PROSITE logo

ProRule PRU00763


General rule information [?]

Accession PRU00763
Dates 2-MAR-2009 (Created)
13-FEB-2023 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS51432; AP_NUCLEASE_F2_4
Name AP endonucleases family 2
Function Endonuclease 4 related enzymes play a role in DNA repair. These nucleases cleave phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues.
Scope(s) Bacteria
Archaea
Eukaryota
Viruses
Example(s) A4IR02 (END4_GEOTN); Q966U0 (END4_DICDI); Q5UPY4 (END4_MIMIV); Q10002 (APN1_CAEEL);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Bacteria> or <OC:Archaea> or <OC:Amoebozoa>
Protein name AltName: Full=Probable endonuclease 4;
                 EC=3.1.21.2;
AltName: Full=Endonuclease IV;
AltName: Full=Endodeoxyribonuclease IV;
else case <OC:Fungi> or <OC:Nematoda> or <OC:Viruses>

Comments [?]

case <OC:Bacteria> or <OC:Archaea> or <OC:Amoebozoa>
CATALYTIC ACTIVITY Reaction=Endonucleolytic cleavage to 5'-phosphooligonucleotide end- products.; EC=3.1.21.2;
end case

Keywords [?]

DNA damage
DNA repair
Hydrolase
Endonuclease
Nuclease
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
Metal-binding
Zinc
end case
case <OC:Eukaryota>
Nucleus
end case

Gene Ontology [?]

GO:0006974; Biological process:DNA damage response
GO:0006281; Biological process:DNA repair
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding
GO:0003677; Molecular function:DNA binding
case <OCellular component:Bacteria> or <OC:Archaea> or <OC:Amoebozoa> or <OC:Viruses>
GO:0008833; Molecular function:deoxyribonuclease IV (phage-T4-induced) activity
GO:0004519; Molecular function:endonuclease activity
GO:0004518; Molecular function:nuclease activity
GO:0016787; Molecular function:hydrolase activity
else case <OCellular component:Fungi> or <OC:Nematoda>
GO:0003906; Molecular function:DNA-(apurinic or apyrimidinic site) endonuclease activity
end case
case <OCellular component:Eukaryota>
GO:0005634; Cellular component:nucleus
else case <OCellular component:Bacteria> or <OC:Archaea>
GO:0005737; Cellular component:cytoplasm
end case

Cross-references [?]

PROSITE PS00729; AP_NUCLEASE_F2_1; 1;
PROSITE PS00730; AP_NUCLEASE_F2_2; 1;
PROSITE PS00731; AP_NUCLEASE_F2_3; 1;

Features [?]

From: PS51432
Key From To Description Tag Condition FTGroup
BINDING 67 67 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"		 H 1
BINDING 107 107 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"		 H 1
BINDING 143 143 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"		 E 1
BINDING 143 143 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"		 E 2
BINDING 177 177 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"		 D 2
BINDING 180 180 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="3"		 H 3
BINDING 214 214 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"		 H 2
BINDING 227 227 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="3"		 D 3
BINDING 229 229 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="3"		 H 3
BINDING 259 259 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"		 E 2

Additional information [?]

Size range 240-305 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



View rule in raw text format (no links)

UniProtKB rule member sequences [?]