PROSITE documentation PDOC00826
Acetate and butyrate kinases family signatures


The following enzymes have been shown [1,2] to be evolutionary related:

  • Acetate kinase (EC (acetokinase) (gene ackA) from bacteria and archaebacteria. This enzyme is involved in the interconversion of acetate and acetyl-CoA via the acetyl phosphate intermediate. In anaerobic growth it provides ATP by catabolyzing acetate phosphate into acetate.
  • Butyrate kinase (EC (gene buk). This enzyme is involved in the interconversion of butyrate and butyryl-CoA via the butyryl phosphate intermediate. Butyrate kinase is involved in the acidogenic phase of fermentation.
  • Propionate kinase (EC 2.7.2,.) (gene tdcD) from Escherichia coli.

We have developed two signature patterns for these enzymes; the first one is located in the N-terminal section and the second in the central section. Both of them are glycine-rich and could be involved in substrate or ATP-binding.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

ACETATE_KINASE_1, PS01075; Acetate and butyrate kinases family signature 1  (PATTERN)

ACETATE_KINASE_2, PS01076; Acetate and butyrate kinases family signature 2  (PATTERN)


1AuthorsGrundy F.J. Waters D.A. Allen S.H.G. Henkin T.M.
TitleRegulation of the Bacillus subtilis acetate kinase gene by CcpA.
SourceJ. Bacteriol. 175:7348-7355(1993).
PubMed ID8226682

2AuthorsOultram J.D. Burr I.D. Elmore M.J. Minton N.P.
TitleCloning and sequence analysis of the genes encoding phosphotransbutyrylase and butyrate kinase from Clostridium acetobutylicum NCIMB 8052.
SourceGene 131:107-112(1993).
PubMed ID8396545

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