To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
annotation rule: PRU01066

General rule information [?]

Accession PRU01066
Dates 24-SEP-2014 (Created)
19-DEC-2016 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS50968; BIOTINYL_LIPOYL
Name Biotinyl/lipoyl domain
Function Biotin and lipoic acid moieties are the covalently bound cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions. They are attached to a lysine residue, via an amide bond, by specific biotinyl and lipoyl protein ligases.

Propagated annotation [?]


Comments [?]

case <Feature:PS50968:41-42=M-K> or <Feature:PS50968:42-43=K-M>
Cofactor biotin
Note: Biotin.
else case <Feature:PS50968:42=K>
Cofactor (R)-lipoate
Note: Binds 1 lipoyl cofactor covalently.
end case


Keywords [?]

case <Feature:PS50968:41-42=M-K> or <Feature:PS50968:42-43=K-M>
else case <Feature:PS50968:42=K>
end case


Features [?]

case <Feature:PS50968:41-42=M-K> or <Feature:PS50968:42-43=K-M>
From: PS50968
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Biotinyl-binding #        
MOD_RES     42     42       N6-biotinyllysine     K  
else
DOMAIN     from     to       Lipoyl-binding #        
MOD_RES     42     42       N6-lipoyllysine     K  
end case


Additional information [?]

Size range 57-96 amino acids
Related rules None
Repeats 1-3
Topology Undefined
Examples P0A6T9 (GCSH_ECOLI); P0ABD8 (BCCP_ECOLI): [Recover all]
Scope Bacteria
Eukaryota
Archaea
Comments None

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]