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annotation rule: PRU00191

General rule information [?]

Accession PRU00191
Dates 12-DEC-2003 (Created)
16-DEC-2016 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS50001; SH2
Name SH2 domain
Function SH2 domains function as regulatory modules of intracellular signalling cascades by interacting with high affinity to phosphotyrosine- containing target peptides in a sequence-specific and strictly phosphorylation-dependent manner.

Propagated annotation [?]

Keywords [?]

Features [?]

From: PS50001
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       SH2 #        

Additional information [?]

Size range 65-129 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example Q13239 (SLAP1_HUMAN)
Scope Eukaryota
Viruses; Retroviridae


PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to or see: prosite_license.html.

UniProtKB rule member sequences [?]