annotation rule: PRU01085

General rule information [?]

Accession PRU01085
Dates 11-MAR-2015 (Created)
16-DEC-2016 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51749; HNH_CAS9
Name Cas9-type HNH domain
Function All known Cas9 enzymes contain an HNH domain that cleaves the DNA strand complementary to the guide RNA sequence (target strand).

Propagated annotation [?]


Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0003723; Molecular function: RNA binding.
GO:0004519; Molecular function: endonuclease activity.

Keywords [?]


Features [?]

From: PS51749
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       HNH Cas9-type #        

Additional information [?]

Size range 139-182 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q03JI6 (CAS9B_STRTD)
Scope Bacteria
Comments None

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]