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annotation rule: PRU00457

General rule information [?]

Accession PRU00457
Dates 29-JUN-2005 (Created)
7-JAN-2017 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS50994; INTEGRASE
Name Integrase catalytic domain
Function The integrase catalytic domain catalyzes a series of reactions to integrate the viral genome into a host chromosome.

Propagated annotation [?]

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0004518; Molecular function: nuclease activity.
GO:0004519; Molecular function: endonuclease activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0006310; Molecular function: DNA recombination.
GO:0006313; Molecular function: transposition, DNA-mediated.
end case

Features [?]

From: PS50994
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Integrase catalytic #        
METAL     12     12       Magnesium; catalytic     D   1
METAL     71     71       Magnesium; catalytic     D   1

Additional information [?]

Size range 43-217 amino acids
Related rules None
Repeats 1
Topology Undefined
Example O92956 (POL_RSVSB)
Scope Eukaryota


PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to or see: prosite_license.html.

UniProtKB rule member sequences [?]