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PROSITE documentation PDOC00972T-box domain signatures and profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00972
A number of eukaryotic DNA-binding proteins contain a domain of about 170 to 190 amino acids known as the T-box domain [1,2,3] and which probably binds DNA. The T-box has first been found in the mice T locus (Brachyury) protein, a transcription factor involved in mesoderm differentiation. It has since been found in the following proteins:
- Vertebrate and invertebrate homologs of the T protein.
- Mammalian proteins TBX1 to TBX20.
- Mammalian protein TBR1 which is expressed specifically in brain.
- Mammalian and Xenopus laevis eomesodermin (eomes or TBR2).
- Xenopus laevis Vegt (or Antipodean), a transcription factor that activates the expression of wnt-8, eomes and Brachyury.
- Chicken TbxT.
- Drosophila protein optomotor-blind (omb).
- Drosophila protein brachyenteron (byn) (also known as Trg), which is required for the specification of the hindgut and anal pads.
- Drosophila protein H15.
- Caenorhabditis elegans proteins tbx-1 to tbx-40.
As signature patterns for the T-domain, we selected two conserved regions. The first region corresponds to the N-terminal of the domain and the second one to the central part. A profile that spans the complete domain was also developed.
Last update:December 2004 / Patterns and text revised.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Bollag R.J. Siegfried Z. Cebra-Thomas J.A. Garvey N. Davison E.M. Silver L.M. |
| Title | An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. | |
| Source | Nat. Genet. 7:383-389(1994). | |
| PubMed ID | 7920656 | |
| DOI | 10.1038/ng0794-383 |
| 2 | Authors | Agulnik S.I. Garvey N. Hancock S. Ruvinsky I. Chapman D.L. Agulnik I. Bollag R. Papaioannou V. Silver L.M. |
| Title | Evolution of mouse T-box genes by tandem duplication and cluster dispersion. | |
| Source | Genetics 144:249-254(1996). | |
| PubMed ID | 8878690 |
| 3 | Authors | Papaioannou V.E. |
| Title | T-box family reunion. | |
| Source | Trends Genet. 13:212-213(1997). | |
| PubMed ID | 9196325 |
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