PROSITE entry PS51788
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General information about the entry
| Entry name [info] | CULT |
| Accession [info] | PS51788 |
| Entry type [info] | MATRIX |
| Date [info] |
01-JAN-2016 CREATED;
07-APR-2021 DATA UPDATE; 27-MAR-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51788 |
| Associated ProRule [info] | PRU01124 |
Name and characterization of the entry
| Description [info] | CULT domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=108; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=103; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7562752; R2=0.0085534; TEXT='-LogE'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=16484.3242188; R2=6.7289991; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1140; H_SCORE=24155; N_SCORE=12.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=438; H_SCORE=19432; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-26; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='E'; M= -29, 23, -3, 27, -11, -13, -37, 7, -12, -19, 26, -2, -4, -20, -4, 8, -30, -7, -81, -27; /M: SY='D'; M= -25, -24, 41, 4, -14, 2, -35, -31, -19, -66, -50, 9, -10, -1, -18, 22, 25, -32, -82, -1; /M: SY='S'; M= 9, -76, -17, -5, 5, -31, -67, -15, -31, -6, -60, -10, -36, 10, -5, 16, 11, 13, -2, 9; /M: SY='L'; M= -70, -13, -88, -82, 34, -63, -76, 38, -39, 58, 9, -83, -36, -77, -78, -78, -66, 6, -71, -25; /M: SY='C'; M= -12, 52, -76, -69, -18, -66, -5, -17, 7, 36, -51, -45, -81, -19, 36, -55, -16, 10, -79, -9; /M: SY='C'; M= -65, 146, -83, -81, -75, -80, -83, -58, -25, -72, -27, -70, -93, -42, -82, -67, -40, -69,-102, -84; /M: SY='R'; M= 24, -45, -30, -42, -26, -21, -22, -30, 16, -73, -30, -39, -74, -5, 76, 1, -29, -50, -79, -35; /M: SY='H'; M= -8, -17, -11, -12, 5, -3, 56, -48, -23, -39, 16, 5, -74, 27, 28, 2, 0, -44, -11, -5; /M: SY='C'; M= -46, 146, -83, -84, -75, -79, -82, -80, -79, -71, -5, -27, -94, -86, -86, -53, -64, -69,-104, -84; /M: SY='G'; M= -28, -80, 3, -43, -80, 67, -4, -42, -9, -36, -25, 7, -73, 27, 11, -17, -33, -77, -81, -51; /M: SY='H'; M= 39, -7, -50, 2, -27, -21, 45, -15, -62, -7, -60, 3, -72, -21, -12, 19, 17, -30, -83, -36; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='P'; M= -16, -6, 20, 20, -26, -63, 18, -25, -28, -3, -63, 2, 50, -3, 12, -20, 2, -24, -84, -50; /M: SY='I'; M= -65, -8, -87, -57, -5, -91, -84, 75, -64, 16, -30, -80, -81, -51, -81, -74, -36, 47, -79, -60; /M: SY='T'; M= 56, 20, -49, -65, -30, -5, -71, -69, -33, -72, -67, -58, -69, -63, -32, 23, 61, -50, -84, -71; /M: SY='W'; M= -25, -79, 25, -36, -25, -56, 38, -75, 14, -63, -68, 26, -29, 18, 36, 25, 0, -29, 42, -30; /M: SY='K'; M= 1, 14, -38, -14, -44, -18, 12, -3, 20, -34, 4, -20, 12, -1, 16, 13, -16, -14, -77, 15; /M: SY='S'; M= -5, -11, 8, -12, -57, -15, -8, -78, 8, -45, -70, 26, -72, 3, 36, 50, -16, -60, -18, -45; /I: