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PROSITE documentation PDOC00818Protein secE/sec61-gamma signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00818
In bacteria, the secE protein plays a role in protein export; it is one of the components - with secY (see <PDOC00612>) and secA - of the preprotein translocase. In eukaryotes, the evolutionary related protein sec61-γ plays a role in protein translocation through the endoplasmic reticulum; it is part of a trimeric complex that also consist of sec61-α and β [1]. Both secE and sec61-γ are small proteins of about 60 to 90 amino acids that contain a single transmembrane region at their C-terminal extremity (Escherichia coli secE is an exception, in that it possess an extra N-terminal segment of 60 residues that contains two additional transmembrane domains).
The sequence of secE/sec61-γ is not extremely well conserved, however it is possible to derive a signature pattern centered on a conserved proline located 10 residues before the beginning of the transmembrane domain.
Last update:April 2006 / Pattern revised.
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| 1 | Authors | Hartmann E. Sommer T. Prehn S. Goerlich D. Jentsch S. Rapoport T.A. |
| Title | Evolutionary conservation of components of the protein translocation complex. | |
| Source | Nature 367:654-657(1994). | |
| PubMed ID | 8107851 | |
| DOI | 10.1038/367654a0 |
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