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ProRule PRU01172


General rule information [?]

Accession PRU01172
Dates 1-FEB-2017 (Created)
19-NOV-2022 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51828; PTX_2
Name Pentraxin (PTX) domain
Function Pentraxins (earlier also termed pentaxins), named for their homopentameric quaternary structure, are a superfamily of multifunctional conserved proteins that are characterized by a cyclic multimeric structure and by the presence in their carboxyl-terminal of an ~200 aa-long conserved domain, called pentraxin (PTX) domain.
Scope(s) Eukaryota
Metazoa
Example(s) Q6QNK2 (AGRD1_HUMAN);

Propagated annotation [?]

Keywords [?]

case <FTGroup:1> or <FTGroup:2>
Calcium
Metal-binding
end case
case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE PS00289; PTX_1; 1;

Features [?]

From: PS51828
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Pentraxin (PTX) #"
BINDING 54 54 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"
D 1
BINDING 55 55 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"
N 1
BINDING 133 133 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"
E 1
BINDING 133 133 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"
E 2
BINDING 134 134 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"
Q 1
BINDING 135 135 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"
D 1
BINDING 135 135 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"
D 2
BINDING 145 145 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"
Q 2
DISULFID 32 91 disulf C-x*-C

Additional information [?]

Size range 12-222 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]