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annotation rule: PRU00500

General rule information [?]

Accession PRU00500
Dates 21-NOV-2005 (Created)
16-DEC-2016 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51162; THYROGLOBULIN_1_2
Names thyroglobulin type-1 domain; Tg type-I repeat
Function the Tg type-1 repeat is a module of about 70 amino acids present 11x in thyroglobulin (Tg) and as a single or repeated sequence in cysteine proteinase inhibitors and other proteins.

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
end case

Features [?]

From: PS51162
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     entry     exit       Thyroglobulin type-1 #        
DISULFID     4     23           disulf   C-x*-C  
DISULFID     34     41           disulf   C-x*-C  
DISULFID     43     63           disulf   C-x*-C  

Additional information [?]

Size range 40-210 amino acids
Related rules None
Repeats 1-11
Topology Undefined
Example P24592 (IBP6_HUMAN)
Scope Eukaryota; Metazoa


PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to or see: prosite_license.html.

UniProtKB rule member sequences [?]