ProRule PRU00736
General rule information
[?]
| Accession | PRU00736 |
| Dates | 10-DEC-2008 (Created)
21-NOV-2019 (Last updated, Version 10) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51403; NC1_IV |
Name | Collagen IV carboxyl-terminal non-collagenous (NC1) domain |
| Function | Each type IV chain contains a long triple-helical collagenous domain flanked by a short 7S domain of 25 residues and a globular non-collagenous NC1 domain of ~230 residues at the N- and C-terminus, respectively. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | P02462 (CO4A1_HUMAN); |
Propagated annotation
[?]
Comments
[?]
| SUBCELLULAR LOCATION | Secreted, extracellular space, extracellular matrix, basement membrane. |
| DOMAIN | Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain. |
| PTM | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. |
| PTM | Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. |
| SIMILARITY | Belongs to the type IV collagen family. |
Keywords
[?]
| Basement membrane | |
| Collagen | |
| Extracellular matrix | |
| Secreted | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
[?]
| GO:0005604; Cellular component:basement membrane |
| GO:0031012; Cellular component:extracellular matrix |
Features
[?]
| From: PS51403 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Collagen IV NC1 #" | |||||||||
| DISULFID | 16 | 106 | disulf | C-x*-C | ||||||||
| DISULFID | 49 | 103 | disulf | C-x*-C | ||||||||
| DISULFID | 61 | 67 | disulf | C-x*-C | ||||||||
| DISULFID | 125 | 220 | disulf | C-x*-C | ||||||||
| DISULFID | 159 | 217 | disulf | C-x*-C | ||||||||
| DISULFID | 171 | 177 | disulf | C-x*-C | ||||||||
Additional information
[?]
| Size range | 220-230 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Eukaryota [20] All [ 20 ]
- Retrieve set of proteins with 3D structure for this domain