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ProRule PRU10094


General rule information [?]

Accession PRU10094
Dates 16-OCT-2006 (Created)
22-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS00141; ASP_PROTEASE
Name Eukaryotic and viral aspartyl proteases active site
Function Undefined
Scope(s) Eukaryota
Viruses
Example(s) P56817 (BACE1_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=Pepsin A;
                 EC=3.4.23.1;

Comments [?]

CATALYTIC ACTIVITY Reaction=Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His- 5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu- 17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.; EC=3.4.23.1;

Features [?]

From: PS00141
Key From To Description Tag Condition FTGroup
ACT_SITE 4 4

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]