We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00826Acetate and butyrate kinases family signatures
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00826
Description
The following enzymes have been shown [1,2] to be evolutionary related:
- Acetate kinase (EC 2.7.2.1) (acetokinase) (gene ackA) from bacteria and archaebacteria. This enzyme is involved in the interconversion of acetate and acetyl-CoA via the acetyl phosphate intermediate. In anaerobic growth it provides ATP by catabolyzing acetate phosphate into acetate.
- Butyrate kinase (EC 2.7.2.7) (gene buk). This enzyme is involved in the interconversion of butyrate and butyryl-CoA via the butyryl phosphate intermediate. Butyrate kinase is involved in the acidogenic phase of fermentation.
- Propionate kinase (EC 2.7.2,.) (gene tdcD) from Escherichia coli.
We have developed two signature patterns for these enzymes; the first one is located in the N-terminal section and the second in the central section. Both of them are glycine-rich and could be involved in substrate or ATP-binding.
Last update:December 2004 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Grundy F.J. Waters D.A. Allen S.H.G. Henkin T.M. |
| Title | Regulation of the Bacillus subtilis acetate kinase gene by CcpA. | |
| Source | J. Bacteriol. 175:7348-7355(1993). | |
| PubMed ID | 8226682 |
| 2 | Authors | Oultram J.D. Burr I.D. Elmore M.J. Minton N.P. |
| Title | Cloning and sequence analysis of the genes encoding phosphotransbutyrylase and butyrate kinase from Clostridium acetobutylicum NCIMB 8052. | |
| Source | Gene 131:107-112(1993). | |
| PubMed ID | 8396545 |
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