PROSITE

Accession	PRU00683
Dates	17-JAN-2008 (Created) 27-FEB-2009 (Last updated, Version 3)

Data class

Domain

Predictors

PROSITE; PS51349; FMN_HYDROXY_ACID_DH_2

Names

FMN-dependent alpha-hydroxy acid dehydrogenase domain

Function

These enzymes are oxidoreductases that act on alpha-hydroxy acids and which are FMN-containing flavoproteins with a TIM barrel structure.

+ RecName: EC=1.-.-.-;

COFACTOR: FMN (By similarity).

SIMILARITY: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

SIMILARITY: Contains # FMN hydroxy acid dehydrogenase domain.

PROSITE

PS00557; FMN_HYDROXY_ACID_DH_1; 1;

GO:0016491; Molecular function: oxidoreductase activity.

Flavoprotein, FMN.

Oxidoreductase.

From: PS51349
Key		From		To		Description		Condition		FTGroup
DOMAIN		from		to		FMN hydroxy acid dehydrogenase #
NP_BIND		309		333		FMN (By similarity)
ACT_SITE		278		278		Proton acceptor (By similarity)		H
BINDING		27		27		Substrate (Potential)		Y
BINDING		109		109		FMN (By similarity)		S
BINDING		131		131		FMN (By similarity)		Q
BINDING		133		133		Substrate (By similarity)		Y
BINDING		159		159		FMN (By similarity)		T
BINDING		168		168		Substrate (By similarity)		R
BINDING		254		254		FMN (By similarity)		K
BINDING		281		281		Substrate (Potential)		R

Size range:	340-390 amino acids
Related UniRules:	None
Repeats:	1
Topology:	Undefined
Example:	Q6FFS1 (LLDD_ACIAD)
Scope:	Eukaryota Bacteria

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