I=-36; MI=0; MD=-90; IM=0; DM=-90; /M: SY='D'; M= -12, -81, 75, 18, -31, -69, 32, -78, -23, -42, -14, 21, -72, 1, -44, -18, -48, -77, 49, 13; /M: SY='I'; M= -10, -44, -80, -57, -9, -66, -71, 42, -41, 29, 37, -74, -79, -22, 15, -24, -42, 29, -75, 0; /M: SY='F'; M= -55, -75, -82, -53, 59, -84, -7, 47, -61, 12, 25, -30, -42, -40, -47, -43, -34, 35, -68, -20; /M: SY='S'; M= -1, 23, 7, -8, -29, -26, 1, -27, -13, -39, -65, 39, 12, -6, -11, 40, -22, -2, -85, -43; /M: SY='M'; M= -30, -15, -77, -30, -27, -55, -17, 19, -8, 21, 84, -43, -22, -65, -7, -43, -20, 30, -79, -60; /M: SY='S'; M= -14, -75, -29, -35, -6, -7, 25, -38, -30, -60, -35, 40, 25, 3, 10, 51, -17, -54, -78, 5; /M: SY='S'; M= -8, -42, 34, 2, -57, 36, -39, -64, -22, -55, -35, 5, -48, -16, -35, 53, 7, -60, -85, -72; /M: SY='E'; M= 9, -18, 30, 42, -79, -31, -21, -63, -16, -37, -68, -44, 30, 9, -1, 18, 6, -25, -84, -48; /I: I=-15; MD=-37; /M: SY='H'; M= -24, -80, -1, 3, -16, 56, 59, -78, -20, -34, -22, -56, -38, -29, -68, 13, -42, -41, -6, -11; D=-15; /I: I=-15; MD=-37; /M: SY='P'; M= 25, -85, -78, -73, -61, -19, -40, -33, -5, -79, -74, -28, 51, -36, -77, -3, 4, 11, -93, -83; D=-15; /I: I=-15; MI=0; MD=-37; IM=0; DM=-37; /M: SY='V'; M= -17, 22, -31, -14, -33, -27, -22, 18, -48, 5, 9, -47, -38, 13, -35, 19, 20, 32, -83, -65; /M: SY='H'; M= -12, -79, -62, -57, -41, 33, 77, -75, -17, -63, -9, -39, -72, 65, -37, 19, -22, -40, -76, 19; /M: SY='T'; M= 26, -22, -67, -26, -21, -68, -7, 8, -33, 8, -2, -3, -71, -43, -68, 21, 45, 14, -79, -14; /M: SY='F'; M= -12, -42, -79, -77, 82, -80, 21, -51, -72, -1, 24, -47, -39, -72, -31, -70, -66, -12, -48, 75; /M: SY='V'; M= -11, 8, -28, -25, 23, -78, -39, -7, 3, -47, -54, -51, -21, -18, -27, -24, 10, 66, -80, -60; /M: SY='N'; M= -48, -71, -10, -60, -78, -27, -13, -55, -28, -42, -70, 114, -76, -54, -60, -49, -34, -51, -96, -73; /M: SY='P'; M= -8, -13, -66, -39, -84, -51, -69, -75, -64, -42, -70, -2, 108, -9, -73, 15, -58, -76, -83, -81; /M: SY='H'; M= 14, -30, -26, -51, 3, 6, 84, -44, -62, -10, -26, 5, -73, 31, -47, 26, -40, -55, -24, -10; /M: SY='G'; M= -21, -79, -15, -43, -82, 87, -4, -86, -25, -38, -73, -38, -49, -14, -30, -28, -46, -81, -79, -76; /M: SY='Y'; M= -27, 28, -23, -37, 25, -37, 22, 19, -40, -30, 3, -16, -18, -11, -20, -15, -44, 20, 25, 57; /M: SY='V'; M= -26, -75, -23, 16, -24, -43, -23, 21, -34, -29, -25, -66, -22, 23, 14, -16, -9, 53, -79, -6; /M: SY='H'; M= -50, -3, -41, -35, 84, -78, 95, -41, -50, -55, -25, -62, -79, 17, -64, -44, -68, -66, -59, 34; /M: SY='E'; M= -48, -47, 43, 73, -83, -60, 14, -83, -36, -68, -71, 5, -65, 40, 25, -21, -12, -78, -85, -45; /M: SY='M'; M= -61, -72, -80, -77, -4, -53, -75, 49, -74, 24, 52, -72, -38, -72, -76, -32, 31, 42, -5, -27; /M: SY='V'; M= 21, -71, -77, -51, -7, 4, -73, 32, -69, 17, 33, -50, -76, -46, -9, -30, -15, 39, -30, -60; /M: SY='T'; M= -12, 