=-17;
/I:         I=-17; MI=-44; MD=-44; IM=-44; DM=-44;
/M: SY='D'; M= -41, -76,  41,  -9, -57,  -7, -62, -71, -21, -48, -69, -11,  -6, -58, -49, -11,  18, -37, -85, -28; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D'; M= -69, -83,  92, -34, -88, -66, -55, -87, -54, -85, -83, -38, -22, -55, -15, -57, -59, -83,-101, -71; D=-17;
/I:         I=-17; DM=-44;
/M: SY='F'; M=   4, -69,   5, -28,  60, -37, -62,   9, -65, -40,  -8, -62, -72, -48, -49, -32, -57, -16, -55,   5; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D'; M= -63,  13,  94, -32, -83, -62, -52, -81, -53, -80, -78, -34, -65, -53, -62, -27, -17, -77, -99, -68; D=-17;
/I:         I=-17; DM=-44;
/M: SY='N'; M= -44, -69, -17, -57, -71,  37, -32, -67, -19, -24, -29,  68, -69,  -4, -58, -47, -53, -36, -80, -67; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D'; M= -14, -73,  92, -31, -79, -59, -52, -71, -31, -74, -72, -35, -28, -51, -58, -49, -23, -27, -93, -65; D=-17;
/I:         I=-17; DM=-44;
/M: SY='G'; M= -34, -66, -13, -33, -71,  45, -58, -70,   6, -42, -62,   4, -61, -30, -37,  19,  25, -65, -75, -65; D=-17;
/I:         I=-17; DM=-44;
/M: SY='I'; M= -57, -69, -73, -73, -32, -78, -69,  61, -68, -13, -36, -11, -30, -67, -46, -51, -51,  38, -66,  15; D=-17;
/I:         I=-17; DM=-44;
/M: SY='P'; M= -50, -73, -17, -36, -33, -67,  26,   4, -25,  -8,   4, -28,  58, -23, -22, -25,  -6, -11, -74, -38; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D'; M= -60,  46,  70,  -9, -76, -56, -47, -77, -47, -77, -71,  61, -66, -48, -17, -39, -49, -74, -93, -67; D=-17;
/I:         I=-17; DM=-44;
/M: SY='I'; M= -16, -70,  -2,   8, -42, -18,   2,  17, -23,  -9, -39, -35, -18, -22,   3, -14,  -2, -28, -71, -15; D=-17;
/I:         I=-17; DM=-44;
/M: SY='K'; M= -32, -71,  13,   1, -34, -61, -57,   3,  16,   5,  -1, -54,  -4,   5,   7, -35, -35, -17, -70, -32; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D'; M= -52, -65, 113, -15, -72, -48, -37, -70, -39, -68, -67, -19, -51, -38, -47, -39, -41, -67, -87, -54;
/M: SY='N'; M= -13, -51,   2, -41, -57, -38,  14, -36, -36, -57, -48, 103, -56, -37, -43,  -2, -26,  12, -77, -52;
/M: SY='C'; M= -90, 298,-129,-130,-110,-121,-129,-124,-121,-105,-106,-102,-151,-137,-134, -95, -90, -99,-170,-132;
/M: SY='P'; M= -48, -69, -53, -42, -57, -47, -53,   0, -43, -15, -23, -55, 105,  -4,   8, -38, -43,  -6,  15, -56;
/M: SY='E'; M= -19, -57,   8,  44, -17, -54, -21, -38,  21,  25, -17,  21, -52, -20,   3,  -1, -16, -38, -54,  25;
/M: SY='N'; M= -24, -53, -33, -27, -39, -52, -28,  12, -23,  15, -17,  61,  -4, -26, -49,  -3,  -7,  47, -67, -47;
/M: SY='P'; M=  30, -58, -33, -27, -12, -47,   4, -42,  11, -36, -45,  -2,  73, -41, -21,  15, -31, -14, -54,  28;
/M: SY='N'; M= -32, -53,  -1,  30, -61, -26, -30, -59,  -6, -63,  -3, 103, -53, -31, -38,  -6, -33, -59, -74, -55;
/M: SY='P'; M= -21, -59, -22, -47, -22, -26, -54,  33, -42, -37, -39, -19,  72, -38, -31,  31,  -8,  30, -63, -50;
/M: SY='D'; M= -27, -56,  58, -21,   3,  28,  32, -55, -35, -32,  -8,  18, -51, -28, -21,  12,  36, -52, -66, -30;
/M: SY='Q'; M= -22, -62, -30,  -2, -58, -53,   6, -46, -23,  10,  -5, -38, -52, 105, -31, -20,  -1, -26, -58, -43;
/I:         E1=0; IE=-305; DE=-305;
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Post-processing [info]

COMPETES_HIT_WITH PS51236

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_08 which contains 546'238 sequence entries.


Total number of hits 176 in 22 different sequences
Number of true positive hits 176 in 22 different sequences
Number of 'unknown' hits
Number of false positive hits
Number of false negative sequences 1
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.44 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] N_Hulo
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 8
Feature key [info] REPEAT
Feature description [info] TSP type-3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
22 sequences

COMP_BOVIN  (P35445), COMP_HUMAN  (P49747), COMP_MOUSE  (Q9R0G6), 
COMP_RAT    (P35444), TSP1_BOVIN  (Q28178), TSP1_HUMAN  (P07996), 
TSP1_MOUSE  (P35441), TSP1_XENLA  (P35448), TSP2_BOVIN  (Q95116), 
TSP2_CHICK  (P35440), TSP2_HUMAN  (P35442), TSP2_MOUSE  (Q03350), 
TSP3A_DANRE (Q8JHW2), TSP3B_DANRE (Q1L8P7), TSP3_HUMAN  (P49746), 
TSP3_MOUSE  (Q05895), TSP4B_DANRE (Q8JGW0), TSP4_BOVIN  (Q3SWW8), 
TSP4_HUMAN  (P35443), TSP4_MOUSE  (Q9Z1T2), TSP4_RAT    (P49744), 
TSP4_XENLA  (Q06441)
» More

UniProtKB/Swiss-Prot
False negative sequences
1 sequence

ARP_EUGGR   (Q04732)

		
PDB
[Detailed view]
4 PDB

1UX6; 1YO8; 2RHP; 3FBY

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