PROSITE

Accession	PRU00408
Dates	3-MAR-2005 (Created) 27-FEB-2009 (Last updated, Version 11)

Data class

Domain

Predictors

PROSITE; PS50879; RNASE_H

Names

Ribonuclease H domain

Function

Ribonuclease H (RNase H) (EC 3.1.26.4) recognizes and cleaves the RNA strand of RNA-DNA heteroduplexes.

+ RecName: EC=3.1.26.4;

CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-phosphomonoester.

SIMILARITY: Contains 1 RNase H domain.

GO:0004519; Molecular function: endonuclease activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0004518; Molecular function: nuclease activity.

GO:0000287; Molecular function: magnesium ion binding.

Endonuclease, Hydrolase, Nuclease.

Magnesium, Metal-binding.

From: PS50879
Key		From		To		Description		Condition		FTGroup
DOMAIN		from		to		RNase H

Key		From		To		Description		Condition		FTGroup
METAL		10		10		Magnesium (By similarity)		D		1
METAL		50		50		Magnesium (By similarity)		E		1
METAL		74		74		Magnesium (By similarity)		D		1
METAL		127		127		Magnesium (By similarity)		D		1

Size range:	101-205 amino acids
Related UniRules:	None
Repeats:	1
Topology:	Undefined
Example:	Q08885 (RNH_BUCAP)
Scope:	Eukaryota Bacteria Archaea Viruses

PROSITE is copyright. It is produced by the Swiss Institute of Bioinformatics (SIB). There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: http://www.expasy.org/prosite/prosite_license.htm