PROSITE documentation PDOC51019Reelin domain profile
The reelin domain is a ~170 amino acid module, which has been identified in the amino terminus of the extracellular matrix proteins reelin and F-spondin (renamed Spon1). The spondin domain is found in association with other modules, such as the thrombospondin type I repeat (TSP1) (see <PDOC50092>), the spondin domain (see <PDOC51020>), the fibronectin type III domain (see <PDOC50853>) or the Kunitz trypsin protease inhibitor domain (see <PDOC00252>). The function of the reelin domain is not yet known [1,2,3].
The profile we developed covers the entire reelin domain.
Last update:September 2004 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | D'Arcangelo G. Miao G.G. Chen S.-C. Soares H.D. Morgan J.I. Curran T. |
| Source | Nature 374:719-723(1995). |
| 2 | Authors | Higashijima S. Nose A. Eguchi G. Hotta Y. Okamoto H. |
| Title | Mindin/F-spondin family: novel ECM proteins expressed in the zebrafish embryonic axis. | |
| Source | Dev. Biol. 192:211-227(1997). | |
| PubMed ID | 9441663 |
| 3 | Authors | Feinstein Y. Borrell V. Garcia C. Burstyn-Cohen T. Tzarfaty V. Frumkin A. Nose A. Okamoto H. Higashijima S. Soriano E. Klar A. |
| Title | F-spondin and mindin: two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons. | |
| Source | Development 126:3637-3648(1999). | |
| PubMed ID | 10409509 |
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