68, -65, -47, -70, -8, -70, -63, -58, -25, -62, -56, -34, -64, 20, -23, 85, -18, -87, -70; /M: SY='F'; M= -7, 31, -82, -77, 74, -79, -73, -41, -75, 16, -9, -74, -81, -37, -75, -29, -1, 48, -65, -20; /M: SY='S'; M= 8, -41, -31, -11, -51, -54, 22, -22, 39, -37, -63, 1, -70, 14, 29, 40, -20, -48, -8, 16; /M: SY='N'; M= 4, -32, -2, 9, -30, -22, 5, -69, 19, -24, -64, 38, 10, 28, 16, -6, 16, -23, -82, -66; /I: I=-29; MD=-75; /M: SY='A'; M= 67, 12, -74, -50, -69, -53, -75, 10, -29, -21, -20, -37, -46, -66, -59, -20, -1, 20, -82, -42; D=-29; /I: I=-29; MI=0; MD=-75; IM=0; DM=-75; /M: SY='D'; M= -18, -82, 35, 4, -54, -62, 12, -57, -20, -76, -29, 8, 29, 22, 16, -1, 16, -12, -88, -21; D=-29; /I: I=-29; DM=-75; /M: SY='N'; M= -23, -39, 11, -33, -40, 50, 13, -57, -22, -31, -66, 58, -71, -18, -13, 12, 4, -12, -83, -68; /M: SY='C'; M= -19, 76, -78, -30, -1, -79, -41, 2, -72, 42, -22, -73, -81, -71, -46, -13, -11, 33, -74, 20; /M: SY='A'; M= 35, -71, -23, -31, -35, -4, -14, -3, 5, -13, 0, -24, -40, -6, 19, 22, -15, 12, -26, -49; /M: SY='L'; M= -20, 9, -72, -35, 5, -31, 8, 7, -25, 35, -22, -50, 14, 7, -11, -14, 8, 4, 18, 12; /M: SY='H'; M= -2, -75, 0, 21, -17, -51, 28, 16, -22, -27, -20, -49, -52, -2, 20, 1, 3, 24, 1, 7; /M: SY='G'; M= -38, -77, -14, -23, -28, 76, 25, -65, -49, -58, -71, -52, -11, -10, -12, 15, 9, -77, -79, -70; /M: SY='P'; M= -2, -78, 6, 32, -73, -31, -23, -71, 3, -28, -18, 20, 37, 22, 26, 2, -11, -39, -78, 7; /I: I=-6; MI=0; MD=-15; IM=0; DM=-15; /M: SY='P'; M= -5, -89, -41, -18, -6, -61, -73, -44, -66, -61, -71, -75, 91, -68, -2, -24, -39, -52, 74, 12; D=-6; /I: I=-6; DM=-15; /M: SY='S'; M= -22, -7, -13, 3, -40, -62, 6, -35, -58, -52, -64, -6, -67, 21, -63, 69, 41, -17, -80, 8; /M: SY='T'; M= 5, -42, -4, 9, -32, -21, -37, -40, 9, -9, -12, -12, 29, -18, -34, 14, 50, -41, -79, -14; /M: SY='E'; M= 5, -12, 23, 69, -44, -59, 29, -56, 14, -74, -68, -54, -64, 33, -19, -19, 7, -51, -82, -43; /M: SY='H'; M= -8, -24, 37, -60, 57, -59, 83, -68, -40, -62, -13, 0, -77, -27, -39, -20, -64, -46, -63, 56; /M: SY='S'; M= -48, 6, -28, -61, -74, -43, -64, -70, -60, -54, -69, -25, -66, -56, -66, 85, 62, -43, -87, -69; /M: SY='W'; M= -77, -94, -96, -48, 44, -78, -91, -68, -75, -34, -69, -23, -83, -75, -77, -81, -83, -54, 162, -3; /M: SY='F'; M= -78, -76, -87, -84, 112, -59, -67, -34, -80, -46, -54, -41, -34, -87, -77, -76, -70, -58, -4, 36; /M: SY='P'; M= -23, -87, 19, 14, -43, -71, -22, -73, -26, -79, -24, -65, 101, -19, -32, -20, -37, -28, -83, -77; /M: SY='G'; M= -54, -80, 20, -29, -86, 92, -71, -93, -68, -88, -79, -37, -45, -66, -26, -37, -69, -86, -80, -79; /M: SY='Y'; M= -43, -83, -74, -76, 33, -56, 14, -26, -69, -45, -31, -73, -33, -66, -42, -44, -46, -63, -37, 118; /M: SY='A'; M= 50, -8, -12, 13, -45, -19, -19, -25, -15, -40, -38, 8, -70, 5, -16, 33, -27, -44, -81, -31; /M: SY='W'; M= -75, -98, -97, -78, -47, -75, -96, -75, -24, -36, -74, -90, -41, -71, -37, -10, -83, -86, 