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PROSITE documentation PDOC00972 |
A number of eukaryotic DNA-binding proteins contain a domain of about 170 to 190 amino acids known as the T-box domain [1,2,3] and which probably binds DNA. The T-box has first been found in the mice T locus (Brachyury) protein, a transcription factor involved in mesoderm differentiation. It has since been found in the following proteins:
As signature patterns for the T-domain, we selected two conserved regions. The first region corresponds to the N-terminal of the domain and the second one to the central part. A profile that spans the complete domain was also developed.
Last update:December 2004 / Patterns and text revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Bollag R.J. Siegfried Z. Cebra-Thomas J.A. Garvey N. Davison E.M. Silver L.M. |
Title | An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. | |
Source | Nat. Genet. 7:383-389(1994). | |
PubMed ID | 7920656 | |
DOI | 10.1038/ng0794-383 |
2 | Authors | Agulnik S.I. Garvey N. Hancock S. Ruvinsky I. Chapman D.L. Agulnik I. Bollag R. Papaioannou V. Silver L.M. |
Title | Evolution of mouse T-box genes by tandem duplication and cluster dispersion. | |
Source | Genetics 144:249-254(1996). | |
PubMed ID | 8878690 |
3 | Authors | Papaioannou V.E. |
Title | T-box family reunion. | |
Source | Trends Genet. 13:212-213(1997). | |
PubMed ID | 9196325 |