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| PROSITE documentation PDOC00826 |
Acetate and butyrate kinases family signatures
Description
The following enzymes have been shown [1,2] to be evolutionary related:
- Acetate kinase (EC 2.7.2.1) (acetokinase) (gene ackA) from bacteria and archaebacteria. This enzyme is involved in the interconversion of acetate and acetyl-CoA via the acetyl phosphate intermediate. In anaerobic growth it provides ATP by catabolyzing acetate phosphate into acetate.
- Butyrate kinase (EC 2.7.2.7) (gene buk). This enzyme is involved in the interconversion of butyrate and butyryl-CoA via the butyryl phosphate intermediate. Butyrate kinase is involved in the acidogenic phase of fermentation.
- Propionate kinase (EC 2.7.2,.) (gene tdcD) from Escherichia coli.
We have developed two signature patterns for these enzymes; the first one is located in the N-terminal section and the second in the central section. Both of them are glycine-rich and could be involved in substrate or ATP-binding.
Last update:December 2004 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Grundy F.J. Waters D.A. Allen S.H.G. Henkin T.M. |
| Title | Regulation of the Bacillus subtilis acetate kinase gene by CcpA. | |
| Source | J. Bacteriol. 175:7348-7355(1993). | |
| PubMed ID | 8226682 |
| 2 | Authors | Oultram J.D. Burr I.D. Elmore M.J. Minton N.P. |
| Title | Cloning and sequence analysis of the genes encoding phosphotransbutyrylase and butyrate kinase from Clostridium acetobutylicum NCIMB 8052. | |
| Source | Gene 131:107-112(1993). | |
| PubMed ID | 8396545 |
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