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annotation rule: PRU10115

General rule information [?]

Accession PRU10115
Dates 16-OCT-2006 (Created)
26-AUG-2015 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS01062; HMG_COA_LYASE
Name Hydroxymethylglutaryl-coenzyme A lyase active site
Function Undefined.

Propagated annotation [?]

Description [?]

AltName: Full=Hydroxymethylglutaryl-CoA lyase; EC=;

Comments [?]

Catalytic activity (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.

Features [?]

From: PS01062
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     8     8                

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example P35914 (HMGCL_HUMAN)
Scope Eukaryota


PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to or see: prosite_license.html.

UniProtKB rule member sequences [?]