PROSITE documentation PDOC51017CCT domain profile
The CCT (CONSTANS, CO-like, and TOC1) domain is a highly conserved basic module of ~43 amino acids, which is found near the C-terminus of plant proteins often involved in light signal transduction. The CCT domain is found in association with other domains, such as the B-box zinc finger (see <PDOC50119>), the GATA-type zinc finger (see <PDOC00300>), the ZIM motif or the response regulatory domain (see <PDOC50110>). The CCT domain has been shown to be involved in nuclear localization and probably also has a role in protein-protein interaction [1,2].
Some proteins known to contain a CCT domain are listed below:
- Plant CONSTANS family of transcription factors.
- Plant GATA factor subfamily III [3].
- Arabidopsis thaliana timing of CAB expression 1 (TOC1) or ABI3-interacting protein 1 (AIP1).
- Arabidopsis thaliana TOC1-Like (TL).
The profile we developed covers the entire CCT domain.
Last update:September 2004 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Strayer C. Oyama T. Schultz T.F. Raman R. Somers D.E. Mas P. Panda S. Kreps J.A. Kay S.A. |
| Title | Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog. | |
| Source | Science 289:768-771(2000). | |
| PubMed ID | 10926537 |
| 2 | Authors | Robson F. Costa M.M.R. Hepworth S.R. Vizir I. Pineiro M. Reeves P.H. Putterill J. Coupland G. |
| Title | Functional importance of conserved domains in the flowering-time gene CONSTANS demonstrated by analysis of mutant alleles and transgenic plants. | |
| Source | Plant J. 28:619-631(2001). | |
| PubMed ID | 11851908 |
| 3 | Authors | Reyes J.C. Muro-Pastor M.I. Florencio F.J. |
| Title | The GATA family of transcription factors in Arabidopsis and rice. | |
| Source | Plant Physiol. 134:1718-1732(2004). | |
| PubMed ID | 15084732 | |
| DOI | 10.1104/pp.103.037788 |
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