PROSITE documentation PDOC51017
CCT domain profile


The CCT (CONSTANS, CO-like, and TOC1) domain is a highly conserved basic module of ~43 amino acids, which is found near the C-terminus of plant proteins often involved in light signal transduction. The CCT domain is found in association with other domains, such as the B-box zinc finger (see <PDOC50119>), the GATA-type zinc finger (see <PDOC00300>), the ZIM motif or the response regulatory domain (see <PDOC50110>). The CCT domain has been shown to be involved in nuclear localization and probably also has a role in protein-protein interaction [1,2].

Some proteins known to contain a CCT domain are listed below:

  • Plant CONSTANS family of transcription factors.
  • Plant GATA factor subfamily III [3].
  • Arabidopsis thaliana timing of CAB expression 1 (TOC1) or ABI3-interacting protein 1 (AIP1).
  • Arabidopsis thaliana TOC1-Like (TL).

The profile we developed covers the entire CCT domain.

Last update:

September 2004 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CCT, PS51017; CCT domain profile  (MATRIX)


1AuthorsStrayer C. Oyama T. Schultz T.F. Raman R. Somers D.E. Mas P. Panda S. Kreps J.A. Kay S.A.
TitleCloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog.
SourceScience 289:768-771(2000).
PubMed ID10926537

2AuthorsRobson F. Costa M.M.R. Hepworth S.R. Vizir I. Pineiro M. Reeves P.H. Putterill J. Coupland G.
TitleFunctional importance of conserved domains in the flowering-time gene CONSTANS demonstrated by analysis of mutant alleles and transgenic plants.
SourcePlant J. 28:619-631(2001).
PubMed ID11851908

3AuthorsReyes J.C. Muro-Pastor M.I. Florencio F.J.
TitleThe GATA family of transcription factors in Arabidopsis and rice.
SourcePlant Physiol. 134:1718-1732(2004).
PubMed ID15084732

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