168, -34; /M: SY='T'; M= -48, 39, -38, -16, -75, -72, -12, -53, -6, -53, -29, -2, -70, 49, 46, 5, 60, -47, -84, -31; /M: SY='I'; M= -34, 30, -11, -48, 17, -82, -46, 63, -73, -13, 2, -28, 14, -73, -45, -33, -41, 28, -75, 5; /M: SY='C'; M= 47, 67, -77, -46, -63, -40, -50, 30, -72, 13, -10, -70, -77, -69, -48, -15, -22, 10, -81, -23; /M: SY='V'; M= -16, -2, -68, -30, -4, -74, 16, 1, -39, 14, -1, 14, -76, 9, -2, 16, 3, 28, -77, 7; /M: SY='C'; M= -64, 144, -43, -51, -43, -79, -82, -78, -78, -70, -8, -70, -32, -84, -84, -38, -64, -49, -5, -80; /M: SY='P'; M= 16, 31, -63, -26, -44, -6, -64, -51, 16, -34, -35, 16, 42, -35, 27, 27, -13, -51, -81, -33; /M: SY='R'; M= -10, -12, -23, -60, -18, -2, 3, -34, 11, -46, -44, 24, -73, -2, 45, 32, 5, -25, -80, -16; /M: SY='C'; M= -65, 144, -84, -83, -30, -47, -83, -51, -50, -40, -69, -71, -93, -86, -84, -46, -64, -46, -99, -81; /M: SY='G'; M= -7, -77, -19, -28, -30, 42, 30, -75, -2, -37, 6, -8, -71, 15, 20, 27, -10, -72, 23, -8; /M: SY='S'; M= 7, -72, 0, -23, -21, -8, 17, -56, -21, -27, -64, 33, -71, 0, 16, 39, 24, -22, -30, -25; /M: SY='H'; M= -71, -81, -23, -59, 39, -74, 126, -50, -63, -23, -56, -3, -5, 9, -59, -40, -68, -76, -85, -41; /M: SY='L'; M= -66, -21, -81, -40, -50, -85, -10, 39, -50, 61, 32, -24, -81, -70, -34, -33, -62, 21, -78, -58; /M: SY='G'; M= -19, -78, -68, -77, -82, 94, -73, -84, -70, -65, -22, -54, -71, -69, -35, -28, -68, -34, -77, -78; /M: SY='W'; M= -77, -34, -49, -57, -5, -53, -99, -50, -75, -42, -74, -92, -82, -74, -78, -42, -86, -85, 169, -33; /M: SY='R'; M= 3, -78, -64, 1, -22, -1, 33, -30, 32, -11, 2, -42, -73, 18, 34, -10, -27, -55, -72, 28; /M: SY='F'; M= -75, -76, -84, -81, 105, -83, -8, -54, -45, -48, -55, -76, -45, -81, -24, -34, -68, -18, -45, 54; /M: SY='T'; M= -13, -39, 5, 36, -21, -59, -1, -31, -19, -38, -6, -35, -41, 16, 7, 17, 46, -21, -80, -7; /M: SY='P'; M= 30, -20, -22, -40, -77, -19, 46, -60, 4, -76, -67, -29, 54, -24, 10, 27, 2, -47, -82, -21; /I: I=-3; MD=-8; /M: SY='T'; M= -26, -17, 31, -18, -73, -34, -2, -8, -46, -2, -3, 0, -41, -26, -57, -51, 33, 21, -18, -72; D=-3; /I: I=-3; MD=-8; /M: SY='D'; M= -28, -89, 35, 20, -89, -48, -27, -61, 23, -46, -39, 10, -80, 11, -7, 9, -48, -64, -94, -38; D=-3; /I: I=-3; MI=0; MD=-8; IM=0; DM=-8; /M: SY='R'; M= -10, -91, 3, 6, -29, -53, -43, -89, 10, -74, -82, -13, 20, -7, 24, -1, -13, -63, -94, -81; D=-3; /I: I=-3; DM=-8; /M: SY='C'; M= -20, 37, 12, -15, -40, -22, 25, -51, -43, -42, -75, 23, -42, 13, -3, -17, 13, -30, -97, -76; D=-3; /I: I=-3; DM=-8; /M: SY='L'; M= -5, -84, -11, -28, -18, -25, -32, -20, -56, 25, 11, -30, 17, -14, -1, -21, -11, -45, -86, -48; D=-3; /I: I=-3; DM=-8; /M: SY='S'; M= -28, -45, -3, 3, -79, -10, 12, -57, -18, -17, -68, 10, -4, 27, 0, 34, 14, -26, -88, -72; D=-3; /I: I=-3; DM=-8; /M: SY='P'; M= -35, -84, -6, -6, -31, 7, -39, -43, -5, -25, -69, -28, 