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PROSITE documentation PDOC00784PTR2 family proton/oligopeptide symporters signatures
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00784
A family of eukaryotic and prokaryotic proteins that seem to be mainly involved in the intake of small peptides with the concomitant uptake of a proton has been recently characterized [1,2]. Proteins that belong to this family are:
- Fungal peptide transporter PTR2.
- Mammalian intestine proton-dependent oligopeptide transporter PeptT1.
- Mammalian kidney proton-dependent oligopeptide transporter PeptT2.
- Drosophila opt1.
- Arabidopsis thaliana peptide transporters PTR2-A and PTR2-B (also known as the histidine transporting protein NTR1).
- Arabidopsis thaliana proton-dependent nitrate/chlorate transporter CHL1.
- Lactococcus proton-dependent di- and tri-peptide transporter dtpT.
- Caenorhabditis elegans hypothetical protein C06G8.2.
- Caenorhabditis elegans hypothetical protein F56F4.5.
- Caenorhabditis elegans hypothetical protein K04E7.2.
- Escherichia coli hypothetical protein ybgH.
- Escherichia coli hypothetical protein ydgR.
- Escherichia coli hypothetical protein yhiP.
- Escherichia coli hypothetical protein yjdL.
- Bacillus subtilis hypothetical protein yclF.
These integral membrane proteins are predicted to comprise twelve transmembrane regions. As signature patterns, we selected two of the best conserved regions. The first is a region that includes the end of the second transmembrane region, a cytoplasmic loop as well as the third transmembrane region. The second pattern corresponds to the core of the fifth transmembrane region.
Expert(s) to contact by email: Last update:November 1997 / Patterns and text revised.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Paulsen I.T. Skurray R.A. |
| Title | The POT family of transport proteins. | |
| Source | Trends Biochem. Sci. 19:404-404(1994). | |
| PubMed ID | 7817396 |
| 2 | Authors | Steiner H.-Y. Naider F. Becker J.M. |
| Title | The PTR family: a new group of peptide transporters. | |
| Source | Mol. Microbiol. 16:825-834(1995). | |
| PubMed ID | 7476181 |
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