PROSITE documentation PDOC51019
Reelin domain profile


The reelin domain is a ~170 amino acid module, which has been identified in the amino terminus of the extracellular matrix proteins reelin and F-spondin (renamed Spon1). The spondin domain is found in association with other modules, such as the thrombospondin type I repeat (TSP1) (see <PDOC50092>), the spondin domain (see <PDOC51020>), the fibronectin type III domain (see <PDOC50853>) or the Kunitz trypsin protease inhibitor domain (see <PDOC00252>). The function of the reelin domain is not yet known [1,2,3].

The profile we developed covers the entire reelin domain.

Last update:

September 2004 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

REELIN, PS51019; Reelin domain profile  (MATRIX)


1AuthorsD'Arcangelo G. Miao G.G. Chen S.-C. Soares H.D. Morgan J.I. Curran T.
SourceNature 374:719-723(1995).

2AuthorsHigashijima S. Nose A. Eguchi G. Hotta Y. Okamoto H.
TitleMindin/F-spondin family: novel ECM proteins expressed in the zebrafish embryonic axis.
SourceDev. Biol. 192:211-227(1997).
PubMed ID9441663

3AuthorsFeinstein Y. Borrell V. Garcia C. Burstyn-Cohen T. Tzarfaty V. Frumkin A. Nose A. Okamoto H. Higashijima S. Soriano E. Klar A.
TitleF-spondin and mindin: two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons.
SourceDevelopment 126:3637-3648(1999).
PubMed ID10409509

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