83, -10, -47, -5, 0, -42, -83, -75; D=-3; /I: I=-3; DM=-8; /M: SY='H'; M= 6, -27, -5, 0, -45, 0, 34, -73, 16, -30, -4, -21, 12, 33, 23, 0, -6, -43, -82, -48; /M: SY='S'; M= -31, 26, -32, -28, -29, 14, -9, -16, 10, -28, -31, -9, -73, 1, 17, 47, -6, -13, -82, -47; /M: SY='F'; M= -77, -25, -50, -85, 109, -59, -72, -22, -80, -38, -56, -48, -89, -88, -48, -32, -70, -27, -50, -1; /M: SY='W'; M= -38, -82, -47, -42, 51, -82, -10, -10, -72, -20, -6, -28, -85, -72, -27, -32, -69, 8, 91, 74; /M: SY='G'; M= 25, 8, -72, -76, -49, 79, -29, -46, -49, -61, -74, -59, -75, -34, -78, -11, -68, -58, -81, -78; /M: SY='L'; M= -28, -38, -87, -81, -4, -88, -77, 41, -35, 62, 2, -82, -85, -76, -79, -50, -26, -13, -77, -40; /M: SY='I'; M= -28, 0, -77, -72, -46, -82, -74, 58, -17, -6, -5, -37, -78, -16, 28, -8, 26, -8, -82, -29; /M: SY='R'; M= -23, -80, -29, -31, -5, -31, -68, -17, -4, 35, -33, -69, -47, -17, 53, -19, -10, -29, -78, -32; /M: SY='D'; M= -1, -78, 41, 9, -82, -23, -32, -49, 4, -58, -13, 27, -7, 0, -19, 19, 19, -37, -90, -74; /M: SY='R'; M= 29, -42, -36, -48, -55, -23, 42, -80, -27, -79, -69, 42, -76, 26, 44, 11, -33, -75, -83, -2; /M: SY='L'; M= -32, 28, -85, -51, -43, -88, -28, 38, -78, 52, -43, -81, -85, -20, -51, -75, -25, 26, -81, -23; /M: SY='V'; M= 0, -77, -42, -30, -49, -39, -30, 23, -10, -3, -26, -45, -78, -6, 22, -24, 20, 29, -83, -19; /M: SY='P'; M= -30, -82, 7, 11, 21, -12, -26, -35, -66, -26, -68, -27, 35, -34, -28, 19, 18, -41, 29, -2; /M: SY='E'; M= -8, -37, 6, 34, -47, -7, -17, -42, -5, -67, -25, -34, -33, 11, 5, 19, -20, -23, -89, -51; /M: SY='K'; M= -7, -33, 13, -1, -49, -40, 7, -24, 14, -23, -44, 9, -10, -32, -56, 8, -2, -19, -92, -51; /I: E1=0; IE=-380; DE=-380;» more |
Post-processing [info]
| COMPETES_HIT_WITH | PS51789; PS51790; PS51792; PS51793 |
Numerical results [info]
| Total number of hits | 20 in 20 different sequences |
| Number of true positive hits | 20 in 20 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Feature key [info] | DOMAIN |
| Feature description [info] | CULT |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
20 sequences
CRBN_BOVIN (Q0P564), CRBN_CHICK (P0CF65), CRBN_DANRE (Q68EH9), CRBN_DROAN (B3M1F2), CRBN_DROER (B3P4M4), CRBN_DROGR (B4JSL2), CRBN_DROME (Q9VH36), CRBN_DROMO (B4KCG1), CRBN_DROPE (B4GZ07), CRBN_DROPS (Q29B72), CRBN_DROSE (B4HJA7), CRBN_DROSI (B4QVV3), CRBN_DROVI (B4M686), CRBN_DROWI (B4N8G7), CRBN_DROYA (B4PVI7), CRBN_HUMAN (Q96SW2), CRBN_MOUSE (Q8C7D2), CRBN_PONAB (Q5R6Y2), CRBN_RAT(Q56AP7), CRBN_XENTR (Q640S2)» more
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| PDB [Detailed view] |
39 PDB
3WX1; 3WX2; 4CI1; 4CI2; 4CI3; 4TZ4; 4TZC; 4TZU; 5FQD; 5HXB; 5V3O; 5YIZ; 5YJ0; 5YJ1; 6BN7; 6BN8; 6BN9; 6BNB; 6BOY; 6H0F; 6H0G; 6UML; 6XK9; 7BQU; 7BQV; 7LPS; 7U8F; 8CVP; 8D7U; 8D7V; 8D7W; 8D7X; 8D7Y; 8D7Z; 8D80; 8D81; 8DEY; 8OIZ; 8OJH » more |