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A subgroup of serine/threonine protein kinases (see <PDOC00100>) playing
multiple role during cell cycle, especially in M phase progression and
cytokinesis, contain a duplicated domain in their C-terminal part, the POLO
box . It is named after its founding member encoded by the polo gene of
Drosophila . This domain of around 70 amino acids has been found in species
ranging from yeast to mammals.
Point mutations in the POLO box of the budding yeast CDC5 protein abolish the
ability of overexpressed CDC5 to interact with the spindle poles and to
organize cytokinetic structures .
Some of the proteins that contain a POLO box are listed below:
Mammalian serine/threonine-protein kinase SNK. May play a role in the
division of cell types, such as fibroblasts and could function in
Mammmalian serine/threonine-protein kinase PLK. PLK is required for cell
division with a role during G1 or S phase.
Drosophila protein kinase Polo. May play a role in regulating both nuclear
and cytoplasmic aspects of the mitotic cycle.
Fission yeast serine/threonine-protein kinase PLO1. Required to form a
bipolar spindle, the actin ring and septum.
Yeast cell cycle protein kinase CDC5/MSD2. Protein kinase required for cell
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Polo-like kinases: positive regulators of cell division from start to finish.
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