Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS. To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017. From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...] View this page in https
Avian leukemia virus E26 is a replication defective retrovirus that induces a
mixed erythroid/myeloid leukemia in chickens. E26 virus carries two distinct
oncogenes, v-myb and v-ets. The ets portion of this oncogene is required for
the induction of erythroblastosis. V-ets and c-ets-1, its cellular progenitor,
have been shown  to be nuclear DNA-binding proteins. Ets-1 differs slightly
from v-ets at its carboxy-terminal region. In most species where it has been
sequenced, c-ets-1 exists in various isoforms generated by alternative
splicing and differential phosphorylation.
A number of proteins, that share regions of similarity with v-ets/c-ets-1,
have been found and are listed below:
Ets-2, which has been sequenced in mammals, chicken, Xenopus and
Human ELF-1, a transcription factor that appears to be required for the T-
cell-receptor-mediated trans activation of HIV-2 genes.
Mammalian ELK-1, ELK-3 (also known as Net or SAP-2) and ELK-4 (also known
as SRF accessory protein 1 (SAP-1)), which all form a ternary complex with
the serum response factor (SRF).
Human ERF, a potent transcriptional repressor that binds to the HI element
of the Ets-2 promoter.
Mammalian ETV1, a transcriptional activator.
FLI-1, a sequence specific transcriptional activator.
Adenovirus E1A enhancer-binding protein (E1A-F) (ETV4) (PEA3).
PU.1 (also known as Spi-1), a protein that binds to a purine-rich sequence,
the PU-box, that can act as a lymphoid-specific enhancer. PU.1 is probably
a transcriptional activator that may be specifically involved in the
differentiation or activation of macrophages or B cells. In mouse, Spi-1 is
an oncogene involved in murine acute friend erythroleukemia.
Spi-B, a transcription factor that binds the PU-box.
GA binding protein (GAPB) α subunit. GAPB is a transcription factor
capable of interacting with purine-rich repeats (GA repeats).
Drosophila protein elg-1.
Drosophila protein pokkuri (pok) (also known as yan), which is a negative
regulator of photoreceptor development.
Drosophila protein pointed (pnt) which is required for glial-neuronal cell
Drosophila ecdysone induced protein 74E.
All these proteins contain a conserved domain, the 'ETS-domain', [2,3,4,5]
involved in DNA-binding. It seems to recognize purine-rich sequences .
This domain, of about 85 to 90 amino acids, is rich in aromatic and positively
charged residues. It is generally localized at the C-terminus of the protein,
with the exception of ELF-1, ELK-1, ELK-3, ELK-4 and ERF where it is found at
We have derived two signature patterns for the ETS-domain. The first one is
based on a highly conserved region in the N-terminal part of the domain, while
the second is based on a region in the second third of the domain. The profile
spans the complete domain.
April 2006 / Pattern revised.
PROSITE methods (with tools and information) covered by this documentation:
Reddy E.S.P., Rao V.N.
Localization and modulation of the DNA-binding activity of the human c-ets-1 protooncogene.
PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
or see: prosite_license.html.